ISSN:
1573-6903
Keywords:
Ischemia
;
ulinstatin-like substance
;
μ-calpain
;
m-calpain
;
murine hippocampus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Effects of ischemia on the content of a ulinastatin (UT)-like substance in the murine cerebral cortex and hippocampus were studied. At 24 h post-ischemia, a significant (p 〈 0.05) decrease in the content of UT-like substance in the hippocampus but not the cerebral cortex and a concurrent increase in the activity of μ-calpain were observed. In in vitro experiments, a decrease was registered in the content of UT-like substance in the hippocampus in the presence of calcium. This decrease was inhibited by both EDTA and calpastatin treatments. These results implicate the destruction of UT-like substance by μ-calpain in the ischemic hippocampus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1022453504527
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