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  • Electronic Resource  (18)
  • 1
    Electronic Resource
    Electronic Resource
    Additions and Corrections - Basic Antiinflammatory Compounds. N,N'N''-Trisubstituted Guanidines. (1980)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 23 (1980), S. 1459-1459 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00186a601
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  • 2
    Electronic Resource
    Electronic Resource
    Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines (1980)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 23 (1980), S. 13-20 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00175a004
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunological Effects of d-Penicillamine during Experimentally Induced Inflammation in Rats (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Administration of d-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells. Treatment with d-penicillamine abolished the ability of macrophages from arthritic rats to inhibit lymphocyte responsiveness to Con A and lipopolysaccharide (LPS) 14 days after the induction of the disease. Increased T-cell responsiveness to Con A was found from day 14 to day 35 in cultures of unseparated and adherent-cell-depleted lymph node cells from d-penicillamine-treated arthritic rats. B-cell responsiveness to LPS was not affected. Experiments with bovine serum albumin gradient-separated lymph node cells confirmed these findings and indicated that treatment with d-penicillamine may specifically enhance T-helper cell responsiveness to Con A. It is suggested that administration of d-penicillamine may interfere with macrophage function during the course of an immunologically induced chronic inflammation, leading to an increased response of T-helper cells. The theoretical implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00064.x
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  • 4
    Electronic Resource
    Electronic Resource
    d-Penicillamine in Vivo Enhances Lymphocyte DN A Synthesis: Role of Macrophages (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 11 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Administration of d-penicillamine (50 mg/kg/day orally) for 4 days increased the uptake of 3H-thymidine (3H-TdR) in unstimulated and concanavalin -A-stimulated unseparated lymph node and spleen cells from Lewis rats. Increased 3H-TdR incorporation was also found in cultures depleted of adherent cells. d-Penicillamine treatment did not increase the incorporation of 3H-TdR in lymph node and spleen cells from rats concomitantly treated with the selective macro-phage toxin silica. in contrast, treatment with d-penicillamine during the last 4 days of silica treatment sometimes resulted in a marked decrease in 3H-TdR incorporation. It is suggested that d-penicillamine treatment in vivo is able to enhance the responsiveness of the lymphocytes, dependent on the presence of functionally intact macrophages. The increased response vanished after 2-3 weeks, even with continuous administration of d-penicillamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00204.x
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  • 5
    Electronic Resource
    Electronic Resource
    D-Penicillamine and Macrophages: Modulation of Lymphocyte Transformation by Concanavalin A (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 7 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pretreatment with d-Penicillamine of rat peritoneal macrophages markedly influences their ability to modulate Concanavalin A stimulated [3H]thymidine incorporation in non-adherent rat lymph node cells. Untreated macrophages added in high numbers to the lymphocytes (ratio lymphocytes/macrophage 7.5:1) depress their [3H]thymidine incorporation. Pretreatment with d-Penicillamine further reduces this response. Lower proportions of untreated macrophages (ratio 15:1) exert a stimulatory effect on the lymphocytes. This response is reversed by pretreatment of macrophages with d-Penicillamine. Addition of untreated macrophages in very low proportions (40:1 and 75:1) is without effect on the [3H]thymidine incorporation by the lymphocytes. This response is markedly stimulated by pretreatment of the macrophages with d-Penicillamine. The culture of macrophages in the presence of D-Penicillamine increases their incorporation of [3H]d-glucosamine, but it is without effect on their incorporation of [3H]l-leucine. It is suggested that d-Penicillamine enhances the functional activity of the macrophage in the regulation of the lymphocyte response to mitogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb00453.x
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  • 6
    Electronic Resource
    Electronic Resource
    Captopril (SQ 14,225): In vitro and in vivo influence on the proliferative response of rat lymphocytes (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 399-401 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Captopril in vitro (50–500 μg/ml) increased3H-TdR incorporation in unstimulated and mitogen-stimulated cultures of rat lymphocytes. Unseparated spleen and lymph node cells of rats orally treated with captopril (50 mg/kg/day×4) showed decreased basal and mitogen stimulated3H-TdR incorporation. The removal of macrophages abrogated this inhibitory effect. Leucine aminopeptidase activity of macrophages was reduced — in vivo and in vitro — by captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01949416
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  • 7
    Electronic Resource
    Electronic Resource
    Inhibition of adjuvant arthritis by intraperitoneal administration of low doses of silica (1980)
    Springer
    Inflammation research 10 (1980), S. 435-438 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Daily intraperitoneal administration from day 3 to day 10 post-adjuvant of crystalline silica in doses 1.5–3.1 mg/kg per day or of amorphous silica in doses of 12.5 mg/kg per day inhibited the development of adjuvant arthritis mostly suppressing the swelling of the non-injected paw. These doses of silica did not impair the carbon elearance. Higher doses of silica (25 mg/kg per day of the crystalline form and 50 mg/kg of the amorphous form) administered from day 17 to day 24 post-adjuvant had no effect on the already established disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968043
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  • 8
    Electronic Resource
    Electronic Resource
    Chronic inflammation in adjuvant arthritic rats correlates with enhancement of 12-l-HETE-synthesis (1981)
    Springer
    Inflammation research 11 (1981), S. 587-589 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of chronic inflammation in adjuvant arthritic rats was found to be strongly correlated with the appearance in serum of a factor (HSF) which enhanced the formation of 12-l-HETE by platelet-lipoxygenase, and with the serum-concentration of 12-l-HETE. The latter was determined by scanning at 235 nm after extraction and high performance thin-layer chromatography. Arthritic rat platelet-rich plasma (PRP) converted exogenous arachidonic acid to 12-l-HETE at a rate 2.6-fold higher than control rat PRP. By resuspending arthritic rat platelets in normal rat plasma, and normal rat platelets in arthritic rat plasma, this increase in conversion rate was found to be caused by HSF present in the arthritic rat plasma. Treatment of arthritis with non-steroidal anti-inflammatory drugs inhibited HSF activity as well as the increase in serum-12-l-HETE concentration, which indicates a prostaglandin-mediated mechanism of HSF synthesis or release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01978753
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  • 9
    Electronic Resource
    Electronic Resource
    Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1230-1232 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Peritoneal macrophages from rats with adjuvant arthritis enhance the incorporation of3H-thymidine in 2 tumour cell lines in vitro. Maximal enhancement is found during the development of the secondary lesions, and it is suggested that the immunologic commitment of the macrophages could interfere with their regulation of tumour cell proliferation in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963307
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  • 10
    Electronic Resource
    Electronic Resource
    Investigations on the influence of Cyclophosphamide, gold sodium thiomalate andd-penicillamine on nystatin oedema and adjuvant arthritis (1975)
    Springer
    Inflammation research 5 (1975), S. 264-267 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclophosphamide (5 or 10 mg/kg p.o.) and Gold sodium thiomalate (0 or 40 mg/kg i.m.) inhibit after repeated administrations (5 days) all the phases of Nystatin edema, whereas a single administration is ineffective.d-Penicillamine (25 or 100 mg/kg p.o.) inhibits the early phases of Nystatin edema after a single administration whereas repeated administrations are almost ineffective. An early treatment with Cyclophosphamide (2.5 mg/kg p.o.) simply delays the appearance of the secondary lesions of adjuvant arthritis but inhibit the development of the primary lesions. A late treatment with Cyclophosphamide as well as both the types of treatment with Gold sodium thiomalate (10 mg/kg i.m.) are effective against primary and secondary lesions. The only effect ofd-Penicillamine (50 mg/kg p.o.) in adjuvant arthritis is a significant incaease of the intensity of secondary lesions during the late treatment. It is suggested that the anti-inflammatory activity of Cyclophosphamide does not depend exclusively upon its effective on some cell population committed in the inflammatory reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026441
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