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  • 1
    Electronic Resource
    Electronic Resource
    Market processes and thwarting systems
    Amsterdam : Elsevier
    Structural Change and Economic Dynamics 3 (1992), S. 79-91 
    Details
    ISSN: 0954-349X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0954-349X(92)90027-4
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  • 2
    Electronic Resource
    Electronic Resource
    Technical change and wage-share fluctuations in a regime-switching model
    Amsterdam : Elsevier
    Journal of Economic Behavior and Organization 19 (1992), S. 369-377 
    Details
    ISSN: 0167-2681
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-2681(92)90043-B
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  • 3
    Electronic Resource
    Electronic Resource
    A wage-price regime switching model
    Amsterdam : Elsevier
    Journal of Economic Behavior and Organization 13 (1990), S. 77-95 
    Details
    ISSN: 0167-2681
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-2681(90)90054-H
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in opiate activity of rat pituitary following acute administration of neuroleptics (1980)
    Springer
    Psychopharmacology 69 (1980), S. 59-62 
    Details
    ISSN: 1432-2072
    Keywords: Sulpiride ; Trifluoperazine ; Dexamethasone ; Pituitary endorphins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An increase was found in the opiate activity of pituitary extracts obtained from rats injected with the neuroleptic drugs trifluoperazine and sulpiride. The increase of opiate activity, measured by bioassay, was particularly evident 2 h after the administration of sulpiride. Dexamethasone completely prevented the neuroleptic-induced effect. Trifluoperazine and sulpiride may have affected dopaminergic mechanisms regulating endorphin storage in the pituitary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426522
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  • 5
    Electronic Resource
    Electronic Resource
    Liver abnormalities in Turner syndrome (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 618-623 
    Details
    ISSN: 1432-1076
    Keywords: Key words Alanine aminotransferase ; Aspartate aminotransferase ; γ-Glutamyl transferase ; Oestrogens ; Turner syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated whether hepatic abnormalities represent a specific feature in girls with Turner syndrome (TS) or whether they are related to an increased susceptibility to hormonal therapies and/or other factors. Alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transferase were monitored in 70 patients with TS for a mean period of 7.6 ± 4.2 years. An increase in serum liver enzymes was observed in 14 out of 70 girls (20%) at a mean age of 12.7 years; it was present at entry before hormonal therapy in 3 girls and developed thereafter during the follow up in the other 11. The increase in serum liver enzymes was never observed before the age of 7 years. In the majority of cases (10/14) it was drug related: in 50% the liver abnormalities were transient and self-limiting, in the remaining cases they required interruption of hormonal therapy. Hepatotoxicity was more frequently observed in girls treated with oestrogens or oxandrolone than in those treated with growth hormone. In a small number of cases, liver disease was either auto-immunity-related (2/14), or cryptogenic (1/14) with a benign and self-limiting course. Obesity was a frequent finding, but it played a likely pivotal role only in one patient. Conclusion Hepatic abnormalities are relatively frequent in Turner syndrome and surveillance of liver function should be included in the management of these patients independent of initiation of hormonal treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051163
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  • 6
    Electronic Resource
    Electronic Resource
    CLUSTER MISSION OPERATIONS (1997)
    Springer
    Space science reviews 79 (1997), S. 475-485 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The Cluster ground segment design and mission operations concept have been defined according to the basic mission requirements, namely, to allow the transfer of the four spacecraft from the initial geostationary transfer orbit achieved at separation from the launcher into the final highly elliptical polar orbits, such that in the areas of scientific interest along their orbits, the four spacecraft will form a tetrahedral configuration with pre-defined separation distances, to be changed every six months during the mission. The Cluster mission operations will be carried out by ESA from its European Space Operations Centre; the task of merging the Principal Investigators' requests into coordinated, regular scientific mission planning inputs to ESOC will be undertaken by the Joint Science Operations Centre. The mission products will be distributed to the scientific community regularly in form of CD-ROMs. Principal Investigators will also have access to quick-look science, housekeeping telemetry and auxiliary data via an electronic network.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004998320043
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  • 7
    Electronic Resource
    Electronic Resource
    Use of plasma levels for antiepileptic drug monitoring in clinical practice (1992)
    Springer
    Neurological sciences 13 (1992), S. 59-65 
    Details
    ISSN: 1590-3478
    Keywords: Anticonvulsants-blood ; epilepsy-occurrence ; drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In uno studio multicentrico condotto su 245 casi di epilessia di “nuova” diagnosi (trattati da meno di 3 mesi) e su 355 casi di epilessia di “vecchia” diagnosi (trattati da almeno 3 mesi)l'uso dei livelli plasmatici dei farmaci anticonvulsivanti è stato valutato in relazione alle modalità di trattamento e a problemi specifici indicati dai clinici. La percentuale di richieste di livelli plasmatici era del 75% e riguardava il 69% delle visite di follow-up nei pazienti di “nuova” diagnosi. Le percentuali erano rispettivamente del 78% e del 34% per i pazienti di vecchia diagnosi. In entrambi i casi vi era una marcata variabilità tra centri nelle percentuali di prescrizioni. Le richieste di livelli plasmatici erano più numerose nei pazienti in politerapia. Per contro, il monitoraggio dei farmaci antiepilettici non risultava influenzato dalla presenza di specifici problemi, quali il non completo controllo della crisi o la presenza di segni di tossicità farmacologica, né dall'età del paziente o dal tempo intercorso dalla formulazione della diagnosi. Da tutto ciò deriva che l'utilizzo dei livelli plasmatici dei farmaci antiepilettici nella pratica clinica è influenzato da fattori che spesso non riflettono le norme di comportamento comunemente suggerite dalla letteratura. Risultano inoltre ampiamente confermati i limiti delle metodiche attualmente in uso.
    Notes: Abstract A multi-center survey of antepileptic treatment was conducted in Italy on 245 previously untreated (“new”) patients with epilepsy and 355 patients treated for more than three months (“old” patients). Therapeutic drug monitoring (TDM) of antiepileptic drugs was evaluated in the context of routine clinical conditions, in relation to individual therapeutic problems and mode of treatment. Plasma levels (PL) were determined in 75% of “new” patients and 78% of “old” patients, with wide intercenter variability. TDM was done at 69% of the follow-up attendences for “new” patients and at 34% for “old” patients, but was apparently unrelated to specific therapeutic problems, such as poor disease control or adverse drug reactions. Plasma drug concentration measurements were made more often among patients on polytherapy. The age of the patient and the time elapsing since diagnosis did not seem to affect request patterns significantly. From these findings it appears that TDM is largerly influenced by factors unrelated to the common recommendations in the literature. In addition, the use of TDM in clinical practice reflects the limitations of the available techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222890
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  • 8
    Electronic Resource
    Electronic Resource
    Diagnosis of diabetic polyneuropathy Correlation between clinical and instrumental findings and assessment of simple diagnostic criteria (1988)
    Springer
    Neurological sciences 9 (1988), S. 577-582 
    Details
    ISSN: 1590-3478
    Keywords: Polyneuritis ; diabetic neuropathies ; diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Nella presente indagine alcuni criteri clinici ed elettrofisiologici di minima per la diagnosi di polineuropatia diabetica (PD) sono stati scelti e testati su di un campione non selezionato di 48 soggetti afferenti all'Ambulatorio di Diabetologia dell'Ospedale Universitario di Chieti. Su ciascun paziente è stato eseguito un esame strumentale standard a carico dei nervi mediano (sensitivo e motore), peroneo e surale. Con riferimento alla relativa importanza dei parametri strumentali per ciascun nervo, a velocità di conduzione, latenza distale ed ampiezza dei potenziali furono attribuiti punteggi che variavano da 0,5 a 2. Veniva formulata una diagnosi di probabile PD quando il punteggio totale su almeno due nervi era di 2,5 o più. Sul totale, 28 casi (58%) avevano un quadro strumentale a sostegno della diagnosi di probabile PD. Per quanto vi fosse una correlazione relativamente alta tra positività dell'esame clinico e diagnosi di probabile PD, i coefficienti di validità dell'esame neurologico non risultavano sufficientemente elevati da consentirne l'impiego per lo screening della PD.
    Notes: Abstract In the present study minimal clinical and electrophysiological criteria for the diagnosis of diabetic polyneuropathy (DP) have been tested in 48 unselected subjects attending an outpatient service for diabetics at the University Hospital of Chieti. A standard electrophysiological examination was performed in all patients on the median nerve (sensory and motor), peroneal nerve and sural nerve. Depending on the importance of the laboratory values for each nerve, nerve conduction velocity, distal latency and potential amplitude were given separate scores ranging from 0.5 to 2. A diagnosis of probable DP was made when abnormal findings were present in more than one nerve with a total score of 2.5 or more. As a whole, 28 cases (58%) had abnormal laboratory findings supporting the diagnosis of probable DP. There was a relatively high correlation between probable DP and a positive clinical examination although the validity coefficients of the neurological exam were not high enough to allow its use as a screening test for DP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02337012
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