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Digitale Medien

Specific cleavage of chicken αA-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I (1991)

Bronstein, I. B. ; Gromova, I. I. ; Razin, S. V.

Springer

Molecular and cellular biochemistry 101 (1991), S. 115-124

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Details

ISSN: 1573-4919

Schlagwort(e): DNA topoisomerase I ; camptothecin ; αA-globin gene ; c-Ha-ras gene

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie , Medizin

Notizen: Summary Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken αA-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00229529

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Digitale Medien

DNA interactions with the nuclear matrix and spatial organization of replication and transcription (1987)

Razin, S. V.

New York, NY : Wiley-Blackwell

BioEssays 6 (1987), S. 19-23

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Details

ISSN: 0265-9247

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Analysis of the DNA sequence associated with the nuclear matrix has made it possible to identify several types of DNA matrix association. Permanent attachment sites are detected in both transcriptionally active and inactive nuclei. Furthermore, replication origins have been shown to be permanently attached to the nuclear matrix. In transcriptionally active nuclei, expressed genes are also associated with the nuclear matrix. Finally, a special group of attachment sites is described; these sites are believed to maintain the fixed positions of individual chromosomes in interphase nuclei.

Zusätzliches Material: 2 Ill.