ISSN:
1432-0533
Keywords:
Peanut lectin (PNL)
;
Human brain tumors
;
Granular cell
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Peroxidase-antiperoxidase (PAP) technique was selected for visualizing the binding of peanut lectin (PNL) to the most frequent human brain tumors. The randomly selected material included neoplasms of neuroectodermal and mesenchymal origin. We employed 1–5 μm sections of routinely processed and paraffin-embedded tissues. PNL receptors were detected to a variable extent on the cell surface of astrocytoma, glioblastoma multiforme, oligodendroglioma, ependymoma, meningotheliomatous meningeoma, and plexus papilloma. In gliomas an increase in malignancy seems to be associated with a decrease in PNL binding. Except for the plexus papillomas, neuraminidase pretreatment had neither a qualitative nor a quantitative influence on the binding behavior of PNL. Intracellular PNL receptors could be detected in “granular cells” and in the perinuclear region of malignant gliomas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688382
