ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. Using two murine strains, ICR/Jcl and senescence-accelerated-prone inbred mouse 1 (SAMP1), age-associated changes in urine indices (e.g. urine volume, creatinine contents, contents of α1-microglobulin (α1M) and ulinastatin (UT)) and the relation of urinary contents of α1M and UT were investigated.2. Sex-related differences in the indices were not observed in ICR nor in SAMP1 mice.3. Urine indices per 24 h of ICR mice at 6 and 14 months of age were higher than those at 3 months of age, although indices of SAMP1 mice did not change with ageing. Urinary contents of α1M and UT in ICR mice at 6 and 14 months of age were higher than those in SAMP1 mice. However, contents of α1M and UT expressed as the contents per creatinine did not differ between these two strains.4. In the relation between urinary contents of α1M and UT, a positive correlation was displayed both in ICR and SAMP1 mice, and the regression slope did not significantly differ with ageing in these two strains.5. These results suggest that ageing per se is not a factor which affects the relation of urinary contents of α1M and UT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1440-1681.1999.03093.x
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