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  • 1970-1974  (3)
  • 1973  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Binary transition metal dinitrogen complexes. I. Matrix infrared and Raman spectra, structure and bonding of Ni(N2)n and Pd(N2)m(n = 1-4 and m = 1-3) (1973)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 95 (1973), S. 332-344 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00783a007
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The glomerular basement membrane of the rabbit kidney on long-term treatment with heterologous insulin preparations of different purity (1973)
    Springer
    Diabetologia 9 (1973), S. 255-263 
    Details
    ISSN: 1432-0428
    Keywords: Monocomponent insulin ; proinsulin ; insulin-antigenicity ; glomerulus ; glomerular basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 90 rabbits were treated with monocomponent insulin (MC Actrapid Novo) and a+b component (proinsulin, intermediates, “dimer”, high-molecular proteins) and their solvents for 3 months without Freund's adjuvant. The insulin-binding capacity of the serum, as an expression of the antibody titre, as well as the light and electron microscopic structure of the glomerular basement membrane were studied. It was shown that on treatment with MC insulin there was no significant antibody formation and no increased occurrence of subepithelial, hump-like, basement membrane protuberances. In contrast, following immunization with a+b component there was a significantly higher antibody titre and a pronounced increase in nodular basement membrane changes of the glomeruli. The findings show that the impurities (a+b component) in the insulins in normal commercial usage are evidently responsible for the higher antigenicity. Further, it can be demonstrated that investigations of glomerular structures allow one to draw conclusions as to the degree of the antigenicity of different insulin preparations although the actual cause of the increased occurrence of basement membrane changes with increasing antigenicity of the insulin preparation is still unclarified. Possible causes which ought to be discussed are deposition of immune complexes and/or increased and structurally atypical basement membrane synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221851
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chromosomes in patients treated with Azathioprine (1973)
    Springer
    Human genetics 〈Berlin〉 18 (1973), S. 231-236 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Chromosomen aus peripherem Blut und direkten Knochenmarkspräparaten von Patienten unter Azathioprin-Therapie wurden verglichen mit solchen von gesunden Kontrollpersonen und urämischen Patienten ohne Azathioprin-Einnahme. Die Ergebnisse sprechen für eine toxische Chromosomenschädigung sowohl durch Azathioprin als auch die urämische Stoffwechsellage. Die Bedeutung dieser Befunde, insbesondere im Zusammenhang mit mehrfach berichteten malignen Prozessen nach Azathioprin-Einnahme, wird diskutiert. Unsere Ergebnisse lassen eher einen Zusammenhang zwischen Immunosuppression und malignem Geschehen vermuten als eine direkte cancerogen Wirkung von Azathioprin.
    Notes: Summary Chromosomes from leukocyte cultures and direct bone marrow preparations from patients under Azathioprine treatment were examined and compared with those from uremic patients and normal controls not taking Azathioprine. The results indicate a toxic effect of the drug, as well as an effect of uremia on the chromosome complement. The significance of these findings is discussed, especially in relation to several reports concerning malignant processes arising during or after Azathioprine intake. According to our findings, a relation between immunosuppression and malignancy seems more likely than a direct cancerogenicity of Azathioprine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290602
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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