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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of peanut lectin binding sites on human brain tumors as determined by peroxidase-antiperoxidase technique in paraffin sections (1983)
    Springer
    Acta neuropathologica 61 (1983), S. 21-26 
    Details
    ISSN: 1432-0533
    Keywords: Peanut lectin (PNL) ; Human brain tumors ; Granular cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peroxidase-antiperoxidase (PAP) technique was selected for visualizing the binding of peanut lectin (PNL) to the most frequent human brain tumors. The randomly selected material included neoplasms of neuroectodermal and mesenchymal origin. We employed 1–5 μm sections of routinely processed and paraffin-embedded tissues. PNL receptors were detected to a variable extent on the cell surface of astrocytoma, glioblastoma multiforme, oligodendroglioma, ependymoma, meningotheliomatous meningeoma, and plexus papilloma. In gliomas an increase in malignancy seems to be associated with a decrease in PNL binding. Except for the plexus papillomas, neuraminidase pretreatment had neither a qualitative nor a quantitative influence on the binding behavior of PNL. Intracellular PNL receptors could be detected in “granular cells” and in the perinuclear region of malignant gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688382
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Geochemical proximity indicators of massive sulphide mineralization in the Iberian Pyrite Belt and the East Pontic metallotect (1983)
    Springer
    Mineralium deposita 18 (1983), S. 387-398 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A comparative lithogeochemical study of mainly surface rocks of the Iberian Pyrite Belt (volcanic-sedimentary sequence) and the East Pontic metallotect (volcanic island arc system with few intercalations of marine sediments) has been performed in order to find facies-independent proximity indicators of massive sulphide mineralizations. As, Sb, Tl, and Na seem to be the most promising indicator elements for primary hydrothermal exhalation and/or alteration haloes. The size of the alteration haloes largely depends on the permeability of the country rocks and is best defined by ratios such as As/Na, Sb/Na, and Tl/Na.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206487
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Conspicuous enterocytic binding pattern for peanut lectin and malignant histiocytosis of the intestine (1983)
    Springer
    Virchows Archiv 399 (1983), S. 245-253 
    Details
    ISSN: 1432-2307
    Keywords: Coeliac disease ; peanut lectin ; malignant histiocytosis of the intestine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present a case of a 33 year old male with a history of early childhood diarrhoea and more recently diagnosed gluten sensitive enteropathy, who died with active disease, ulcerative proctosigmoiditis and desquamative erythrodermia associated with toxin induced shock. Autopsy revealed a tumour restricted to lymph nodes of the mesentery and the retroperitoneum. This is considered to be malignant histiocytosis of the intestine (MIH). Immunohistological examination of the diagnostic jejunal biopsy showed a pathological binding pattern for peanut lectin (PNL) within the enterocytes. This may be an expression of disturbed production or secretion of a product rich in non-reducing terminal D-galactosyl residues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619585
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The distribution of fibronectin in lymph nodes infiltrated by Hodgkin's disease (1983)
    Springer
    Virchows Archiv 400 (1983), S. 319-329 
    Details
    ISSN: 1432-2307
    Keywords: Hodgkin's disease ; Fibronectin ; Fibroblast ; Immunoperoxidase study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tissue distribution of fibronectin (FN) was examined using a commercial anti-FN serum, the peroxidase-anti-peroxidase (PaP) technique, and paraffin sections of 22 lymph nodes affected by Hodgkin's disease. Vascular basement membranes and reticulin fibres are selectively stained and their structural changes in this pathological condition become readily visible. In contrast to the normal lymph node and to Hodgkin's disease with lymphocytic predominance, cases of mixed cellularity disease contain individual and focally grouped cells displaying intracytoplasmic FN. In nodular sclerosis these cells with fibroblast morphology are consistently numerous in the marginal zones of the cellular nodes. Strongly reacting mastocytes probably absorbed the applied anti-serum non-immunologically. All the other cell types giving rise to the varying appearances of Hodgkin's lesions are consistently negative with respect to intracellular FN, including all forms of Hodgkin cells. We conclude that in Hodgkin's disease the immigration of FN-secreting fibroblasts is an integral part of the early sclerosing reaction, which in itself is a defence/repair mechanism closely related to scar formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00612193
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    Paper (German National Licenses)
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