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  • 1995-1999  (16)
  • 1935-1939  (1)
  • 1998  (16)
  • 1939  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Recognition surfaces of MHC class I (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 163 (1998), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Recent crystallographic results have provided dose to atomic resolution views of the recognition events mediated by MHC class I molecules. The specificity-conferring interaction of MHC class I/peptide with a T-cell antigen receptor (TCR) appears dependent on certain key interactions with the MHC scaffold. These interactions, in particular those of the TCR Va domain, define a standard orientation for TCR binding. Previous studies on biologically significant variations in the TCR recognition surface presented by a series of MHC/variant peptide complexes can be reassessed in the light of this TCR-building mode. The interaction of CDS with MHC class I resembles that between antibody and antigen in the use of loops from the CD8 structure. The interaction is of very low affinity and buries equivalent surface area to that between the TCR and MHC class I but while the TCR/MHC interface shows poor surface shape complementarity the match in the conservative interaction between MHC and CDS is precise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1998.tb01191.x
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  • 2
    Electronic Resource
    Electronic Resource
    Camptothecin induces differentiation, tissue transglutaminase and apoptosis in cultured keratinocytes (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 7 (1998), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cultured normal human adult keratinocytes were exposed to (S)-(+)- camptothecin over the concentration range 10-5 to 10-10 M. The dose-dependent inhibition of growth was recorded using cell counting. The induction of terminal differentiation was demonstrated by the relative increase in squamous and cornified cells, and the concomitant decrease in small, proliferative cells, with an overall decrease in total cell numbers on going from 10-10 to 10-6 M concentration of the drug. The induction of apoptosis was studied by assay of two types of transglutaminase, “tissue” and “keratinocyte”, and by assay of histonelinked mono- and oligonucleosomes. Induction of apoptosis was accompanied with increase in “tissue” transglutaminase and in the amount of nucleosomes, the latter being indicative of endonuclease activity. This activity was sharply increased at a camptothecin concentration of 10-5 M, and may have been faciliated by “tissue” transglutaminase at lower concentrations. The data suggest that camptothecin restricts keratinocyte growth by several mechanisms including apoptosis and emphasize its possible use in topical therapy for psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1998.tb00321.x
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  • 3
    Electronic Resource
    Electronic Resource
    Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release (1998)
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 28 (1998), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Analysis of the DNA sequence of a 17 kb region of the coli lambdoid phage H-19B genome located the genes encoding shiga-like toxin I (Stx-I) downstream of the gene encoding the analogue of the phage λ Q transcription activator with its site of action, qut at the associated pR′ late promoter, and upstream of the analogues of λ genes encoding lysis functions. Functional studies, including measurement of the effect of H-19B Q action on levels of Stx expressed from an H-19B prophage, show that the H-19B Q acts as a transcription activator with its associated pR′(qut) by promoting readthrough of transcription terminators. Another toxin-producing phage, 933W, has the identical Q gene and pR′(qut) upstream of the stx-II genes. The H-19B Q also activates Stx-II expression from a 933W prophage. An ORF in H-19B corresponding to the holin lysis genes of other lambdoid phages differs by having only one instead of the usual two closely spaced translation initiation signals that are thought to contribute to the time of lysis. These observations suggest that stx-I expression can be enhanced by transcription from pR′ as well as a model for toxin release through cell lysis mediated by action of phage-encoded lysis functions. Functional studies show that open reading frames (ORFs) and sites in H-19B that resemble components of the N transcription antitermination systems controlling early operons of other lambdoid phages similarly promote antitermination. However, this N-like system differs significantly from those of other lambdoid phages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.1998.00890.x
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  • 4
    Electronic Resource
    Electronic Resource
    A homeobox gene, HLXB9 , is the major locus for dominantly inherited sacral agenesis (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 20 (1998), S. 358-361 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Partial absence of the sacrum is a rare congenital defect which also occurs as an autosomal dominant trait; association with anterior meningocoele, presacral teratoma and anorectal abnormalities constitutes the Currarino triad (MIM 176450). Malformation at the caudal end of the developing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/3828
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  • 5
    Electronic Resource
    Electronic Resource
    Generalized syntheses of large-pore mesoporous metal oxides with semicrystalline frameworks (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 396 (1998), S. 152-155 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Surfactants have been shown to organize silica into a variety of mesoporous forms, through the mediation of electrostatic, hydrogen-bonding, covalent and van der Waals interactions. This approach to mesostructured materials has been extended, with sporadic success, to non-silica oxides, which ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/24132
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  • 6
    Electronic Resource
    Electronic Resource
    The atomic structure of the bluetongue virus core (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 470-478 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The structure of the core particle of bluetongue virus has been determined by X-ray crystallography at a resolution approaching 3.5 Å. This transcriptionally active compartment, 700 Å in diameter, represents the largest molecular structure determined in such detail. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/26694
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  • 7
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2) (1998)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 433-435 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Molecules of the human killer cell inhibitory receptor (KIR) family, which belong to the immunoglobulin superfamily (IgSF), are expressed on the surface of natural killer (NK) cells and some subsets of T cells. These receptors function to mediate the inhibition or activation of cytotoxic activity by recognizing HLA class I molecules on the target cell. The extracellular region of a p58 KIR specific for HLA-Cw1,3,7 (KIR2) has been overproduced in Escherichia coli and purified. The recombinant KIR2 has been crystallized in 9–10% poly(ethylene glycol) methyl ether (average Mr = 8000), 50mM HEPES, 8% ethylene glycol, 0.5% octyl-β-glucoside, pH 7.5, at 294 K using the sitting-drop vapour-diffusion method. Preliminary X-ray diffraction studies reveal the space group to be hexagonal (P6122 or P6522) with lattice constants a = b = 95.3, c = 130.8 Å. A native data set (3 Å resolution) has been collected at the Photon Factory (λ = 1.0 Å).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444997012201
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  • 8
    Electronic Resource
    Electronic Resource
    Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration (1998)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 938-953 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A crystal form of HIV-1 reverse transcriptase (RT) complexed with inhibitors showed diffraction to a high-resolution limit of 3.7 Å. Instability in the unit-cell dimensions of these crystals was observed during soaking experiments, but the range of this variability and consequent change in lattice order was revealed by a chance observation of dehydration. Deliberately induced dehydration results in crystals having a variety of unit cells, the best-ordered of which show diffraction to a minimum Bragg spacing of 2.2 Å. In order to understand the molecular basis for this phenomenon, the initial observation of dehydration, the data sets from dehydrated crystals, the crystal packing and the domain conformation of RT are analysed in detail here. This analysis reveals that the crystals undergo remarkable changes following a variety of possible dehydration pathways: some changes occur gradually whilst others are abrupt and require significant domain rearrangements. Comparison of domain arrangements in different crystal forms gives insight into the flexibility of RT which, in turn, may reflect the internal motions allowing this therapeutically important enzyme to fulfill its biological function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444998004284
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  • 9
    Electronic Resource
    Electronic Resource
    Large unit cells and cellular mechanics (1998)
    [s.l.] : Nature America Inc.
    Nature structural biology 5 (1998), S. 630-634 
    Details
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Developments in synchrotron radiation mean that the methodological and technological tools are in place to determine the structures of large multi-component macromolecular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1322
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  • 10
    Electronic Resource
    Electronic Resource
    The early phase of glucose-stimulated insulin secretion requires nitric oxide (1998)
    Springer
    Diabetologia 41 (1998), S. 292-299 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Nitric oxide ; nitrogen monoxide ; insulin secretion ; glucose ; nitric oxide synthase ; alpha cell ; beta cell ; delta cell.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nitric oxide (nitrogen monoxide, NO) acts as a signal transducer in a variety of cells. In the present study rat pancreatic islets were perifused with physiologically relevant glucose concentrations in the presence or absence of various NO-modulating agents. Perifusion in the presence of 0.1–1 mmol/l of the NO synthase inhibitor, NG-monomethyl-L-arginine or of 10 μmol/l of the NO-scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), resulted in an inhibition of the early phase of glucose-stimulated insulin secretion by 60–65 % and 46 %, respectively. Light- and electron-microscopic studies revealed that pancreatic islets constitutively express NO-synthase in alpha and delta cells, where it is confined to the secretory granules. Therefore, these data indicate that NO may be important in the signal transduction pathway of the early phase of glucose-stimulated insulin secretion. [Diabetologia (1998) 41: 292–299]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050906
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