Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2005-2009
  • 2000-2004
  • 1990-1994  (2)
  • 1990  (2)
  • Pharmacokinetics  (1)
  • Tumor resection  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 16 (1990), S. 448-453 
    ISSN: 1432-1238
    Keywords: Ceftriaxone ; Pharmacokinetics ; Acute renal failure ; Intensive care patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum concentrations of ceftriaxone (RocephinTM), a third generation cephalosporin, were monitored in 5 operative intensive care patients suffering from acute renal failure (ARF) and compared to those of 7 patients without renal disturbance. For a period of 7 days, a fixed dose of 2 g/day was given by a 15 min infusion. Pharmacokinetic parameters were calculated by fitting all serum and urine data measured over the period of treatment. Ceftriaxone free fraction was measured on days 2 and 7. There was no evidence for an intraindividual change in ceftriaxone-clearance during the observation period. Ceftriaxone renal clearance was closely dependent on creatinine clearance according to a linear regression expressed by Clren=0.14 Clcrea+2.2 (r=0.951,p〈0.0001). Total clearance was also associated with creatinine clearance: Cltot=0.19 Clcrea+8.2 (r=0.964,p〈0.0001). Related to the free fraction, renal clearance was in the range of the glomerular filtration rate. Non-renal clearance was strongly decreased when related to the free fraction indicating that biliary excretion is also impaired in patients with acute renal failure. Obviously no compensatory increase in hepatic ceftriaxone clearance takes place. It is concluded that elimination of ceftriaxone may be strongly impaired during acute renal failure in surgical intensive care patients and that dosage should be restricted according to degree of the impairment of creatinine clearance.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 39-45 
    ISSN: 1435-2451
    Keywords: Bile duct cancer ; Tumor resection ; Palliative therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Therapie des Gallengangscarcinoms wird unter dem Eindruck der endoskopischen Behandlungsmöglichkeiten teilweise kontrovers diskutiert. Wenngleich ein Vergleich zwischen den Patienten die chirurgisch und denen die endoskopisch bzw. radiologisch interventionell behandelt wurden aufgrund der unterschiedlichen Zusammensetzung der verschiedenen Patientenkollektive nicht möglich ist, zeigen doch retrospektive Arbeiten, daß ein wesentlicher Unterschied in der 30-Tage-Letalität nicht besteht. Kontrollierte oder gar randomisierte Studien liegen allerdings zu dieser Frage und zur Problematik der Lebensqualität nicht vor. Bisherige retrospektive Arbeiten zeigen jedoch, daß die nichtchirurgischen Verfahren mit einer höheren Spätkomplikationsrate als die chirurgischen Methoden belastet sind. Fortgeschrittene Tumorstadien lassen jedoch nur bei jedem dritten Patienten, im eigenen Krankengut sogar nur bei jedem zehnten Patienten eine Tumorresektion zu, so daß die endoskopische und chirurgische Therapie nicht als konkurrierende sondern sich ergänzende Methoden anzusehen sind.
    Notes: Summary The therapy of bile duct cancer is in some cases under controversial discussion. A retrospective comparison between patients who unterwent surgery or endoscopic treatment is difficult because of patient selection. It seems that there is no difference in the two groups with regard to 30 days mortality. A prospective or randomized study about this point of discussion is not available. Some retrospective studies show that patients with non-operative treatment had more late complications than had operated patients. Because of tumor extension resection is only possible in a few patients. Operation and endoscopic treatment are therefore not contradictary methods.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...