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  • 1
    Electronic Resource
    Electronic Resource
    Sequential generation of cytokines during the initiative phase of inflammation, with reference to neutrophils (1998)
    Springer
    Inflammation research 47 (1998), S. 137-144 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Cytokine — Interleukins — Neutrophils — In vivo study — Inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Studies have suggested the role of cytokines in inflammation, as determined by results obtained in vitro, or with assessments of clinical samples. However, extrapolation of in vitro results to an in vivo situation must be made with caution, and findings obtained from clinical samples tend to lack a causal relation between cytokines and inflammatory responses. Animal models of inflammation can be useful in understanding roles of cytokines at sites of inflammation. We examined the production kinetics and cellular sources of tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-8, and IL-1 receptor antagonist (IL-1Ra), and obtained evidence for the involvement of these cytokines in a rabbit model of arthritis induced by lipopolysaccharide (LPS). We also attempted to analyze the inflammatory cytokine network among TNFα, IL-1β, IL-8, and IL-1Ra. Understanding the role of cytokines in animal models paves the way to a better understanding of disease in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050304
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  • 2
    Electronic Resource
    Electronic Resource
    Administration of neutralizing antibody against rabbit IL-1 receptor antagonist exacerbates lipopolysaccharide-induced arthritis in rabbits (1996)
    Springer
    Inflammation research 45 (1996), S. 479-485 
    Details
    ISSN: 1420-908X
    Keywords: IL-1 ; IL-1 receptor antagonist ; Anti-IL-1ra monoclonal antibody ; Lipopolysaccharide-induced arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endogenous IL-1 receptor antagonist (IL-1ra) may down-regulate part of IL-1 actions. We examined the participation of endogenous IL-1ra in the production of IL-1β in vitro. Macrophages cultured on adherent IgG produced a 100-fold molar excess of IL-1ra, compared with IL-1β. In the presence of a neutralizing monoclonal antibody (mAb) against rabbit IL-1ra, the production of antigenic IL-1β increased by 20–60%. Since the molar ratio of IL-1ra over IL-1 was 160- to 400-fold in synovial fluid (SF) of lipopolysaccharide (LPS)-induced arthritis, we examined the functional role of endogenous IL-1ra in the regulation of inflammatory responses. When measured in the presence of anti-IL-1ra mAb, masked IL-1 activity in SF became evident, with a 3- to 4-fold increment. The administration of anti-IL-1ra mAb with LPS into rabbit knee joints increased the IL-1 activity 4-fold and the production of antigenic IL-1β by 30–50%. The treatment also enhanced by 20–40% LPS-induced leukocyte infiltration and protein leakage. Therefore, endogenous IL-1ra apparently acts as a down-regulating factor for limiting delecterious effects of IL-1 by masking the biological activity and by inhibiting the production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252320
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  • 3
    Electronic Resource
    Electronic Resource
    Neutrophil infiltration as a crucial step for monocyte chemoattractant protein (MCP)-1 to attract monocytes in lipopolysaccharide-induced arthritis in rabbits (2000)
    Springer
    Inflammation research 49 (2000), S. 673-678 
    Details
    ISSN: 1420-908X
    Keywords: Key words: MCP-1 – Macrophage infiltration – Neutrophil infiltration – IL-8 – LPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To evaluate the mechanism whereby monocyte chemoattractant protein (MCP)-1 attracts monocytes in vivo.¶Subjects: New Zealand white rabbits (175 rabbits) were used.¶Treatment: LPS, MCP-1 or IL-8 was injected into knee joints. Antibodies against various cytokines or IL-1 receptor antagonist were injected to neutralize cytokine activities.¶Methods: The numbers of leukocyte populations, levels of cytokines in joints were estimated.¶Results: Partial inhibition of neutrophil influx with anti-IL-8 IgG (10 μg) suppressed LPS-induced macrophage influx by 43 ± 8.5% (p〈0.05) without affecting the MCP-1 level. Intraarticular injection of MCP-1 (1-30 μg) induced macrophage influx. The event was accompanied by a small num-ber of neutrophils in an early phase. Co-injection of IL-8 (1.0 μg) enhanced the MCP-1-induced macrophage infiltration (p〈0.01). In neutrophil-deplete d rabbits, LPS failed to induce macrophage influx even though the MCP-1 level was maintained, and macrophage influx following exogenously administered MCP-1 was also dramatically inhibited.¶Conclusions: Early events associated with neutrophil infiltration appear to be important for MCP-1 to induce a later macrophage influx in LPS-arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050645
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  • 4
    Electronic Resource
    Electronic Resource
    IL-8 is involved in homologous TNFα-, but not in IL-1β-induced neutrophil infiltration in rabbits (1997)
    Springer
    Inflammation research 46 (1997), S. 472-477 
    Details
    ISSN: 1420-908X
    Keywords: Key words: IL-8 — TNFα— IL-1β— IL-1 receptor antagonist — Neutrophil infiltration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We examined the involvement of IL-8 in TNFα and IL-1β neutrophil infiltration, using homologous reagents.¶Subjects: Female New Zealand white rabbits (n = 211).¶Methods: After injection of TNFα (1 μg) or rrIL-1β (300 pg) into rabbit knee joints, the leukocyte influx and the production of IL-8 were estimated. Anti-TNFα mAb, rrIL-1Ra, and anti-IL-8 IgG (10 μg each) were administrated simultaneously with either TNFα or IL-1β.¶Results: Administration of TNFα or IL-1β induced IL-8 production; both of which peaked at 1 h after the injection. Maximum neutrophil infiltration induced by TNFα was inhibited by 38–56% by anti-IL-8 IgG, 22–43% by rrIL-1Ra, and 77–83% by anti-IL-8 IgG plus rrIL-1Ra. In contrast, maximum neutrophil infiltration induced by IL-1β was not inhibited by anti-IL-8 IgG whereas anti-TNFα mAb reduced the infiltration by 68–75%.¶Conclusions: The involvement of IL-8 in TNFα- and IL-1β-induced neutrophil infiltration is limited. Factor(s) other than IL-8 appear to function as major neutrophil chemoattractants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050227
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  • 5
    Electronic Resource
    Electronic Resource
    Mitral regurgitation may be related with previous streptococcal infection (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 168-172 
    Details
    ISSN: 1432-1076
    Keywords: M protein ; Antibody ; Children ; Streptococcal infection ; Mitral regurgitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We measured anti M protein antibody (AMPA) titres in children with idiopathic mitral regurgitation (MR), streptococcal infection, rheumatic fever (RF), post-streptococcal acute glomerulonephritis (AGN) and normal healthy children. We investigated the association of MR with streptococcal infection and whether high AMPA titres can be used as persisting evidence of previous streptococcal infection. AMPA titres were measured with an enzyme-linked immunosorbent assay. We found significantly higher antibody titres in patients with MR and in streptococcal infection, RF, and AGN than in healthy controls. In the MR group (n=15), 54% patients had AMPA titres above the 90th percentile value that was found in normal controls. An elevated AMPA titre persisted for a long period even when the anti-streptolysin O titres had declined to normal in RF patients. Our data suggest that the high AMPA titres in MR should be further investigated to clarify the probable association with previous streptococcal infection. Conclusion High AMPA titre is a risk factor for developing complications after streptococcal infection. Our serological evidence suggests that in some patients. MR may be related to previous streptococcal infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953931
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  • 6
    Electronic Resource
    Electronic Resource
    Twenty-five types of T-cell receptor Vβ family repertoire in patients with Kawasaki syndrome (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 981-986 
    Details
    ISSN: 1432-1076
    Keywords: Key words Kawasaki syndrome ; Superantigen ; Reverse transcription PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, a possible relationship between Kawasaki syndrome (KS) and superantigen has been discussed since the report of selective expansion of specific Vβ family in the acute phase of KS. To further investigate the relationship between KS and superantigens, we examined 25 types of T-cell receptor Vβ family repertoire in patients with KS using the reverse transcription polymerase chain reaction. This is the first attempt to examine all of 25 Vβ families in KS. A non radioisotope method was used to quantify mRNA so that the experiment was safer, simpler, and faster. An expression index (EI) for each Vβ was defined as: (the amount of each Vβ mRNA)/(the sum of all Vβ mRNA) × 100. Ten patients with KS and ten normal children were studied. The Vβ9 and Vβ15 of acute phase of KS showed both significantly lower mean EI and significantly higher frequency of a decreased EI value as compared with control children. Selective expansion of the Vβ family in the patients with KS was not observed. Although highly increased EIs were observed in various Vβs, their frequency was not statistically significant. The pattern of increased Vβs did not show the specific pattern that indicates a particular superantigen. Conclusion In Kawasaki syndrome non-radioisotope method for analysing Vβ mRNA is useful in cases where many samples have to be handled. The depletion of Vβ9 and Vβ15 or highly increased expression index in the acute phase of Kawasaki syndrome might suggest a relationship to superantigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050982
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  • 7
    Electronic Resource
    Electronic Resource
    Cloning and sequence analysis of a cDNA for lymphocyte proliferation potentiating factor of rabbit polymorphonuclear leukocytes: Identification as rabbit interleukin 1β
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 150 (1988), S. 1237-1243 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(88)90761-9
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  • 8
    Electronic Resource
    Electronic Resource
    Leukoegresin: a Factor from Rabbit Skin associated with Leucocytic Emigration in the Arthus Reaction (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 977-978 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Arthus reactions were induced simultaneously in ten sites on an area measuring 15 x 12 cm on the clipped flanks of 2-2-3 kg rabbits sensitized with bovine serum albumin2. The increase in vascular permeability reached its peak in about 4-5 h2, leucocyte emigration in about 12 h1. The skin bearing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/218977b0
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibition of Anaphylactic Release of Vascular Permeability Factor or Histamine by Specific Protease Inhibitor in Tissue Culture (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 1007-1008 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Albino rabbits (2-2-3 kg) were immunized with five subcutaneous injections of 3 ml. bovine serum albumin (BSA) (25 mg/ml.; Armour)9. Explants 1 mm in diameter from the omentum of the animals were cultivated in our culture chamber which allowed simultaneous microscopic and chemical observation9. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2081007a0
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  • 10
    Electronic Resource
    Electronic Resource
    Purification of permeability factors mediating increased vascular response in cutaneous arthus-type inflammation
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 127 (1966), S. 172-178 
    Details
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(66)90487-9
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