ISSN:
0009-2940
Keywords:
Hofman 1,6-elimination / Pyrazine derivatives / [2.2]Pyrazinophanes
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The title compounds 1-3 and their methyl derivatives 4-7 were synthesized 2,11-dithia[3.3]pyrazinophanes 24-26 or by Hofmann 1,6-elimination of the appropriate [(5-methyl-2-pyrazinyl)methyl]trimethylammonium hydroxides followed by dimerization of the generated 2,5-dihydro-2,5-dimethylenepyrazines. α-Chlorination of the methylpyrazines 8-10 with N-chlorosuccinimide gave the required precursors 11, 12, 14, 17 and 18. The results of the X-ray structure determinations for 1-4 and 7 which indicate an unequivocal isomer assignment are discussed with regard to steric strain in these molecules. The electronic spectra of the pyrazinophanes 7-7 are reported and compared with those of the parent methylpyrazines.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19901230319
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