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  • 2005-2009
  • 1995-1999
  • 1985-1989  (9)
  • 1985  (9)
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Materialart
Erscheinungszeitraum
  • 2005-2009
  • 1995-1999
  • 1985-1989  (9)
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Prostaglandin E2 Receptors on Human Peripheral Blood Monocytes (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The prostaglandin E2 (PGE2) receptor on human peripheral blood monocytes is characterized. The receptor binding at physiological temperature and pH was saturable, specific, and reversible. Scatchard analysis of binding data revealed a linear plot giving a Kd= 1.1 ± 10-9mol/l and Bmax=4.1 fmol/107 cells, equal to 240 binding sites per cell. PGE2 increased intracellular cyclic adenosine 5′-monophosphate by a maximal factor of 3. PGF2α and archidonic acid had no stimulatory effects on adenyl cyclase, in accordance with their low binding to the cells. The characterization of the PGE2 receptor on human monocytes creates a basis for the study of the clinical significance of changes in PGE2-receptor binding in disease states involving PGE2-monocyte interactions such as various immunological disorders and bone resorption.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01416.x
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of Cyclosporin A on Human Neutrophil and Monocyte Function (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effect of various concentrations of cyclosporin A (CyA), ranging from below peak blood levels to 20 times higher than blood levels of human peripheral blood polymorphonuclear and mononuclcar leukocytes, was examined. CyA was found to bind to neutrophils with Kd values in the range of 20-50 nM. CyA at clinically obtainable blood level concentrations had no effect on ncutrophil and monocyle chemotaxis, neutrophil oxidative burst, monocyte phagocytosis, or neutrophil bactericidal activity. The data on the release of lactoferrin. a secondary granule substance, from activated ncutrophils showed that the calcium ionophore A 23187-induced lactoferrin release was inhibited by treatment of cells with 4 μm CyA, whereas release of lactoferrin from zymosan- or phorbol myristatc acetate-activated nculropohils was not affected by the same concentration of CyA. This effect could either be due lo differences in the degree of cell membrane perturbation by the various activators or to calcium dependence of neutrophil activation. A third possibility may be that CyA acts at some subsequent steps in the release process of neutrophils. It is concluded that CyA does not interfere with important functions of human phagocytes, the cells that play a major role in the defence against invading microorganisms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01848.x
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  • 3
    Digitale Medien
    Digitale Medien
    Humoral Autoimmune Manifestation in Subacute Thyroiditis (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: To study the autoimmune manifestations in subacute thyroiditis (SAT), the patterns of thyroid antibodies, thyroglobulin and circulating immune complexes were investigated in 10 patients during the course of the disease. Eight patients were thyrotoxic at diagnosis, and became euthyroid during recovery with a median observation of 8 months (4–30 months). Thyroid stimulating immunoglobulins were measured as TSH binding inhibiting immunoglobulins (TBII) and as thyroid stimulating antibodies (TSAb). TBII were present in all patients at least once during the observation period and remained detectable in six patients after recovery. TSAb were detected in three patients without relation to the hyperthyroid state. Thyroglobulin antibodies (TgAb) were present in four patients and persisted in three, while microsomal antibodies (MAb) were negative. Thyroglobulin (Tg) in the TgAb negative patients (n = 6) was high at diagnosis (median 229 μg/1, range 55–375) and fell rapidly during the course of SAT. Circulating immune complexes (CIC), which were found in all patients, reached maximal levels shortly after the onset of the disease and persisted after recovery. No correlation could be demonstrated between the different thyroid antibodies, and there was no clear relation between the levels of CIC and presence of the autoantibodies. However, the changes in CIC paralleled the changes in TBII, and it is suggested that immune complex formation is a major feature of the regulatory mechanisms controlling the immune responses in SAT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb00889.x
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  • 4
    Digitale Medien
    Digitale Medien
    Monocyte chemotaxis in patients with nonseminomatous testicular carcinoma (1985)
    Springer
    Cancer immunology immunotherapy 19 (1985), S. 68-71 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The chemotactic responsiveness of blood monocytes was tested in 16 patients with nonseminomatous testicular carcinoma before, during, and after chemotherapy. All the patients initially had monocyte chemotaxis within the normal range. No correlation with the histology of the tumor, the clinical stage, or the presence in serum of α-fetoprotein and human chorionic gonadotropin was observed. Plasma from the patients did not inhibit the chemotaxis of normal monocytes, and serum from the patients contained no chemotactic factor inhibitor. During intensive chemotherapy with cis-platinum, bleomycin, and vinblastine a reversible defect in chemotaxis occurred without correlation to the development of fever. Two months after the completion of chemotherapy the chemotactic responsiveness was unchanged compared with pretreatment values. In conclusion, this study shows normal monocyte chemotaxis in patients with testicular carcinoma, which is in contrast to reports on a variety of other solid tumors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199315
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  • 5
    Digitale Medien
    Digitale Medien
    Van Buchem's disease and aneurysmal bone cyst (1985)
    Springer
    Archives of orthopaedic and trauma surgery 104 (1985), S. 65-68 
    Details
    ISSN: 1434-3916
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird das Vorkommen einer aneurysmatischen Knochenzyste im Bereich des rechten Hüftgelenkes bei einem Patienten mit Hyperostosis corticalis generalisata van Buchem beschrieben. Unter Hinweis auf die extreme Seltenheit sowohl der primären Knochensystemerkrankung (van Buchem) und ihre Kombination mit einer aneurysmatischen Knochenzyste werden die klinischen, radiologischen und laborchemischen Merkmale diskutiert.
    Notizen: Summary A patient suffering from Van Buchem's disease combined with an aneurysmal bone cyst in the para-acetabular region is described. The extreme rarity of both the primary disease and its combination with an aneurysmal bone cyst is discussed with respect to the clinical, radiological, and laboratory features.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00449961
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  • 6
    Digitale Medien
    Digitale Medien
    Positron studies of hydrogen-defect interactions in proton irradiated molybdenum (1985)
    Springer
    Applied physics 36 (1985), S. 81-92 
    Details
    ISSN: 1432-0630
    Schlagwort(e): 78.70 B ; 61.80 J
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Molybdenum single crystals are irradiated at 20 K with 6 MeV protons. The radiation damage and lattice defect annealing is studied by positron lifetime spectroscopy in the temperature range from 15 to 720 K. Loss of vacancies due to recombination with mobile interstitials is observed at 40 K (Stage I) in agreement with resistivity measurements. This is the first time Stage I is observed by positrons below 77 K. The implanted hydrogen decorates the vacancies around 100 K, which is consistent with a hydrogen migration energy in molybdenum:E M H = 0.3–0.4 eV. Clustering of spatially correlated vacancies takes place in a wide temperature region below the usual vacancy clustering stage (Stage III). Stage III is observed at rather low temperatures (400–480 K) due to the very high vacancy concentration. Hydrogen bound to vacancies and vacancy clusters is released above 540 K, which puts an upper limit to the hydrogen binding energy:E B H ≦1.4 eV. The present work emphasizes the advantage of employing a vacancy sensitive technique to study hydrogen in metals, where its intrinsic solubility is low. In such metals (as molybdenum) both the effective solubility and the effective mobility of hydrogen are strongly influenced by the presence of vacancies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00620613
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  • 7
    Digitale Medien
    Digitale Medien
    Abell 1367 and 1060 observed with EXOSAT (1985)
    Springer
    Space science reviews 40 (1985), S. 669-673 
    Details
    ISSN: 1572-9672
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Summary Two clusters of galaxies have been observed with EXOSAT to map the distribution of cool gas. For A1367 we have detected the two brightest sources found by EINSTEIN. We confirm the identification of a X-ray source with a blue object near NGC3842. By comparing the EXOSAT and the EINSTEIN count rates we can state, either that the source is variable, or that the HI column density is low and the spectrum is either a power-law with a spectral index 〉 1.5 or thermal with a temperature below 6×106 K. For A1060 we confirm the classification from optical data of NGC3311 as the dominant galaxy but we find no evidence for a central source as inferred from the EINSTEIN data. We derive an accretion rate of ∼10Mo/yr.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00179885
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  • 8
    Digitale Medien
    Digitale Medien
    119Sn Mössbauer study of the implantation behaviour of119In,119Sn,119mSn,119Sb and119mTe ions in SiC (1985)
    Springer
    Hyperfine interactions 23 (1985), S. 17-42 
    Details
    ISSN: 1572-9540
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The implantation behaviour of stable119Sn+ ions and radioactive119In+,119mSn+,119Sb+ and119mTe+ ions in SiC has been investigated by, respectively, conversion-electron Mössbauer spectroscopy on the 24 keV transition of119Sn, and by Mössbauer emission spectroscopy on the 24 keVγ radiation emitted by the119Sn daughter after the decays of the radioactive isotopes. The Mössbauer spectra could be decomposed in most cases into two groups of lines, one originating from119Sn atoms on substitutional Si sites, the other from various Sn-vacancy complexes distinguished by their Mössbauer parameters. Annealing experiments reveal a strong dependence of the structure of the defects and the formation and annealing kinetics on the chemical nature of the impurities. Defects formed in 297 K implantations with119mSn and119Sb anneal above 500
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02060136
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  • 9
    Digitale Medien
    Digitale Medien
    Internal oxidation of 5sp impurities in noble metals (1985)
    Springer
    Hyperfine interactions 23 (1985), S. 43-63 
    Details
    ISSN: 1572-9540
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The internal oxidation of ion-implanted radioactive119In,119Cd, and119Sb in high-purity (5N) copper, silver, and gold single crystals has been investigated. The formation of the impurity-oxygen defect structures was monitored by Mössbauer emission spectroscopy on the 24 keVγ-radiation from the daughter119Sn after theΒ-decay of the implanted radioactive isotopes. Molecule-like complexes are formed consisting of the implanted impurity and several oxygen atoms. The various Mössbauer parameters (isomer shift, quadrupole splitting, and Debye temperature) enable a distinction between different Sn-IV and Sn-II complexes, as well as between substitutional and vacancy-associated Sn atoms, which result from the ion implantations. The evolution of oxygen complexes with temperature during isochronal annealing was studied in the temperature range 300–1000 K. The formation (around 500 K) and the disintegration (around 900 K) of the complexes, in' silver in particular, are explained on the basis of diffusion properties of oxygen. A comparison of results from oxidations due to either thermal diffusion of oxygen or due to recoil implantations from a surface-oxide layer indicates that Sn-IV complexes are invariably formed in the first case, whereas in the latter case, a mixture of Sn-IV and Sn-II complexes is formed. Relations of the present results to similar results from PAC measurements on111Cd in silver and from Mössbauer experiments on AgSn alloys are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02060137
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