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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 154 (1995), S. 563-566 
    ISSN: 1432-1076
    Keywords: Key wordsStreptococcus ; pneumoniae ; Newborn ; Meningitis ; Septicaemia ; Pneumonia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A series of 11 cases of invasive infection with Streptococcus pneumoniae, occurring over an 11-year period, is reported. Eight of the 11 cases occurred during the final 2 years of the study suggesting that the incidence of infection may be increasing. Infection carries a high mortality (3/11). Morbidity includes meningitis, convulsions and respiratory failure. In one case S. pneumoniae meningitis occurred in both mother and newborn. Most mothers who carried the organism were asymptomatic at the time of delivery. Conclusion S. pneumoniae should be specifically sought in swabs taken from the pregnant mother and newborn and if isolated, even in the absence of symptoms, antibiotic therapy against the organism should be strongly considered.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: metoclopramide ; cancer chemotherapy ; high-dose ; emesis ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have carried out a randomized, double-blind trial to investigate the relationship between the dose and plasma concentration of metoclopramide and its anti-emetic efficacy and adverse effects in patients receiving cancer chemotherapy. Seventeen patients received four different infusion regimens of high-dose metoclopramide in random order with four consecutive courses of chemotherapy, to achieve an approximately eight-fold range in plasma metoclopramide concentrations. In patients receiving cisplatin the incidence of vomiting decreased with increasing metoclopramide dose, but the overall efficacy was poor. There was no relationship between anti-emetic efficacy and either dose or plasma concentration of metoclopramide in patients receiving cyclophospamide and doxorubicin. The adverse effects of high-dose metoclopramide included diarrhoea, which increased in incidence with increasing metoclopramide dose, and sedation and extrapyramidal reactions, which were not related to dose or plasma concentration. Although anti-emetic efficacy increases with increasing metoclopramide dose in patients receiving cisplatin, high-dose metoclopramide alone does not adequately control cisplatin-induced nausea and vomiting.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 28 (1973), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 25 (1970), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 29 (1974), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 31 (1976), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Verteilung von Mannose-resistenten (MRHA) und Mannose-empfindlichen (MSHA) Fimbrien-Hämagglutininen wurde bei 482Escherichia coli-Stämmen untersucht; die Isolate stammten von 390 erwachsenen Frauen und 45 Schwangeren mit Harnwegsinfektionen verschiedener Art und von 47 gesunden Kontrollpersonen. Der Anteil von MRHA-Stämmen war bei Patienten mit symptomatischer Harnwegsinfektion (75%) signifikant höher als bei Frauen mit nicht signifikanter Bakteriurie (30%; p〈0,001). Schwangeren mit asymptomatischer Harnwegsinfektion (34%; p〈0,0001) und gesunden Kontrollpersonen (0%). Der Anteil von MSHA-Stämmen war bei Patienten mit symptomatischer Harnwegsinfektion signifikant geringer (22%) als bei Frauen mit nichtsignifikanter Bakteriurie (46%; p〈0,001) und Schwangeren mit symptomatischer Harnwegsinfektion (52%; p〈0,01). Nur 17% der Stämme von gesunden Kontrollpersonen wiesen MSHA-Aktivität auf. Bei Schwangeren mit Harnwegsinfektion war eine signifikante Assoziation zwischen der Infektion mit MRHA-Stämmen vonE. coli und einer früher durchgemachten Harnwegsinfektion nachzuweisen — unabhängig davon, ob klinische Symptome bestanden oder nicht. Bei Schwangeren mit anamnestisch erfaßter Harnwegsinfektion besteht somit eine siebenmal höhere Wahrscheinlichkeit, daß das Pathogen ein MRHA-tragender Keim ist als bei Frauen ohne entsprechende Vorgeschichte. Zwischen MRHA-Keimen und symptomatischer Infektion bestand ebenfalls eine signifikante Assoziation. Patienten mit klinisch manifester Harnwegsinfektion weisen ein sechsmal höheres Risiko für eine Infektion mit einem MRHA-Stamm auf als Patienten mit klinisch stummer Infektion.
    Notes: Summary The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains ofEscherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was significantly higher in patients with symptomatic UTI (75%) than in women with non-significant bacteriuria (30%, p〈0.001), pregnant women with asymptomatic UTI (34%, p〈0.001) and healthy controls (0%). The proportion of MSHA strains was significantly lower in patients with symptomatic UTI (22%) than in women with non-significant bacteriuria (46%, p〈0.001) and pregnant women with asymptomatic UTI (52%, p〈0.01). Only 17% of the strains from healthy controls had MSHA activity. In pregnant women with UTI, whether this was symptomatic or asymptomatic, there was a significant association between infection with MRHA strains ofE. coli and a past history of UTI. Thus, in a pregnant woman with an infection and a past history of UTI there is a seven-fold greater chance that this infection is due to an MRHA-bearing organism than in pregnant women without such a history. There was also a significant association between MRHA organisms and symptomatic infection. The risk of symptomatic patients having an infection with an MRHA strain is six times greater than that for a patient with a covert infection.
    Type of Medium: Electronic Resource
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