ISSN:
1432-0533
Keywords:
Malignant lymphoma
;
Brain tumor
;
Non-Hodgkin lymphoma
;
Immunoglobulin
;
Gene rearrangement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Using the Southern blot hybridization technique, four cases of the primary malignant lymphomas of the brain, histologically diffuse large cell lymphoma, were examined for the immunoglobulin gene rearrangements. In three lymphomas, the rearrangements were observed in both heavy and light chain genes, providing strong evidence for a B cell lineage of these tumors. On the other hand, in the remaining lymphoma, the rearrangement was observed only in the heavy chain gene. Despite this, immunohistochemical examination revealed positive stainings for heavy and light chain immunoglobulins in tumor cells, suggesting the occurrence of light chain gene rearrangement at the undetectable level. Thus, B lymphocytic differentiation at the gene level was demonstrated in three, or possibly all, of the primary intracerebral malignant lymphomas examined. Since no more than two rearrangements were detected in each immunoglobulin gene, these lymphomas were considered to be monoclonal in nature.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00308952
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