ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The Transamination of aromatic amino acids in brain is of interest due to its involvement in the biosynthesis of catechol and indole amines. Previous reports have established the presence of aromatic amino acid transaminases in brain (Canellakis and Cohen, 1962; Albers, Koval and Jakoby. 1962; Haavaldsen, 1962).It was subsequently reported that rat brain extracts contain at least three aromatic amino acid transaminases (Transaminase-I, II and III) (Fosnum, Haavaldsen and Tangen, 1964; Tangen, Fowum and Haavaldsen, 1965: Fohwum and Larsen, 1965): Transaminase-I had a high affinity for DOPA, Transaminase-II an affinity for phenylalanine and tyrosine, and Transaminase-III an affinity for tryptophan and 5-HTP. The preferred aminoacceptor of these enzymes was 2-oxoglutarate or oxaloacetate.The present paper describes the aromatic amino acid transaminases in an extract of rat brain, which differ from the three transaminases described by Tangenet al. (1965).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1973.tb00261.x
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