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  • 1985-1989  (5)
  • 1987  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Systemic and regional vascular effects of atrial natriuretic peptide in a rat model of chronic heart failure (1987)
    Springer
    Basic research in cardiology 82 (1987), S. 517-529 
    Details
    ISSN: 1435-1803
    Keywords: atrial natriuretic peptide ; heart failure ; regionalblood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To characterize the systemic and regional vascular effects of atrial natriuretic peptide (ANP) in chronic heart failure, central hemodynamics, regional blood flow and plasma ANP levels were determined in a rat model of myocardial infarction and failure and in sham-operated animals. Measurements were made in the conscious state before and after intravenous rANP [99-126] (8 μg bolus followed by continuous infusion of 1.0 μg/kg/min). With this protocol, ANP significantly decreased cardiac output, right atrial, left ventricular enddiastolic and arterial pressures and there were increases in heart rate, systemic and intestinal vascular resistances in sham animals. Renal blood flow per gram of tissue was unchanged with ANP, but when expressed as a percentage of cardiac output, increased significantly, indicating a preferential renal vasodilatory effect of ANP. In rats with infarction and failure, this dose did not alter cardiac output or arterial pressure, but decreased right atrial and left ventricular blood flow. Although significantly reduced as compared to the control group, renal blood flow was not improved with ANP in the heart failure group. ANP plasma levels of the heart failure group were elevated at baseline (p〈0.01), and increased 5–10 times after infusion of rANP. Thus, in rats with chronic heart failure, the renal vascular effects of ANP are blunted, which may, in part, explain the failure of ANP to restore the altered volume homeostasis in heart failure despite elevated ANP plasma levels. However, the effects on venous return were preserved which, in turn, improved cardiac performance via a reduction of preload.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907221
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of long-term oral levodopa therapy in chronic congestive heart failure (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 1087-1094 
    Details
    ISSN: 1432-1440
    Keywords: Levodopa ; Inotropic drugs ; Congestive heart failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the long-term effects of orally administered levodopa, 11 patients with chronic congestive heart failure (NYHA III–IV) were studied during maintenance therapy (30±1 days) and after withdrawal from levodopa. The daily levodopa dose was 4 g in six patients; because of side effects the levodopa dose was reduced to 2–3 g in the remaining patients. After withdrawal of levodopa, mean pulmonary capillary wedge pressure and mean right atrial pressure increased significantly (from 19±2 to 24±3 and from 7±2 to 9±2 mmHg, respectively). Effective renal plasma flow was 329±57 during levodopa therapy and decreased significantly to 252±27 ml/min after withdrawal of levodopa. The number of ventricular premature contractions and couplets increased during levodopa therapy and decreased again significantly after withdrawal of levodopa. No significant differences between on and off levodopa were observed in resting heart rate, arterial blood pressure, cardiac index, stroke work index, systemic vascular resistance, sodium and water excretion, or creatinine clearance. Seven patients improved on levodopa therapy by one NYHA class; four of these seven patients deteriorated again by one NYHA class after withdrawal of levodopa. Regarding both clinical and hemodynamic changes after withdrawal of levodopa, three patients were classified as responders to long-term levodopa therapy. All three responders received 4 g levodopa per day. Average dopamine plasma level was 5.3±0.8 ng/ml in the responder group and 2.0±0.5 ng/ml in the nonresponder group. Long-term administration of oral levodopa is associated with beneficial clinical and hemodynamic response in only a minority of patients with chronic congestive heart failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736115
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Einfluß von Pseudomonas-Immunglobulin auf die antibakterielle Aktivität menschlicher Phagozyten (1987)
    Springer
    Infection 15 (1987), S. S42 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Thein vitro influence of a pseudomonas immunoglobulin in active and inactivated serum on the bactericidal activity and phagocytosis of human polymorphonuclear leukocytes was evaluated againstPseudomonas aeruginosa. No lysis of the bacteria could be found in either serum, however, the bactericidal activity of the leukocytes was significantly enhanced in active serum (p ≤ 0,05), whereas no effect was measurable in inactivated serum. Phagocytosis could be increased in concentrations of 10% immunoglobulin, (equivalent to 5 mg IgG/ml); however, a concentration of 15% showed a lower phagocytosis index which was comparable to that in the 5% preparation. This immunoglobulin proved to be able to support the bacterial phagocytosis and killing ofP. aeruginosa by human polymorphonuclear leukocytesin vitro.
    Notes: Zusammenfassung Untersucht wurde der Einfluß eines Pseudomonas-Immunglobulins auf dieIn vitro-Bakterizidie, Phagozytose und Abtötung vonPseudomonas aeruginosa durch menschliche polymorphkernige neutrophile Leukozyten in aktivem und inaktivem Serum. In aktivem Serum führte das Immunglobulin zu keiner Bakteriolyse, jedoch wurde die Leukozyten-Bakterizidie verstärkt (p ≤ 0,05); in inaktivem Serum war kein Einfluß meßbar. Die Phagozytose wurde sowohl in aktivem als auch in inaktivem Serum bis zu einer Volumenkonzentration von 10%, entsprechend 5 mg IgG/ml gesteigert, 15% zeigte dagegen eine geringere, der von 5% entsprechende, Wirkung. Somit war das Immunglobulin aufgrund seiner hohen Antikörper-Konzentration in der Lage, auchin vitro die Abtötung vonP. aeruginosa durch menschliche polymorphkernige neutrophile Leukozyten zu verstärken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644191
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Einfluß von Pseudomonas-Immunglobulin auf die antibakterielle Aktivität menschlicher Phagozyten (1987)
    Springer
    Infection 15 (1987), S. 51-55 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Thein vitro influence of a pseudomonas immunoglobulin in active and inactivated serum on the bactericidal activity and phagocytosis of human polymorphonuclear leukocytes was evaluated againstPseudomonas aeruginosa. No lysis of the bacteria could be found in either serum, however, the bactericidal activity of the leukocytes was significantly enhanced in active serum (p≤0,05), whereas no effect was measurable in inactivated serum. Phagocytosis could be increased in concentrations of 10% immunoglobulin, (equivalent to 5 mg IgG/ml); however, a concentration of 15% showed a lower phagocytosis index which was comparable to that in the 5% preparation. This immunoglobulin proved to be able to support the bacterial phagocytosis and killing ofP. aeruginosa by human polymorphonuclear leukocytesin vitro.
    Notes: Zusammenfassung Untersucht wurde der Einfluß eines Pseudomonas-Immunglobulins auf dieIn vitro-Bakterizidie, Phagozytose und Abtötung vonPseudomonas aeruginosa durch menschliche polymorphkernige neutrophile Leukozyten in aktivem und inaktivem Serum. In aktivem Serum führte das Immunglobulin zu keiner Bakteriolyse, jedoch wurde die Leukozyten-Bakterizidie verstärkt (p≤0,05); in inaktivem Serum war kein Einfluß meßbar. Die Phagozytose wurde sowohl in aktivem als auch in inaktivem Serum bis zu einer Volumenkonzentration von 10%, entsprechend 5 mg IgG/ml gesteigert, 15% zeigte dagegen eine geringere, der von 5% entsprechende, Wirkung. Somit war das Immunglobulin aufgrund seiner hohen Antikörper-Konzentration in der Lage, auchin vitro die Abtötung vonP. aeruginosa durch menschliche polymorphkernige neutrophile Leukozyten zu verstärken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646123
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Effect of stenotic geometry on flow behaviour across stenotic models (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 543-550 
    Details
    ISSN: 1741-0444
    Keywords: Haemodynamics ; Rheology ; Stenotic models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract In the study the influence of the geometry of stenoses on poststenotic flow characteristics such as faminar flow, separation, flow instabilities and local turbulences were assessed. Stenoses were represented by 12 rigid-walled models. The different geometric characteristics were length, percentage lumen area reduction, exit angle and eccentric location of the residual lumen. The flow characteristics were investigated by visualising the flow pattern with a birefringent solution and by measuring the flow and the pressure drop along the stenoses. All data were obtained under steady flow conditions for Reynolds numbers varying from approximately 1 to 500. In stenoses with short and concentric shapes local turbulence develops at Reynolds numbers well below the corresponding Reynolds numbers obtained in stenoses with the same percent lumen area reduction but with a long and eccentric shape. The results indicate that the photoelastic technique is a suitable method of obtaining a picture of the overall flow field downstream of a constriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441747
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    Paper (German National Licenses)
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