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  • 1
    Electronic Resource
    Electronic Resource
    Lack of influence of glucagon on glucose homeostasis after prolonged exercise in rats (1977)
    Springer
    Pflügers Archiv 369 (1977), S. 21-25 
    Details
    ISSN: 1432-2013
    Keywords: Insulin ; Epinephrine ; Norepinephrine ; Glycogen ; Gluconeogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The significance of glucagon for post-exercise glucose homeostasis has been studied in rats fasted overnight. Immediately after exhaustive swimming either rabbit-antiglucagon serum or normal rabbit serum was injected by cardiac puncture. Cardiac blood and samples of liver and muscle tissue were collected before exercise and repeatedly during a 120 min recovery period after exercise. During the post-exercise period plasma glucagon concentrations decreased but remained above pre-exercise values in rats treated with normal serum, while rats treated with antiglucagon serum had excess antibody in plasma throughout. Nevertheless, all other parameters measured showed similar changes in the two groups. Thus after exercise the grossly diminished hepatic glycogen concentrations remained constant, while the decreased blood glucose concentrations were partially restored. Simultaneously concentrations in blood and serum of the main gluconeogenic substrates, lactate, pyruvate, alanine and glycerol declined markedly. During the post-exercise period NEFA concentrations in serum and plasma insulin concentrations remained increased and decreased, respectively, while plasma catecholamines did not differ from basal values. Muscle glycogen concentrations decreased slightly. These findings suggest that in the recovery period after exhaustive exercise the increased glucagon concentrations in plasma do not influence gluconeogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580805
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 287-293 
    Details
    ISSN: 1432-1041
    Keywords: Rifampicin ; induction of drug metabolism ; cirrhosis ; cholestasis ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased more than two-fold and that of tolbutamide almost two-fold. The results suggest that rifampicin is able to stimulate hepatic drug metabolism in patients with liver disease. It was apparent in general that the induction did not lead to improvement of hepatocellular function during disease as judged by laboratory findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607679
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Anti-androgen-therapy in pachydermia of the female larynx — a new therapeutic possibility (1977)
    Springer
    European archives of oto-rhino-laryngology and head & neck 215 (1977), S. 75-79 
    Details
    ISSN: 1434-4726
    Keywords: Larynx ; Pachydermia laryngis ; Anti-androgens ; Cyproteroneacetate ; Larynx ; Pachydermie ; Anti-Androgene ; Cyproteronazetat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über eine 56jährige Patientin mit Pachydermia laryngis und Hirsutismus berichtet, die erfolgreich mit dem Testosteron-Antagonisten Cyproteronacetat behandelt werden konnte. An Hand dieses Falles wird die Bedeutung androgener Hormone für die Genese von Epithelveränderungen am weiblichen Kehlkopf unterstrichen und die Anwendung antiandrogener Substanzen als neuartige therapeutische Möglichkeit diskutiert.
    Notes: Summary Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogenic substances as a new therapeutic measure is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463194
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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