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  • 1
    Electronic Resource
    Electronic Resource
    Large B-cell lymphoma presenting with lytic bone lesions and hypercalcaemia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02068.x
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  • 2
    Electronic Resource
    Electronic Resource
    DNA flow cytometric analysis in renal neoplasms associated with acquired renal cystic disease (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to better understand the potential malignancy of renal neoplasms arising in patients with acquired renal cystic disease and to try and establish differences from other renal tumours we analysed DNA ploidy as well as the level of S-phase fraction in 11 neoplasms associated with acquired cystic disease by means of flow cytometry. The results were correlated with known prognostic factors such as nuclear grade, size and stage, as well as the clinical behaviour of the tumours. We found a close relationship between DNA aneuploidy and high S-phase fraction and a poor clinical outcome. We also found some differences in the DNA ploidy profile of these tumours when compared with those reported in other renal neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00642.x
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  • 3
    Electronic Resource
    Electronic Resource
    Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 44 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Adenosquamous carcinoma (ASC) of the head and neck is an unusual neoplasm in which a general consensus with regard to diagnostic criteria has not yet been reached. In this study we report the clinicopathological results of 12 ASCs, with special attention to their histological and immunohistochemical characteristics in order to define this neoplasm more precisely.Methods and results:  All the patients were male with a peak incidence in the sixth decade of life. The tumours were located most frequently in the larynx and oral cavity, followed by the nasal cavity and pharynx. ASCs had two distinct histological components. The most extensive one was an usual keratinizing squamous cell carcinoma, arising from the surface epithelium, where characteristically severe dysplasia or carcinoma in situ was found in all cases. The second component was an adenocarcinoma, usually displayed in the deepest areas of the tumour. Evidence of origin from salivary or seromucinous glands was not found. Immunohistochemical studies demonstrated in most cases positivity of glandular differentiated areas for carcinoembryonic antigen (CEA) (11/12), CK7 (9/12) and CAM5.2 (7/12), whereas the squamous cell component was unreactive or reacted only focally for these markers. High-molecular-weight cytokeratin 34BE12 was positive in both components and CK20 was always negative. All cases showed high expression of Ki67 antigen. Most of them had overexpression of p53 (8/12) and DNA aneuploidy (10/12). Fifty percent of patients with ASC died of disease after a mean period of 23 months (range 12–35 months).Conclusions:  ASC of the head and neck is an aggressive neoplasm that originates in the surface epithelium of the upper respiratory tract. Severe dysplasia or carcinoma in situ is usually found and its recognition helps to make the diagnosis. In addition to mucin stains, positive immunoreactivity for CEA, CK7 and CAM5.2 helps to identify the glandular component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01881.x
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  • 4
    Electronic Resource
    Electronic Resource
    Middle-ear adenoma (MEA): a report of two cases, one with predominant ‘plasmacytoid’ features (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 30 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Middle-ear adenomas (MEAs) are rare neoplasms which can display several histological patterns and represent a diagnostic challenge. We present two cases of MEA which share some histopathological features such as medium to small cells forming solid infiltrating tumour nests as well as scattered glandular structures with Alcian blue and PAS positive material within. The second case also displayed a distinct and predominant ‘plasmacytoid’ appearance which, in a small biopsy, might have been misleading. Both cases expressed an admixture of epithelial and neuroendocrine immunohistochemical markers, whereas ultrastructural study demonstrated electron dense granules. Taken together, these observations support a mixed epithelial and neuroendocrine nature for these neoplasms, the differential diagnosis of which includes paragangliomas and other tumours or tumour-like lesions involving less frequently the middle ear, such as meningiomas, plasmacytomas and inflammatory polyps. The existence of MEAs with plasmacytoid features should be remembered to avoid confusion with plasmacytomas, plasmacytoid myoepithelioma and plasma cell inflammatory infiltrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.d01-625.x
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  • 5
    Electronic Resource
    Electronic Resource
    High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases (1999)
    Springer
    Virchows Archiv 434 (1999), S. 291-299 
    Details
    ISSN: 1432-2307
    Keywords: Key words Epithelial myoepithelial carcinoma ; Salivary gland tumours ; Immunohistochemistry ; Flow cytometry ; MIB-1 (Ki 67) ; Proliferative markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Three cases of epithelial-myoepithelial carcinoma (EMC) with coexisting areas of high grade carcinoma are reported. In two of the cases there was a previous recurrence, and in all three patients there had been a sudden increase in size before final surgery. The typical ductal and myoepithelial components of EMC showed the usual biphasic pattern and the expected immunophenotypes, with expression of wide spectrum cytokeratins, Cam 5.2 and EMA in the ductal part, and muscle-specific actin, smooth muscle actin, S-100 protein, vimentin and cytokeratins in the myoepithelial component. These areas also had a low mitotic count and low proliferation rate as measured by immunohistochemistry and by flow cytometry. Conversely, areas of high-grade tumour had the features of a large cell carcinoma, with focal mucin secretion in two cases. This high-grade component showed an epithelial immunophenotype in two cases, and was negative for all tested markers in the third one. The mitotic counts and the proliferation rates were much higher in these anaplastic areas. One of the patients died 3 months after treatment; another developed lymph node metastases 1 year later and was alive after 6 years of follow-up. The third patient was alive without evidence of disease 7 months after wide surgical resection of the tumour. The possibility of anaplastic transformation in EMC makes thorough sampling mandatory in this type of neoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050344
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  • 6
    Electronic Resource
    Electronic Resource
    The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 98-107 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die kombinierte Verabreichung von Methylcholanthren (MCA) (intragastrisch) und Dimethylnitrosamin (DMN) (intraperitoneal) führte bei Swiss-Mäusen zu erhöhter Tumorrate bei verkürzter Latenzzeit im Vergleich zu Tieren, die jeweils nur mit einer der beiden Substanzen behandelt wurden. In der MCA+DMN-Gruppe fanden sich vermehrt Lungencarcinome, Neoplasmen der Nieren und Lymphome. Bei den Tieren der DMN-Gruppe zeigten sich gehäuft Gefäßtumoren. Die Befunde der MCA + DMN-Gruppe werden als syncarcinogene Wirkung der Substanzen diskutiert.
    Notes: Summary The combined application of MCA (i.g.) and DMN (i.p.) to Swiss mice resulted in an increased incidence of tumors and in a decreased tumor latency, compared with the animals treated with each compound alone. In the MCA+DMN group the rate of lung carcinomas and neoplasms of the kidney was found to be significantly enhanced, while the DMN group showed an increase of vascular tumors. In the MCA group malignant lymphomas were seen more frequently than in the other groups. The findings concerning the lung and kidney were interpreted as a syncarcinogenic effect of the combined application of MCA + DMN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284384
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  • 7
    Electronic Resource
    Electronic Resource
    Susceptibility of gerbils (meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-Diethylnitrosamine (1975)
    Springer
    Journal of cancer research and clinical oncology 83 (1975), S. 233-238 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach wöchentlicher subcutaner (24, 12 oder 6 mg/kg KG) und einmalig intravenöser (100 oder 50 mg/kg KG) Applikation von Diäthylnitrosamin (DEN) fanden sich bei mongolischen Rennmäusen (meriones unguiculatus) Tumoren des Respirationstraktes und der Leber. Am häufigsten wurden Carcinome im Bereich des Riechepithels der Nasenhöhle beobachtet, seltener Papillome im tracheobronchialen Epithel und Adenome oder Carcinome in den Lungen. Die Tumoren der Leber waren überwiegend cholangiocellulären und in einzelnen Tieren auch hepatocellulären Ursprungs.
    Notes: Summary Weekly s. c. (24, 12, and 6 mg/kg b. w.) or a single i. v. (100 or 50 mg/kg b. w.) injections of N-diethylnitrosamine (DEN) to gerbils (meriones unguiculatus) resulted in tumours of the respiratory tract and liver. Carcinomata of the nasal olfactory region or respiratory-olfactory mucosal junction were most common; papillomata of the tracheobronchial system and adenomata or carcinomata of the lungs appeared in significantly lower incidences. The neoplasms of the liver were of cholangiocellular and in an few cases of hepatocellular origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304093
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of nitroso compounds (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 229-233 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten als Einzeldosis subcutan Dimethyl-(DMN) oder Diäthylnitrosamin-(DEN). In statistisch gesicherter Abhängigkeit von der applizierten Carcinogenmenge beider Substanzen (je 5 Gruppen) zeigten sich beim Vergleich mit den Kontrollen jeweils ein Anstieg der Lungentumorhäufigkeit (ausgenommen die niedrigste DMN Dosis). Darüber hinaus fanden sich bei Tieren mit langer Überlebenszeit Sarkome an der Injektionsstelle. Die Ergebnisse lassen den Schluß zu, daß bei Untersuchungen an Mäusen mit minimalen Carcinogendosen neben dem Anstieg der Lungentumorrate auch andere Parameter Bedeutung haben.
    Notes: Summary A single subcutaneous injection of dimethyl-(DMN) or diethylnitrosamine (DEN) was administered to Swiss mice at five dose levels. A statistically significant increase in the incidence of lung tumours was observed at all dose levels for both compounds except for the group receiving the lowest dose of DMN. In addition, subcutaneous sarcomata developed late in life at the site of injection. These findings might indicate that the mouse assay of minimal carcinogenic levels of nitrosamines is pertinent not only for the lung tumour test, but also for other parameters namely those associated with longer survival rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305023
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  • 9
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of Nitroso compounds (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 251-259 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die onkogene Wirkung einer Einzeldosis von N-nitrosopiperidin und N-nitrosomorpholin wurde am Syrischen Goldhamster untersucht. Es fanden sich vorwiegend Neoplasmen im Respirationstrakt, wobei die Trachea besonders betroffen war. Wie ultrastrukturelle Beobachtungen bestätigten, stellten die Trachealtumoren Polypen dar. Zellen der Oberfläche von Tumoren wie auch der darunter liegenden epithelialen Anteile differenzierten sich noch in Flimmerepithelzellen und Schleimzellen. Neben der Tumorentstehung zeigten sich hyperplastische und dysplastische Veränderungen des Trachealepithels.
    Notes: Summary The oncogenic effects of a single dose of N-nitrosopiperidine and N-nitrosomorpholine were examined in Syrian golden hamsters. The main target organ was the respiratory system; the majority of neoplasms was found in the trachea. As ultra-structural investigations could confirm, the tracheal tumours were polyps. Surface lining tumour cells as well as cells in the intermediate epithelial layer still differentiated into ciliated and goblet cells. In addition to the appearance of neoplasms, hyperplastic and dysplastic changes of the tracheal epithelium were seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305027
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of intraperitoneal injections of dimethyl- and diethylnitrosamine, alone or simultaneously on Swiss mice (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 233-238 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
    Notes: Summary Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304061
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