ISSN:
1432-2048
Keywords:
Mitochondria
;
NADH oxidation
;
Rotenone-resistant respiration
;
Vicia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Mitochondria from Vicia faba L. exhibit two pathways for the oxidation of endogenous NADH. One pathway is rotenone-sensitive and includes three phosphorylation sites, the other one is rotenone-insensitive and by-passes site I. This by-pass is located in the area of flavoproteins, but several lines of evidence suggest that the rotenone-insensitive oxidation of matrix-NADH is not mediated by the external NADH dehydrogenase. With saturating substrate concentrations the two pathways are superimposed in state 3 while in state 4 the electrons are transferred only via the by-pass. The rotenone-resistant electron flux is obviously regulated from the substrate side. We suggest that the function of the by-pass is to regulate the NADH/NAD+ ratio of the matrix space.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00385124
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