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  • 1975-1979  (2)
  • 1965-1969  (2)
  • 1975  (2)
  • 1968  (2)
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  • 1975-1979  (2)
  • 1965-1969  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Influence of adrenalectomy, total body X-irradiation and dexamethasone on the amount of CRF-Granules and “classical” neurosecretory material in the rat neurohypophysis (1975)
    Springer
    Anatomy and embryology 148 (1975), S. 267-278 
    Details
    ISSN: 1432-0568
    Keywords: Corticotropin releasing factor ; Neurosecretion ; Hypophysis ; X-irradiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 195 female Wistar rats the influence of adrenalectomy, total body X-irradiation and dexamethasone treatment on the amount of CRF-granules in the external zone of the median eminence and “classical” neurosecretory material (NSM) in the internal zone of the median and in the posterior lobe of the hypophysis has been studied. In the normal rat only very few CRF-granules occur. 15 days after adrenalectomy increased amounts of CRF-granules but normal amounts of “classical” NSM are found. X-irradiation leads to a slight diminishment of “classical” NSM in normal rats. In adrenalectomized animals X-irradiation causes no changes in the amount of “classical” NSM but a marked decrease in the amount of CRF-granules. Application of dexamethasone from the 15th to 18th day after adrenalectomy enhances the augmentation of CRF-granules in irradiated and non-irradiated rats but does not influence the amount of “classical” NSM. The findings show that no correlation exists between the quantitative changes of CRF-granules and “classical” NSM under the experimental conditions used. Therefore it is to be assumed that the release of the two substances is regulated by different control mechanisms and that the substances have a different functional significance. The observations do not exclude the possibility that CRF-granules and “classical” NSM are biochemically identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319847
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gomori-positive elementary granules in inner and outer layer of the infundibulum (1975)
    Springer
    Cell & tissue research 163 (1975), S. 503-508 
    Details
    ISSN: 1432-0878
    Keywords: Infundibulum ; Gomori-positive elementary granules ; Mammals ; Birds ; Fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the gallocyanine technique (Wittkowski, Bock and Franken, 1970) Gomori-positive substances of the infundibulum can be stained for light- and electron-microscopic examination. In various mammalian species, the size of Gomori-positive elementary granules in the outer layer is markedly different from that in the inner layer of the infundibulum. In general, the granules of the outer layer have less then half the diameter of those of the inner layer. In birds and fish, however, only small differences were found between the granules of both layers. The significance of the results is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218495
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Beiträge zur funktionellen Morphologie der Neurohypophyse (1968)
    Springer
    Cell & tissue research 92 (1968), S. 130-148 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Am Infundibulum der normalen weißen Maus lassen sich eine „gomoripositive“ Zona interna und eine „gomorinegative“ Zona externa unterscheiden. Nach beidseitiger Adrenalektomie tritt vom 6. Tag post Operationem ab in der Zona externa infundibuli eine „gomoripositive“ Substanz auf, die histochemisch dem Neurosekret des supraoptico-hypophysären Systems ähnelt. Sie findet sich nicht bei einseitig adrenalektomierten oder scheinoperierten Mäusen. Die mögliche Identität der Substanz mit dem Trägerprotein des (eines) Corticotropin-releasing-factors wird diskutiert.
    Notes: Summary In the median eminence of the normal white mouse, a “Gomori-positive” internal layer and a “Gomori-negative” external layer can be distinguished. From the sixth day following bilateral adrenalectomy, a “Gomori-positive” substance appears in the external layer, which shows a histochemical similarity to the neurosecretory substance of the supraoptico-hypophyseal system. This does not occur after unilateral adrenalectomy or sham-operation. The possibility, that this substance is identical with the carrier protein of the (of a) corticotropin releasing-factor, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339407
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Färberische Beobachtungen zur Frage nach dem primären Bildungsort von Neurosekret im supraoptico-hypophysären System (1968)
    Springer
    Cell & tissue research 87 (1968), S. 534-544 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An Embryonen und Jungtieren von Maus und Huhn wurde die Entwicklung des neurosekretorischen hypothalamo-hypophysären Systems untersucht. Dabei gelang es, neurosekretorisches Material in den Perikaryen des Systems zum gleichen Zeitpunkt nachzuweisen, zu dem es in der Neurohypophyse erstmalig auftrat. In vergleichend-anatomischen Untersuchungen an erwachsenen Tieren ließ sich bei einer Reihe von Säugetierarten Neurosekret im Verlauf des gesamten Neurons sichtbar machen. Korrespondierende Neuronabschnitte verschiedener Spezies enthielten dabei vergleichbare Neurosekretmengen. Die Befunde wurden mit verbesserten Verfahren zur färberischen Darstellung von Neurosekret gewonnen. Die von ihnen abweichenden Ergebnisse früherer Untersuchungen beruhen auf unzulänglichen Methoden und können daher nicht gegen die Hypothese eines intraaxonalen Neurosekret-Transportes ins Feld geführt werden.
    Notes: Summary The development of the neurosecretory hypothalamo-hypophyseal system of mouse and chick embryos has been studied. Neurosecretory granules could be identified in the perikarya of the neurosecretory cells simultaneously with their first appearance in the neurohypophysis. Subsequently, a variety of adult mammalian species was investigated. In all cases, neurosecretory material could be demonstrated along the whole length of the neurons. Comparison of corresponding parts of the neurons showed them to contain comparable amounts of neurosecretory material. The investigations were carried out with improved techniques for staining neurosecretory material. Results of earlier investigations, inconsistent with these findings, were obtained with inadequate methods and cannot be regarded as contradicting the hypothesis of an intraaxonal transport of neurosecretory material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00325584
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    Paper (German National Licenses)
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