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  • 1970-1974  (6)
  • 1974  (6)
Source
Material
Years
  • 1970-1974  (6)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 153-158 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.
    Notes: Summary The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284500
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The carcinogenic effect of 2-oxo-propyl-propylnitrosamine in Sprague-Dawley rats (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 23-28 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chronische Wirkung von 2-Oxo-propyl-propylnitrosamin (2-OPPN) wurde an Sprague-Dawley Ratten untersucht. Die Tiere zeigten vorwiegend hepatocelluläre Carcinome, die Wirkung dieses Carcinogens war dosisabhängig. Die Ergebnisse wurden unter der Annahme diskutiert, daß 2-OPPN möglicherweise ein Metabolit des Di-n-propylnitrosamins ist.
    Notes: Summary The chronic effect of 2-oxo-propyl-propylnitrosamine (2-OPPN) was examined in Sprague-Dawley rats. The animals showed mainly hepatocellular carcinomata; the effect of the carcinogen was dose dependent. The findings are discussed under the assumption that 2-OPPN might be a metabolite of di-n-propylnitrosamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303597
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of pancreas tumours by di-isopropanolnitrosamine (1974)
    Springer
    Naturwissenschaften 61 (1974), S. 328-328 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00599567
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of intraperitoneal injections of dimethyl- and diethylnitrosamine, alone or simultaneously on Swiss mice (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 233-238 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
    Notes: Summary Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304061
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of nitroso compounds (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 229-233 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten als Einzeldosis subcutan Dimethyl-(DMN) oder Diäthylnitrosamin-(DEN). In statistisch gesicherter Abhängigkeit von der applizierten Carcinogenmenge beider Substanzen (je 5 Gruppen) zeigten sich beim Vergleich mit den Kontrollen jeweils ein Anstieg der Lungentumorhäufigkeit (ausgenommen die niedrigste DMN Dosis). Darüber hinaus fanden sich bei Tieren mit langer Überlebenszeit Sarkome an der Injektionsstelle. Die Ergebnisse lassen den Schluß zu, daß bei Untersuchungen an Mäusen mit minimalen Carcinogendosen neben dem Anstieg der Lungentumorrate auch andere Parameter Bedeutung haben.
    Notes: Summary A single subcutaneous injection of dimethyl-(DMN) or diethylnitrosamine (DEN) was administered to Swiss mice at five dose levels. A statistically significant increase in the incidence of lung tumours was observed at all dose levels for both compounds except for the group receiving the lowest dose of DMN. In addition, subcutaneous sarcomata developed late in life at the site of injection. These findings might indicate that the mouse assay of minimal carcinogenic levels of nitrosamines is pertinent not only for the lung tumour test, but also for other parameters namely those associated with longer survival rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305023
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of Nitroso compounds (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 251-259 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die onkogene Wirkung einer Einzeldosis von N-nitrosopiperidin und N-nitrosomorpholin wurde am Syrischen Goldhamster untersucht. Es fanden sich vorwiegend Neoplasmen im Respirationstrakt, wobei die Trachea besonders betroffen war. Wie ultrastrukturelle Beobachtungen bestätigten, stellten die Trachealtumoren Polypen dar. Zellen der Oberfläche von Tumoren wie auch der darunter liegenden epithelialen Anteile differenzierten sich noch in Flimmerepithelzellen und Schleimzellen. Neben der Tumorentstehung zeigten sich hyperplastische und dysplastische Veränderungen des Trachealepithels.
    Notes: Summary The oncogenic effects of a single dose of N-nitrosopiperidine and N-nitrosomorpholine were examined in Syrian golden hamsters. The main target organ was the respiratory system; the majority of neoplasms was found in the trachea. As ultra-structural investigations could confirm, the tracheal tumours were polyps. Surface lining tumour cells as well as cells in the intermediate epithelial layer still differentiated into ciliated and goblet cells. In addition to the appearance of neoplasms, hyperplastic and dysplastic changes of the tracheal epithelium were seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305027
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    Paper (German National Licenses)
    Fulltext
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