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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 1007-1012 
    ISSN: 1432-1440
    Keywords: Hyperparathyroidism ; Immunoreactive parathyroid hormone ; Selectively catheterized thyroid veins ; Hyperparathyreoidismus ; Immunreaktives Parathormon ; Selektiv sondierte Schilddrüsenvenen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 16 Patienten mit primärem oder sekundärem Hyperparathyreoidismus wurden selektiv Blutproben aus den Hals- und Schilddrüsenvenen gewonnen. Das immunreaktive Parathormon wurde mit zwei aminoterminal-(Anti-N)- und drei caboxylterminal-(Anti-C)-spezifischen Antiseren gemessen. Zwei Anti-C Seren und ein Anti-N-Serum erwiesen sich als geeignet zur Lokalisation der Nebenschilddrüsentumoren. Zusätzlich wurden die Parathormonfragmente durch Gelfiltration aufgetrennt, die Immunreaktivität in den Eluaten wurde mit Anti-N-und Anti-C-Seren bestimmt. Die Ergebnisse ließen erkennen, daß die Eignung der Antiseren zur Lokalisationsuntersuchung durch ihre Affinität für intaktes Hormon bestimmt wird, unabhängig von ihrer Anti-N-oder Anti-C-Eigenschaft.
    Notes: Summary Blood samples were obtained from 16 patients with primary or secondary hyperparathyroidism by selectively catheterising cervical and thyroid veins. Immunoreactive parathyroid hormone was measured with two aminoterminal (anti-N)- and three carboxyl-terminal (anti-C)-specific antisera. Two anti-C sera and one anti-N serum were useful in localising the parathyroid tumors. In addition, the parathyroid hormone fragments were separated by gelfiltration and the immunoreactivity in the effluent was estimated with anti-N and anti-C sera. The results suggest that the usefulness of antisera for parathyroid tissue localisation is determined by their affinity for the intact hormone, regardless of their anti-N or anti-C qualities.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1432-2277
    Keywords: Conversion from steroids to azathioprine, in kidney transplantation ; Azathioprine conversion after steroids, in kidney transplantation ; Acute rejection after conversion, in kidney transplantation ; Cyclosporin and conversion, in kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In renal graft recipients primarily treated with cyclosporin and low-dose methylprednisolone, withdrawal of the long-term steroid medication increases the likelihood of developing rejection episodes. In order to determine the predictive value of clinical parameters and routine prewithdrawal graft biopsies for the risk of rejection, the authors studied 141 kidney recipients from whom steroids were with-drawn 7–9 months after transplantation in a clinically stable situation. Both the quality of the HLA-match and the results of prospective graft biopsies were found to correlate significantly to the occurrence of acute rejection. In order to investigate the influence of additional azathioprine medication on the incidence of acute rejections in recipients not receiving steroids, immunosuppression was continued with cyclosporin monotherapy in 88 patients and with cyclosporin plus azathioprine in 53 patients. The risk of developing rejection episodes was significantly reduced from 48% after 1 year on monotherapy to 28% after the addition of azathioprine medication.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 15 (1983), S. 281-288 
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The important role of immunological factors, HLA typing and pretransplant blood transfusion on improved kidney graft survival is well established. Additionally, graft survival depends on risk factors such as diabetes and age of the recipient. The effect of other clinical risk factors on graft survival was evaluated in 187 patients who received kidney transplants at our centre between 1970 and 1981. Graft survival according to the life table method and statistical analysis according to the logrank test revealed 4 main risk factors. Graft survival is significantly lower in type I diabetics and analgesic nephropathy, whereas it is better in hereditary and other renal diseases. Additional risk factors are coronary heart disease and repeated grafting. Time of dialysis before transplantation and age of the recipient showed no detrimental effect on graft survival.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 297 (1977), S. 75-80 
    ISSN: 1432-1912
    Keywords: Vitamin D resistancy ; 5,6-trans-25-hydroxycholecalciferol ; Renal osteodystrophy ; Hypoparathyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relative vitamin D resistance in patients with chronic renal failure and in those with hypoparathyroidism is due to an impairment of 1-hydroxylation of cholecalciferol. 5,6-trans-25OHCC, which has a similar steric configuration as 1,25(OH)2CC was examined at a daily dose of 18,000 IU for 14 days in both diseases. Intestinal 47calcium absorption as well as serum calcium level could be normalized in most patients with hypoparathyroidism. The improvement was less in patients with chronic renal failure, suggesting an additional depressing influence of uremia on calcium metabolism.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 29-33 
    ISSN: 1432-1912
    Keywords: Solanum Malacoxylon ; Line Test ; Vitamin D ; Rickets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The plant Solanum malacoxylon (S.M.) is known to cause severe soft tissue calcifications in cattle and sheep and has recently become of special, interest since it exerts biological actions which resemble those of vitamin D. In order to investigate whether S.M. is capable to improve the rachitic bone changes in vitamin d and phosphate deficient rats, a watery extract of 50, 100 and 200 mg S.M. was fed daily to these animals over a period of 10 days. The width of epiphyseal plates was compared after that time with those of rats treated with 0, 0.225, 0.45 and 0.9 IU of vitamin D3 daily. There was a dose related curative effect of S.M. on the epiphyseal lesions very similar to that of vitamin D3. The hypercalcemic and hyperphosphatemic effect of S.M. was identical to that of vitamin D3. The 25-hydroxy-vitamin D serum levels remained almost undetectable, in the S.M. treated rats as well as in the vitamin D3 treated animals.
    Type of Medium: Electronic Resource
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