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Digitale Medien

Pharmacokinetic study of IV infusions of adriamycin (1985)

Eksborg, S. ; Strandler, H. -S. ; Edsmyr, F. ; [weitere]

Springer

European journal of clinical pharmacology 28 (1985), S. 205-212

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Details

ISSN: 1432-1041

Schlagwort(e): adriamycin ; cancer patients ; infusion ; pharmacokinetics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31–85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a more than 3-fold individual variation. The pharmacokinetics of adriamycin was linear. There was no pharmacokinetic rational for variation of the dose with the age of the patients. There was good agreement between the measured plasma concentration-time curves for prolonged infusions and curves predicted from pharmacokinetic data from short term infusions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00609693

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