ISSN:
1432-1041
Keywords:
aminophylline
;
bronchodilatation
;
lung function
;
plasma concentrations
;
theophylline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Twelve patients with partly reversible, chronic airway obstruction, according to a double blind randomized cross-over design, received on three consecutive days oral aminophylline 500 mg, a 500 mg aminophylline suppository and a placebo. The effects on ventilatory function were studied and the plasma concentration of theophylline was measured. After rectal administration, the plasma concentration of theophylline rose to 5 to 10 µg/ml, and after oral ingestion the plasma level in most patients exceeded 10 µg/ml. Administration of the aminophylline suppository resulted in moderate improvement in ventilatory function, and although the improvement was less pronounced than after oral administration, the use of a suppository in the treatment of patients with chronic obstructive lung disease should not be rejected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561738
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