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  • 1975-1979  (2)
  • 1965-1969  (1)
  • 1975  (2)
  • 1966  (1)
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  • 1975-1979  (2)
  • 1965-1969  (1)
Year
  • 1
    ISSN: 1432-0568
    Keywords: Corticotropin releasing factor ; Neurosecretion ; Hypophysis ; X-irradiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 195 female Wistar rats the influence of adrenalectomy, total body X-irradiation and dexamethasone treatment on the amount of CRF-granules in the external zone of the median eminence and “classical” neurosecretory material (NSM) in the internal zone of the median and in the posterior lobe of the hypophysis has been studied. In the normal rat only very few CRF-granules occur. 15 days after adrenalectomy increased amounts of CRF-granules but normal amounts of “classical” NSM are found. X-irradiation leads to a slight diminishment of “classical” NSM in normal rats. In adrenalectomized animals X-irradiation causes no changes in the amount of “classical” NSM but a marked decrease in the amount of CRF-granules. Application of dexamethasone from the 15th to 18th day after adrenalectomy enhances the augmentation of CRF-granules in irradiated and non-irradiated rats but does not influence the amount of “classical” NSM. The findings show that no correlation exists between the quantitative changes of CRF-granules and “classical” NSM under the experimental conditions used. Therefore it is to be assumed that the release of the two substances is regulated by different control mechanisms and that the substances have a different functional significance. The observations do not exclude the possibility that CRF-granules and “classical” NSM are biochemically identical.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 163 (1975), S. 503-508 
    ISSN: 1432-0878
    Keywords: Infundibulum ; Gomori-positive elementary granules ; Mammals ; Birds ; Fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the gallocyanine technique (Wittkowski, Bock and Franken, 1970) Gomori-positive substances of the infundibulum can be stained for light- and electron-microscopic examination. In various mammalian species, the size of Gomori-positive elementary granules in the outer layer is markedly different from that in the inner layer of the infundibulum. In general, the granules of the outer layer have less then half the diameter of those of the inner layer. In birds and fish, however, only small differences were found between the granules of both layers. The significance of the results is discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Psychometrika 31 (1966), S. 507-534 
    ISSN: 1860-0980
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract A general method is presented for estimating variance components when the experimental design has one random way of classification and a possibly unbalanced fixed classification. The procedure operates on a sample covariance matrix in which the fixed classes play the role of variables and the random classes correspond to observations. Cases are considered which assume (i) homogeneous and (ii) nonhomogeneous error variance, and (iii) arbitrary scale factors in the measurements and homogeneous error variance. The results include maximum-likelihood estimations of the variance components and scale factors, likelihood-ratio tests of the goodness-of-fit of the model assumed for the design, and large-sample variances and covariances of the estimates. Applications to mental test data are presented. In these applications the subjects constitute the random dimension of the design, and a classification of the mental tests according to objective features of format or content constitute the fixed dimensions.
    Type of Medium: Electronic Resource
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