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  • 1
    Electronic Resource
    Electronic Resource
    Coexistence of psoriasis and an unusual IgG-mediated subepidermal bullous dermatosis: identification of a novel 200-kDa lower lamina lucida target antigen (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Bullous pemphigoid (BP) is characterized by autoantibodies against 230- and 180-kDa hemidesmosomal antigens located in the most superficial layers of the basement membrane zone (BMZ). Histologically. there is a predominance of eosinophils in the infiltrate. In a psoriatic patient, we identified an unusual autoimmune subepidermal bullous eruption which clinically resembled BP, but which was characterized by IgG autoantibodies against a novel 200-kDa lower lamina lucida component, Histologically there was a predominance of neutrophils in the infiltrate.Direct immunofluorescence showed linear immunoglobulin (Ig)G and C3 deposition at the BMZ. The patient's IgG autoantibodies bound exclusively to the dermal side of salt-split normal human skin. Indirect immunogold electron microscopy showed a marked deposition of IgG at the lower lamina lucida and minimal deposition at the hemidesmosomes. Immunoblot analysis identified a unique 200-kDa autoantigen in dermal extracts and a faint band of the 230-kDa BP antigen in epidermal extracts. The patient responded dramatically well to cyclosporin A.Although the patient's serum also reacted slightly with the 230-kDa BP antigen, there were significant findings different from the usual immunopathological changes of BP. These included finding a novel 200-kDa lower lamina lucida target antigen, the binding of IgG autoantibodies exclusively to the dermal side of the split skin and a predominance of neutrophils in blister infiltrate. The IgG autoantibodies against the 200-kDa lamina lucida target antigen seemed to play a major role in the pathogenesis of this unique autoimmune subepidermal dermatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07625.x
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  • 2
    Electronic Resource
    Electronic Resource
    Expression and ultrastructural localization of HMB-45 antigen (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: HMB-45 is a monoclonal antibody specific for melanoma cells and premature developing melanocytes. We examined the expression and specific subcellular binding sites of HMB-45 in various types of melanocytes including epidermal melanocytes from fetuses and infants with or without tyrosinase-negative oculocutaneous albinism (type IA), melanin-producing and non-producing melanoma cell lines (G361 and MeWo), and in vivo melanoma cells (melanotic and amelanotic malignant melanoma). Subcellular HMB-45 binding was examined by using post-embedding immunogold electron microscopy with rapid freezing and freeze substitution fixation methods without the use of chemical fixatives to preserve the intracytoplasmic delicate antigen property of HMB-45. HMB-45 antigen was detected not only in in vivo melanoma cells and normal fetal melanocytes, but also in melanocytes in the other conditions. Post-embedding immunogold electron microscopy revealed that HMB-45 antigen was exclusively localized to stages I and III melanosomes in the melanocytes from fetuses and infants. In tyrosinase-negative oculocutaneous albinism, only stages I and II melanosomes were detected in the cytoplasm, but both stages of melanosomes were HMB-45 positive.We conclude that HMB-45 appears mainly on the immature melanosomes during melanogenesisin both neoplastic and non-neoplastic melanocytes regardless of their tyrosinase activity, but the intracytoplasmic localization of HMB-45 antigen is different by each condition of melanocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1012.x
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  • 3
    Electronic Resource
    Electronic Resource
    Reply (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07395.x
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  • 4
    Electronic Resource
    Electronic Resource
    Kindler's syndrome with recurrence of bullae in the fifth decade (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb01539.x
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  • 5
    Electronic Resource
    Electronic Resource
    An acquired bullous dermatosis due to an autoimmune reaction against uncein (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A 59-year-old male showed acquired. mechanically induced, scarring blisters on the fingers, toes, scalp and abdomen, as well as in the oral cavity. Ultrastructural and immunohistochemical examination of the bullae revealed junctional epidermal-dermal separation and lgG deposits in the lamina lucida of the basement membrane zone (BMZ). where the reactivity of the 19-DKJ-1 monoclonal antibody was decreased. Anti-BMZ autoantibodies detected in his serum were reactive to the lower lamina lacida region of normal human skin. SDS-PAGE of affinity purified antigens from human keratinocytes with IgG from the patient's serum revealed three polypeptide bands at 165, 135 and 1OO kDa. in reduced condition. The indirect immunofluorescence test of his serum was negative on skin cryosections from patients with lethal junctional epidermolysis bullosa. Pretreatment of normal human skin sections with the patient's serum, blocked the binding of 19-DEJ-1 monoclonal antibody but not that of the GB3 monoclonal antibody. This case is considered to be an acquired autoimmune bullous dermatosis due to an autoantibody reaction against uncein (19-DEJ-1 antigen). a component of anchoring filaments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.132867.x
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  • 6
    Electronic Resource
    Electronic Resource
    A case of linear IgA buUous dermatosis with IgA anti-type VII collagen autoantibodies (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In this study we present a patient with the sublamina densa type of linear IgA bullous dermatosis (LABD). with IgA autoantibodies reactive with the 290-kDa type VII collagen (the epidermolysis bullosa acquisita (EBA) antigen) and with immunoblotting of normal human dermal extracts. The clinical and histological features of the present case were compatible with those of LABI) but quite different from those of RBA. Although EBA sera reacted with the bacterial fusion protein of the N-terminal globular (NC1) domain of type VII collagen, this patient's serum did not show reactivity. Furthermore, ultrastructural localization of target epitopes on the anchoring fibrils in this patient was considerably different from EBA. These results indicate that, whereas EBA antibodies react with the NC1 domain of type VII collagen, the epitope in this case is different from that of EBA (and is most likely on the central triple helical domain). This difference may be responsible for the clinical presentation in this patient being distinct from that of EBA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07624.x
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  • 7
    Electronic Resource
    Electronic Resource
    Epidermolysis bullosa acquisita: report of a case with comparison of immunogold electron microscopy using pre- and postembedding labelling (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A patient with epidermolysis bullosa acquisita (EBA). who has been diagnosed as having bullous pemphigoid for 7 years, is reported. By immunoblotting, both the latest serum and a 4-year-stored serum sample of the patient, were shown to react with the 290-kDa EBA antigen or type VII collagen, but not with bullous pemphigoid antigens. Pre-embedding immunogold electron microscopy demonstrated that the serum bound to the ‘anchoring plaque’ and to both ends of the anchoring fibrils in the fashion reported previously. In contrast, postembedding immunoelectron microscopy showed binding mainly to the lamina densa. These results indicate that EBA antigens are localized mainly at the lamina densa. Further studies are necessary for confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-763.x
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  • 8
    Electronic Resource
    Electronic Resource
    Self-synchronization of nonlinear oscillations in the presence of fluctuations (1981)
    Springer
    Journal of statistical physics 26 (1981), S. 719-743 
    Details
    ISSN: 1572-9613
    Keywords: Self-synchronization ; Van der Pol oscillator ; fluctuations ; phase transition ; rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A statistical mechanical theory is presented for the self-organization of a macroscopic oscillation with the presence of external fluctuations in a system of Van der Pol oscillators coupled through dissipative interactions. Starting from Langevin equations for the Van der Pol oscillators, the static and dynamic characteristics are studied. The threshold condition is given by the relative size between the fluctuation and the interaction. The transitions between synchronous and asynchronous phases are well discussed by a Landau-type equation. The steady state value of the order parameter and the onset time are compared between the theory and the computer experiments and a good agreement is obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01010935
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  • 9
    Electronic Resource
    Electronic Resource
    Epidermal vacuolation: An artifact due to injection of local anesthetics (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 413-419 
    Details
    ISSN: 1432-069X
    Keywords: Epidermal vacuolation ; Local anesthetics ; Intradermal (i.d.) injection ; Subcutaneous (s.c.) injection ; Epidermale Vacuolisierung ; Lokalanaestheticum ; intradermale (i.d.) Injektion ; subcutane (s.c.) Injektion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um den Mechanismus der Vacuolisierung zu erklären, die man häufig in den normalen Epidermiszellen in der Umgebung der Hauttumoren beobachtet, wurden 0.5 und 1.0% Procainhydrochlorid mit und ohne Epinephrine injiziert — entweder i.d. oder s.c. — und zwar bei reifen weißen männlichen Kaninchen. Die Injektionsstellen entweder sofort oder nach 15 min excidiert. Die Epidermis zeigte an der Stelle der i.d. Injektion eine signifikantere Zunahme der Zahl der vacuolisierteten Zellen als die der s.c. Injektionen (P〈0.001) ohne Rücksicht auf die Art der Lokalanaesthetica und die Zeitdauer zwischen Injektion und Excision. Die Elektronenmikroskopie stellte die intracytoplasmischen Vacuolen ohne abgrenzende Membran im Cytoplasma der Keratinocyten dar. Das im oberem Corium lokalisierte Ödem infolge der Injektion des Betäubungsmittels verursacht das Ödem und die Vacuolisierung in den bedeckenden Epidermiszellen. Die i.d. Injektion des Lokalanaestheticums möchten wir als eine Ursache der epidermalen Vacuolisierung auffassen.
    Notes: Summary To elucidate the mechanism of vacuolation frequently encountered in the normal epidermal cells surrounding skin tumors, 0.5 and 1.0% procaine hydrochloride, and 1.0% lidocaine hydrochloride with and without epinephrine were injected either i.d. or s.c. into mature white male rabbits, and the sites of injection were biopsied either immediately or after 15 min. The epidermis of the site of intradermal injection showed a significant increase in the number of vacuolated cells in contrast to the site of s.c. injection (P〈0.001) irrespective of the kinds of local anesthetics and the time lapse from injection to biopsy. Electron microscopy revealed vacuole-formations without limiting membrane in the cytoplasm of the kerationocytes. It is suggested that the local edema in the upper dermis caused by injection of anesthetics gives rise to edema and vacuolation of overlying epidermal cells, and that i.d. injection of local anesthetics may be regarded as a cause of epidermal vacuolation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403785
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of Ca2+ and Mg2+ on motility of sea urchin spermatozoa (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 861-862 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Swimming speed of sea urchin spermatozoa, measured by a light scattering technique, did not change with 0-20 mM Ca2+ in the medium. The speed was maximum at the normal concentration of Mg2+ (49 mM) in sea water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985682
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