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  • 1
    Electronic Resource
    Electronic Resource
    Recurrent angiosarcoma effectively treated with superselective continuous intra-arterial injection of recombinant interleukin-2 combined with radiotherapy (1998)
    Springer
    International journal of clinical oncology 3 (1998), S. 396-399 
    Details
    ISSN: 1437-7772
    Keywords: Angiosarcoma ; Interleukin-2 ; Intra-arterial injection ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of recurrent angiosarcoma (AS) in a 63-year-old man, effectively treated with a superselective continuous intra-arterial injection of recombinant interleukin-2 (rIL-2) combined with electron beam radiotherapy. The patient, who had undergone surgical resection for AS on his face near the nasal bridge, was admitted to our hospital because of recurrent AS on his bilateral cheeks. We placed 4-French catheters in the right external carotid artery (ECA) and superselectively in the left facial artery. A continuous intra-arterial injection of rIL-2 was administered in combination with radiotherapy using a 6 MeV electron beam. The lesion rapidly decreased in size. The total dose of rIL-2 was 3.72 × 107 IU (International Unit) in the right ECA and 2.96 × 107 IU in the left facial artery, while the total radiation dose was 50 Gy, in 25 fractions, for the tumor on the right cheek and 46 Gy, in 23 fractions, for the erythematous plaque on the left cheek. The patient was discharged with almost no cutaneous lesion on his cheeks. Unfortunately, there was another recurrence of AS and the patient died of respiratory failure due to lung metastases. However, as the lesion could be completely controlled even for a while, we believe this treatment method will contribute to the future management of AS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539220
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Glucose entry into rat mesangial cells is mediated by both Na+-coupled and facilitative transporters (1995)
    Springer
    Diabetologia 38 (1995), S. 291-297 
    Details
    ISSN: 1432-0428
    Keywords: Key words Na+-coupled glucose transporter ; facilitative glucose transporters ; mesangial cells ; glomerulopathy ; phlorizin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since previous studies from our laboratory have demonstrated that increased glucose consumption by cultured rat mesangial cells is accompanied by an accelerated production of type IV and type VI collagen, we have now examined the manner by which glucose is transported into these cells. A progressive stimulation of glucose uptake by the mesangial cells was observed with increasing concentrations of NaCl so that at 145 mmol/l about twice as much glucose entered the cells as in its absence (substituted by choline chloride). Moreover, since phlorizin inhibited the NaCl-promoted uptake of glucose and this salt was found to increase the accumulation of α-methylglucoside in a manner which could not be duplicated by KCl or mannitol, both Na+-coupled and facilitative glucose transporters appeared to be present in the cells. Km values of 1.93 mmol/l and 1.36 mmol/l were determined for the co-transport and facilitated transport pathways, respectively, with their Vmax being 29.5 and 18.0 nmol · mg protein− 1· h− 1. Both uptake activities were found to be down-regulated by exposure of the cells to high glucose and furthermore the Na+-dependent transport could no longer be detected after about 12 passages of the cells. Hybridization of mesangial cell mRNA with cDNA probes revealed transcripts for the Na+/glucose co-transporter as well as GLUT1 and to a lesser extent GLUT4. The identification of the co-transporter in these non-polarized cells is pertinent to an understanding of the intracellular signals which can lead to the development of the diabetic glomerular lesions; in the hyperglycaemic state this carrier provides an additional route for accelerated glucose entry and furthermore by the attendant increase in Na+ flux may bring about an alteration in the ionic composition of the cell. [Diabetologia (1995) 38: 291–297]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400633
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Glucose entry into rat mesangial cells is mediated by both Na+-coupled and facilitative transporters (1995)
    Springer
    Diabetologia 38 (1995), S. 291-297 
    Details
    ISSN: 1432-0428
    Keywords: Na+-coupled glucose transporter ; facilitative glucose transporters ; mesangial cells ; glomerulopathy ; phlorizin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since previous studies from our laboratory have demonstrated that increased glucose consumption by cultured rat mesangial cells is accompanied by an accelerated production of type IV and type VI collagen, we have now examined the manner by which glucose is transported into these cells. A progressive stimulation of glucose uptake by the mesangial cells was observed with increasing concentrations of NaCl so that at 145 mmol/l about twice as much glucose entered the cells as in its absence (substituted by choline chloride). Moreover, since phlorizin inhibited the NaCl-promoted uptake of glucose and this salt was found to increase the accumulation of α-methylglucoside in a manner which could not be duplicated by KCl or mannitol, both Na+-coupled and facilitative glucose transporters appeared to be present in the cells. Km values of 1.93 mmol/l and 1.36 mmol/l were determined for the co-transport and facilitated transport pathways, respectively, with their Vmax being 29.5 and 18.0 nmol·mg protein−1· h−1. Both uptake activities were found to be down-regulated by exposure of the cells to high glucose and furthermore the Na+-dependent transport could no longer be detected after about 12 passages of the cells. Hybridization of mesangial cell mRNA with cDNA probes revealed transcripts for the Na+/glucose co-transporter as well as GLUT1 and to a lesser extent GLUT4. The identification of the co-transporter in these non-polarized cells is pertinent to an understanding of the intracellular signals which can lead to the development of the diabetic glomerular lesions; in the hyperglycaemic state this carrier provides an additional route for accelerated glucose entry and furthermore by the attendant increase in Na+ flux may bring about an alteration in the ionic composition of the cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400633
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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