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  • 2005-2009  (2)
  • 1985-1989  (6)
  • 2005  (2)
  • 1988  (6)
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  • 2005-2009  (2)
  • 1985-1989  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    Patients’Experience of Transvaginal Follicle Aspiration under Local Anesthesia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 541 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb22249.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative Measurement of the Levels of Melanocortin Receptor Subtype 1, 2, 3 and 5 and Pro-Opio-Melanocortin Peptide Gene Expression in Subsets of Human Peripheral Blood Leucocytes (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 61 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Levels of the melanocortin receptor (MCR) 1, 2, 3 and 5 subtypes and pro-opio-melanocortin (POMC) protein mRNA were measured by the real-time quantitative reverse transcriptase polymerase chain reaction method in CD4+ T helper (Th) cells, CD8+ T cytotoxic cells, CD19+ B cells, CD56+ natural killer (NK) cells, CD14+ monocytes and CD15+ granulocytes from healthy donors. We found high levels of all of the MC1, 2, 3 and 5R subtype mRNA in Th cells and moderate levels in NK cells, monocytes and granulocytes. POMC peptide mRNA was found in all examined leucocyte subsets, but only low levels were present in granulocytes. Our findings suggest a co-ordinating role for MCR subtypes and their naturally occurring ligands in the co-operation between innate and adaptive immunity. Moreover, our findings are compatible with earlier finding of MCR-mediated tolerance induction in Th cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01565.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Urinary inflammatory mediators and inhalation of hypertonic saline in children (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The inflammatory mechanisms of hypertonic saline-induced bronchoconstriction are not well understood.Methods:  Seventeen asthmatics with (n = 11) and without bronchial hyperresponsiveness (BHR) (n = 6) and 18 randomly selected nonatopic nonasthmatic controls without BHR were evaluated by urine samples collected before and 1 h after hypertonic saline provocation test. Histamine, 11β-PGF2α, and LTE4 were analysed by enzyme immunoassay (EIA) and eosinophil protein X (EPX) by radioimmunoassay (RIA).Results:  The levels of leukotriene E4 (LTE4) increased significantly after the challenge tests, both in the asthmatics (median: 354 pg/mg pre-challenge vs. 628 pg/mg post-challenge; P = 0.05) and in the controls (median: 294 pg/mg pre-challenge vs. 460 pg/mg post-challenge; P 〈 0.01). The levels of histamine also increased significantly in the latter (median: 299 μmol/mg pre-challenge vs. 569 μmol/mg post-challenge; P = 0.03). However, the levels of 11β-PGF2α and EPX did not change significantly after the challenge tests either in the asthmatics or in the controls.Conclusions:  The inhalation of hypertonic saline increased urinary excretion of LTE4 both in the asthmatics and in the controls. The slight increase of leukotrienes was enough to induce airway obstruction in some of the asthmatics, because of the hyperresponsiveness in their airways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00623.x
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  • 4
    Electronic Resource
    Electronic Resource
    Measurement of ammonium utilization byEscherichia coli under ammonium limitation by means of an ammonia-sensitive semiconductor device (1988)
    Springer
    Applied microbiology and biotechnology 29 (1988), S. 269-274 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The concentration of ammonium in the medium of anEscherichia coli fermentation during ammonium limitation was followed by means of a newly developed semiconductor device, the ammonia gas-sensitive thin platinum metal oxide semiconductor structure (Pt-TMOS). It has been shown that the ammonia sensitivity of the sensor was sufficient for determination of ammonium concentrations at growth limitation due to ammonium depletion. Furthermore, the corresponding ATP concentration and dissolved oxygen tension during the progress of the fermentation was followed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00939320
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  • 5
    Electronic Resource
    Electronic Resource
    Measurement of ammonium utilization byEscherichia coli under ammonium limitation by means of an ammonia-sensitive semiconductor device (1988)
    Springer
    Applied microbiology and biotechnology 29 (1988), S. 269-274 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The concentration of ammonium in the medium of anEscherichia coli fermentation during ammonium limitation was followed by means of a newly developed semiconductor device, the ammonia gas-sensitive thin platinum metal oxide semiconductor structure (Pt-TMOS). It has been shown that the ammonia sensitivity of the sensor was sufficient for determination of ammonium concentrations at growth limitation due to ammonium depletion. Furthermore, the corresponding ATP concentration and dissolved oxygen tension during the progress of the fermentation was followed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982915
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The evolution of flowers with deep corolla tubes (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 147-149 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Floral design ranges from open dish-shaped to stereomorphic with tubes exceeding 30 cm. In "On the Origin of Species', p. 95, Darwin2 reported that certain length relations between the cor-rolla of red clover and the tongue of bees were crucial for successful mutualism and that by the survival of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334147a0
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  • 7
    Electronic Resource
    Electronic Resource
    Stereoselective binding of 11C-raclopride in living human brain — a search for extrastriatal central D2-dopamine receptors by PET (1988)
    Springer
    Psychopharmacology 94 (1988), S. 471-478 
    Details
    ISSN: 1432-2072
    Keywords: PET ; Dopamine receptor ; Brain ; Raclopride ; Stereoisomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selective D2-dopamine receptor antagonist raclopride and its pharmacologically inactive (R)-enantiomer FLB472 were labelled with 11C and used in a study with positron emission tomography to examine the stereoselectivity of 11C-raclopride binding to central D2-dopamine receptors in three healthy men. After the injection of 11C-raclopride, there was a high accumulation of radioactivity in the dopamine-rich basal ganglia, whereas after the injection of 11C-FLB472 there was no such accumulation of radioactivity. Thus, the binding of 11C-raclopride is stereoselective. Distribution ratios [radioactivity in a brain region/“free” (not protein-bound) radioactivity in plasma] were calculated for the two enantiomers to study regional differences in the accumulation of radioactivity. The distribution ratios in white matter were similar for the two enantiomers. In the putamen, a three to four-fold higher distribution ratio was found for 11C-raclopride than for 11C-FLB472, reflecting the presence of specific binding of 11C-raclopride binding to D2-dopamine receptors in the basal ganglia. In the temporal and frontal cortices the distribution ratios were, however, only a few per cent higher for 11C-raclopride than for 11C-FLB472, indicating that if D2-dopamine receptors are present in the human neocortex, then their density is indeed very low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212840
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulations of ribonuclease T1 (1988)
    Springer
    European biophysics journal 16 (1988), S. 287-297 
    Details
    ISSN: 1432-1017
    Keywords: Ribonuclease T1 ; protein dynamics ; molecular dynamics ; protein-nucleic acid interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Molecular dynamics simulations in vacuum and with a water sphere around the active site were performed on the 2′GMP-RNase T1 complex. The presence of water led to the maintenance of the 2′-GMP-RNase T1 interactions as compared to the X-ray structure, including the hydrogen bonds implicated in the enzyme-inhibitor recognition process. The sidechain of His92 in the molecular dynamics water simulation, however, hydrogen bonds directly to the phosphate of 2′GMP in contrast to the X-ray structure but in support of the role of that residue in the enzyme's catalytic mechanism. Fluctuations of activesite residues are not strongly influenced by water, possibly owing to the exclusion of water by the bound 2′GMP, which did show an increase in mobility. Analysis of the 2′GMP-RNase T1 interactions versus time reveal an equilibrium fluctuation in the presence of water, leading to a less favorable 2′GMP-RNase T1 interaction energy, suggesting a possible relationship between picosecond fluctuations and inhibitor dissociation occurring in the millisecond time domain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254065
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    Paper (German National Licenses)
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