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  • 2000-2004  (2)
  • 1990-1994
  • 1980-1984  (4)
  • 2003  (2)
  • 1983  (4)
Material
Years
  • 2000-2004  (2)
  • 1990-1994
  • 1980-1984  (4)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 41 (1983), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Involvement of phosphate-activated glutaminase in Huntington's disease and agonal state was investigated in caudate nucleus and frontal cortex from postmortem brains. In Huntington's disease the activities of phosphate-activated glutaminase, glutamic acid decarboxylase, succinic dehydrogenase, choline acetyl-transferase, and acetylcholinesterase were significantly reduced in the caudate nucleus, but not in the frontal cortex. The activity of phosphate-activated glutaminase, and to a lesser extent of glutamic acid decarboxylase, was reduced in cases of terminal illness, as compared with cases of sudden death. Succinic dehydrogenase and choline acetyltransferase were reduced only in the few cases of prolonged and severe terminal illness. Enzyme activities of the caudate nucleus were more affected by agonal state than were those of frontal cortex. Results indicate that phosphate-activated glutaminase could be a useful marker of neuronal damage due to agonal state, and that phosphate-activated glutaminase and succinic dehydrogenase are reduced in Huntington's disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 33 (1983), S. 323-382 
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Patterns of variation were determined in anastomosis, pathotype and genotype of Colletotrichum lindemuthianum samples collected from individual plants of common bean cultivars from four locations in the Mexican highlands. In Chihuahua, 22 polymorphic AFLP bands in isolates taken from a single plant identified five distinct genotypes. In Michoacán, nine genotypes were identified based on a total of only six polymorphic bands. Combined cluster analysis of all isolates from individual plants grouped them geographically. In Chihuahua, in isolates from 16 individual plants, only nine genotypes were identified and all samples were found to belong to the same anastomosis group. However, analysis of selected isolates revealed two new pathotypes not reported previously from Chihuahua (races 449 and 467). In contrast, in Michoacán all 13 isolates from individual plants were found to have distinct genotypes, and in Mexico State only two pairs of isolates among 20 samples had identical genotypes. Although no pathotype variation was determined, five anastomosis groups were identified in Michoacán and three in Mexico State. These results suggest that patterns of variation in genotype and anastomosis groups are complex in the different locations sampled, and that no strong relationship exists between genotype, pathotype or anastomosis group.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  The Goseki grouping of gastric adenocarcinoma has been suggested as a possible prognostic factor. In those centres where it is used, it may be valuable to assess the Goseki grouping of a tumour on the initial diagnostic biopsy as well as on the resection specimen since it may in theory influence management. We examined the robustness of Goseki grouping of gastric adenocarcinoma in representative sections from resection and biopsy specimens in order to assess the consistency of agreement among a group of pathologists.Methods:  A single representative block from 100 gastric resection specimens was studied using a haematoxylin and eosin and mucin (alcian blue/periodic acid–Schiff) stain. These were circulated in batches to members of a group of 12 pathologists who each completed a simple proforma confirming the presence of carcinoma and assigning a Goseki group. In a second circulation the diagnostic biopsy specimen taken prior to resection was examined in the same way. This allowed comparison of the Goseki group of the biopsy and resection specimens.Results:  In both studies κ statistics showed good agreement on tubular differentiation of the carcinoma, but only moderate agreement for the intracellular mucin production, resulting in moderate agreement for the final Goseki group. Correlation between the Goseki group assigned on the biopsy and resected specimens was seen in 62% of the cases. However, the reproducibility was low (κ 0.375).Conclusions:  The Goseki grouping of resected gastric adenocarcinoma is reproducible and can be used in prognostication. Goseki grouping of biopsy specimens is of limited value in predicting the Goseki group assigned to the resected carcinoma.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Verteilung von Mannose-resistenten (MRHA) und Mannose-empfindlichen (MSHA) Fimbrien-Hämagglutininen wurde bei 482Escherichia coli-Stämmen untersucht; die Isolate stammten von 390 erwachsenen Frauen und 45 Schwangeren mit Harnwegsinfektionen verschiedener Art und von 47 gesunden Kontrollpersonen. Der Anteil von MRHA-Stämmen war bei Patienten mit symptomatischer Harnwegsinfektion (75%) signifikant höher als bei Frauen mit nicht signifikanter Bakteriurie (30%; p〈0,001). Schwangeren mit asymptomatischer Harnwegsinfektion (34%; p〈0,0001) und gesunden Kontrollpersonen (0%). Der Anteil von MSHA-Stämmen war bei Patienten mit symptomatischer Harnwegsinfektion signifikant geringer (22%) als bei Frauen mit nichtsignifikanter Bakteriurie (46%; p〈0,001) und Schwangeren mit symptomatischer Harnwegsinfektion (52%; p〈0,01). Nur 17% der Stämme von gesunden Kontrollpersonen wiesen MSHA-Aktivität auf. Bei Schwangeren mit Harnwegsinfektion war eine signifikante Assoziation zwischen der Infektion mit MRHA-Stämmen vonE. coli und einer früher durchgemachten Harnwegsinfektion nachzuweisen — unabhängig davon, ob klinische Symptome bestanden oder nicht. Bei Schwangeren mit anamnestisch erfaßter Harnwegsinfektion besteht somit eine siebenmal höhere Wahrscheinlichkeit, daß das Pathogen ein MRHA-tragender Keim ist als bei Frauen ohne entsprechende Vorgeschichte. Zwischen MRHA-Keimen und symptomatischer Infektion bestand ebenfalls eine signifikante Assoziation. Patienten mit klinisch manifester Harnwegsinfektion weisen ein sechsmal höheres Risiko für eine Infektion mit einem MRHA-Stamm auf als Patienten mit klinisch stummer Infektion.
    Notes: Summary The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains ofEscherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was significantly higher in patients with symptomatic UTI (75%) than in women with non-significant bacteriuria (30%, p〈0.001), pregnant women with asymptomatic UTI (34%, p〈0.001) and healthy controls (0%). The proportion of MSHA strains was significantly lower in patients with symptomatic UTI (22%) than in women with non-significant bacteriuria (46%, p〈0.001) and pregnant women with asymptomatic UTI (52%, p〈0.01). Only 17% of the strains from healthy controls had MSHA activity. In pregnant women with UTI, whether this was symptomatic or asymptomatic, there was a significant association between infection with MRHA strains ofE. coli and a past history of UTI. Thus, in a pregnant woman with an infection and a past history of UTI there is a seven-fold greater chance that this infection is due to an MRHA-bearing organism than in pregnant women without such a history. There was also a significant association between MRHA organisms and symptomatic infection. The risk of symptomatic patients having an infection with an MRHA strain is six times greater than that for a patient with a covert infection.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 6 (1983), S. 133-138 
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Faecal samples were collected from impounded stray dogs, classified as under or over six months of age, on their arrival in kennels and again 5–7 days later. The faeces were examined for the presence of campylobacters, salmonella andGiardia lamblia. No significant difference was found in the rate of isolation of these organisms between the two age groups. There was, however, a significant increase in the rate of isolation at days 5–7 compared with day 1. It is suggested that while dogs may acquire campylobacter infection in kennels, excretion of the organism may be intermittent and may be precipitated by stress. A low incidence of salmonellae andGiardia lamblia excretion was detected.
    Type of Medium: Electronic Resource
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