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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 3580-3582 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A theoretical model to predict the gate tunnel current in metal–oxide–semiconductor structures has been developed by employing the nonparabolic E-k dispersion for describing the tunneling electron momentum. The tunnel electron effective mass mox and the Fermi energy in the gate have been used to fit the calculated tunnel current to the measured one. It is shown that in the direct tunneling regime the tunnel electron effective mass mox apparently increases with decreasing oxide thickness presumably due to the reduction of Si–O–Si bond angle in the compressively strained layer near the SiO2/Si interface, while in the Fowler–Nordheim tunneling regime mox remains constant at 0.50 m0. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1456-1457 
    ISSN: 1420-9071
    Keywords: Granulocyte ; complement ; immune adherence ; immune deposit ; glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sections of rat kidney with bovine serum albumin nephritis were incubated either with a single component of complement or with several components in sequence and then reacted with granulocytes. The average number of granulocytes bound to a nephritic glomerulus was elevated in sections incubated with C4 or C3 and increases were most significant when C14, C142 or C1423 were incubated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 157 (2000), S. 2303-2322 
    ISSN: 1420-9136
    Keywords: Key Words: GPS, crustal deformation, the Japanese islands, data assimilation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —A GPS array with about 1,000 permanent stations is under operation in Japan. The GPS array revealed coseismic deformations associated with large earthquakes and ongoing secular deformation in the Japanese islands. Based on daily coordinate data of the GPS stations, strain rate distribution is estimated. Most regions with a large strain rate are related to plate boundaries and active volcanoes. In addition, the Niigata-Kobe Tectonic Zone (NKTZ) is recognized as a region of large strain rate along the Japan Sea coast and in the northern Chubu and Kinki districts. This newly found tectonic zone may be related to a hypothetical boundary between the Eurasian (or Amurian) and the Okhotsk (or North America) plates. Precise observation of crustal deformation provides important boundary conditions on numerical modeling of earthquakes and other crustal activities. Appropriate computation methods of continuous deformation field are directly applicable to data assimilation for such numerical simulations.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-7799
    Keywords: Key words AST-120 ; Glomerulosclerosis ; Hyperlipidemia ; Renal failure ; SHC rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The oral adsorbent, AST-120 Kureha Chemical, has been shown to attenuate the progression of chronic renal failure in rats and humans. Spontaneous hypercholesterolemic male rats, (SHC rats; SHCRs) have been introduced for experimentation because they develop progressive hyperlipidemia and glomerulosclerosis on a cholesterol-free standard diet by their 30th week of life. Methods. The effects of AST-120 were studied in SHCRs. Twenty 10-week-old SHCRs were divided into two groups: a control group (n = 10), and an AST-120 group (n = 10). The experiment was begun at the 12th week and completed at the 34th week of life. Results. At the end of the experiment, we found that the serum levels of total cholesterol were 40% lower in the AST-120 rats than in the control rats (P 〈 0.01). The creatinine clearance in the AST group was 40% higher than that in the controls (P 〈 0.05). At the age of 20 weeks, postheparin lipoprotein lipase in the AST-120 SHCRs and in Sprague-Dawley rats with normal serum lipid levels was comparable, but was clearly lower in the control SHCRs. Finally, in a pathological investigation that determined a sclerosis index for all kidneys, this was significantly lower in the AST group than in the control animals (P 〈 0.01). Conclusions. The reduction of serum lipid levels following the administration of the AST-120 oral adsorbent is associated with amelioration of renal functional and structural changes in SHCRs.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Clinical and experimental nephrology 4 (2000), S. 156-159 
    ISSN: 1437-7799
    Keywords: Key words Human parvovirus B19 ; Hemolytic uremic syndrome ; Mesangiolytic glomerulonephritis ; Globotetraosyl ceramide (Gb4)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 59-year-old woman developed hemolytic uremic syndrome (HUS) associated with acute human parvovirus B19 (HPVB19) infection. A renal biopsy revealed glomerular mesangiolysis with segmental hypercellularity; mild fibrinogen/fibrin deposits were noted by immunofluorescence study and severe endothelial injury was noted electron microscopically. The histological findings were compatible with HUS. We discuss the relation of HPVB19 to HUS, with special reference to the tropism of the virus for endothelial cells.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0584
    Keywords: Keywords Immune thrombocytopenic purpura ; Intracranial hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We sent questionnaires to hospitals in Japan in order to study the incidence and conditions of intracranial hemorrhage (ICH) in children with immune thrombocytopenic purpura (ITP). From 1980 to 1995, 11 cases of ICH were reported in eight patients with ITP at 35 institutions. One patient had ICH four times, but only one patient died of the condition. From 1990 through 1995, ICH occurred in four (0.52%) of 772 patients with ITP. None of the patients died. The platelet count when ICH occurred was 5.2±3.7×109/l (mean±SD) (n=11). Four of the eight patients (1980–1995) had received active treatment [e.g. intravenous immunoglobulin G (i.v. IgG)] immediately before ICH occurred. In seven cases (1980–1995), possible causes of ICH, including menstruation (n=2) and viral infections (n=3), were identified. Systemic lupus erythematosus (SLE) later developed in three patients. Although the incidence of ICH in children with ITP has not decreased compared with the rates in earlier studies, the mortality rate has decreased markedly. Our results suggest that menstruation, infection, and risk factors for progression to SLE may help to predict ICH in children with ITP. Large-scale prospective trials are needed to identify risk factors for ICH.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-908X
    Keywords: Key words: MCP-1 – Macrophage infiltration – Neutrophil infiltration – IL-8 – LPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To evaluate the mechanism whereby monocyte chemoattractant protein (MCP)-1 attracts monocytes in vivo.¶Subjects: New Zealand white rabbits (175 rabbits) were used.¶Treatment: LPS, MCP-1 or IL-8 was injected into knee joints. Antibodies against various cytokines or IL-1 receptor antagonist were injected to neutralize cytokine activities.¶Methods: The numbers of leukocyte populations, levels of cytokines in joints were estimated.¶Results: Partial inhibition of neutrophil influx with anti-IL-8 IgG (10 μg) suppressed LPS-induced macrophage influx by 43 ± 8.5% (p〈0.05) without affecting the MCP-1 level. Intraarticular injection of MCP-1 (1-30 μg) induced macrophage influx. The event was accompanied by a small num-ber of neutrophils in an early phase. Co-injection of IL-8 (1.0 μg) enhanced the MCP-1-induced macrophage infiltration (p〈0.01). In neutrophil-deplete d rabbits, LPS failed to induce macrophage influx even though the MCP-1 level was maintained, and macrophage influx following exogenously administered MCP-1 was also dramatically inhibited.¶Conclusions: Early events associated with neutrophil infiltration appear to be important for MCP-1 to induce a later macrophage influx in LPS-arthritis.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 44 (2000), S. 24-30 
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract  In this research, we hypothesized that, in rats, adaptation to high altitude (2500 m) plus training at low altitude (610 m), ”living high–training low”, improves physical performance at low altitude more than living and training at low altitude (610 m). Rats were divided into four groups: (1) living at low altitude (LL, n=12), (2) living and training at low altitude (LLTL, n=13), (3) living at high altitude (LH, n=12), (4) living at high altitude and training at low altitude (LHTL, n=13). The program for living at high altitude involved raising rats under hypobaric hypoxia (equivalent to 2500 m), and the training program consisted of running on a tread-mill at low altitude. All groups were raised at each altitude and trained to run at 35 m/min for 40 min/day, 6 days/week for 6 weeks. During this program, we measured heart rates both at rest and during exercise, and performed running-time trials. The mean heart rate during exercise was lower in groups with training than in groups without training, and the groups receiving training could run longer than the untrained groups. The LHTL group especially showed the lowest mean heart rate during exercise and the longest running time among all groups. After 6 weeks of the training program, all rats had a catheter implanted into the carotid artery, and the mean systemic arterial pressure was continuously measured during treadmill running. The rate of increase of this pressure as the running intensity increased was lower in groups with training than in groups without training, especially in the LHTL group. Finally, we anesthetized all the rats and extracted both the right and left ventricles, and the triceps surae and liver. Training increased the weight of the left ventricle, triceps surae, and liver. The increase in weight of the left ventricle and triceps surae was higher in the LHTL group than in the LLTL group in particular. It appeared that living high– training low may be an effective strategy to improve performance ability at low altitude.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 144 (1985), S. 240-242 
    ISSN: 1432-1076
    Keywords: Idiopathic thrombocytopenic purpura ; Gamma globulin ; Methylprednisolone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In four children with chronic idiopathic thrombocytopenic purpura (ITP), high doses of gamma globulin or methylprednisolone were effective in increasing platelet counts transiently, yet there was no quantitative relationship between the platelet responses to these two therapies. This finding suggests a qualitative difference in the mechanisms of increasing platelets by the two drugs. High doses of gamma globulin and methylprednisolone showed a synergistic effect on the initial and maximal platelet responses, suggesting an intensification of the effect of gamma globulin by methylprednisolone. This combination therapy should be clinically useful, particularly in the control of acute haemorrhage or in preparations for emergency surgery.
    Type of Medium: Electronic Resource
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