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  • 2000-2004  (12)
  • 1955-1959  (7)
  • 2002  (12)
  • 1956  (7)
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  • 2000-2004  (12)
  • 1955-1959  (7)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Activation of caspase-3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neurochemistry 80 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activated caspase-3 is considered an important enzyme in the cell death pathway. To study the specific role of caspase-3 activation in neuronal cells, we generated a stable tetracycline-regulated SK-N-MC neuroblastoma cell line, which expressed a highly efficient self-activating chimeric␣caspase-3, consisting of the caspase-1 prodomain fused to the caspase-3 catalytic domain. Under expression-inducing conditions, we observed a time-dependent increase of processed caspase-3 by immunostaining for the active form of the enzyme, intracellular caspase-3 enzyme activity, as well as poly(ADP-ribose) polymerase (PARP) cleavage. Induced expression of the caspase fusion protein showed predominantly caspase-3 activity without any apoptotic morphological changes. In contrast, staurosporine treatment of the same cells resulted in activation of multiple caspases and profound apoptotic morphology. Our work provides evidence that auto-activation of caspase-3 can be efficiently achieved with a longer prodomain and that neuronal cell apoptosis may require another caspase or activation of multiple caspase enzymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0022-3042.2002.00787.x
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  • 2
    Electronic Resource
    Electronic Resource
    Above-room-temperature ferromagnetism in GaSb/Mn digital alloys (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 81 (2002), S. 511-513 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Digital alloys of GaSb/Mn have been fabricated by molecular-beam epitaxy. Transmission electron micrographs showed good crystal quality with individual Mn-containing layers well resolved, no evidence of three-dimensional MnSb precipitates was seen in as-grown samples. All samples studied exhibited ferromagnetism with temperature-dependent hysteresis loops in the magnetization accompanied by metallic p-type conductivity with a strong anomalous Hall effect (AHE) up to 400 K (limited by the experimental setup). The anomalous Hall effect shows hysteresis loops at low temperatures and above room temperature very similar to those seen in the magnetization. The strong AHE with hysteresis indicates that the holes interact with the Mn spins above room temperature. All samples are metallic, which is important for spintronics applications. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1481184
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  • 3
    Electronic Resource
    Electronic Resource
    Business Newsletter... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 383-383 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a001
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Research Newsletter... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 385-385 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a002
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  • 5
    Electronic Resource
    Electronic Resource
    Ag and Food Interprets... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 389-394 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a004
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  • 6
    Electronic Resource
    Electronic Resource
    News of the Month... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 395-399 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a005
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  • 7
    Electronic Resource
    Electronic Resource
    CORN-KING OF CROPS: Whatever influences this No. 1 crop affects virtually every American (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 402-409 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a006
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  • 8
    Electronic Resource
    Electronic Resource
    New Products and Equipment... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 462-463 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a021
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  • 9
    Electronic Resource
    Electronic Resource
    Literature Available... (1956)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 4 (1956), S. 464-464 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00127a022
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  • 10
    Electronic Resource
    Electronic Resource
    IL-18 Production in Human Pulmonary and Pleural Tuberculosis (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-18 (IL-18) has multiple important pro-inflammatory effects, including the induction of interferon-γ (IFN-γ) in various diseases. In this study, we investigated the IL-18-producing activities in human pulmonary and pleural tuberculosis (TB) in response to purified protein derivative (PPD) antigen (Ag) from Mycobacterium tuberculosis. The most significant IL-18 production was found in chronic refractory TB (CRTB) patients. However, IFN-γ production in CRTB patients was significantly less than that in healthy tuberculin reactors or in patients with tuberculous pleurisy (TBP). Elevated levels of both IL-18 and IFN-γ were found in pleural fluids from TBP patients. In vitro production of IL-18 was dramatically decreased following an 18 h stimulation with PPD. However, IFN-γ was markedly increased in pleural mononuclear cells from TBP patients after in vitro stimulation with PPD. The mesothelial cell type was the main source of pro-IL-18 in pleural cells from TBP patients, suggesting an important role for these cells in TBP. Taken together, these data indicate that IL-18 is elevated in peripheral blood mononuclear cells from CRTB patients, as well as at the site of TBP, indicating a possible role for IL-18 in both protective immunity and pathologic responses in human TB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01143.x
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