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  • 1
    Electronic Resource
    Electronic Resource
    Engineering subtilisin for reaction in dimethylformamide (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 683-684 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00002a051
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  • 2
    Electronic Resource
    Electronic Resource
    Fragmentation of gold projectiles: From evaporation to total disassembly (1991)
    Springer
    The European physical journal 340 (1991), S. 263-270 
    Details
    ISSN: 1434-601X
    Keywords: 25.40.Sc ; 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have studied the fragmentation of Au projectiles interacting with targets of C, Al and Cu at an incident energy ofE/A=600 MeV. The employed inverse kinematics allowed a nearly complete detection of projectile fragments with chargeZ≧2. The recorded fragmentation events were sorted according to three observables, the multiplicityM lp of light charged particles, the largest atomic numberZ max within an event, and a new observable,Z bound, representing the sum of the atomic numbersZ of all fragments withZ≧2. Using these observables, the impact parameter dependence of the fragmentation process was investigated. For all three targets, a maximum mean multiplicity of 3 to 4 intermediate mass fragments (IMFs) is observed. The corresponding impact parameters range from central collisions for theC target to increasingly peripheral collisions for the heavier targets. It is found that the correlation between the IMF multiplicity andZ bound, extending from evaporation type processes (largeZ bound) to the total disassembly of the projectile (smallZ bound), is independent of the target nucleus. This universal behaviour may suggest an — at least partial — equilibration of the projectile fragment prior to its decay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294674
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  • 3
    Electronic Resource
    Electronic Resource
    Direct evidence that radiation induced micronuclei of early embryos require a mitosis for expression (1991)
    Springer
    Radiation and environmental biophysics 30 (1991), S. 117-122 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The naturally synchronous development of early mouse embryos was exploited to address the question, whether micronuclei require a mitosis for expression or whether they can be expressed in the same cell cycle, in which exposure to X-rays or caffeine took place. Experiments with 2-cell and with 4-cell embryos showed that micronuclei are expressed only if a mitosis is completed. There was no indication, even after doses up to 20 Gy, that micronuclei can be expressed before the mitosis was reached, which followed exposure. Furthermore, no nuclear fragmentation pointing to apoptosis could be detected in the cycle, in which cells were exposed. The same results were obtained when caffeine (5 mM) was used as micronucleus inducing agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219345
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes (1991)
    Springer
    Psychopharmacology 104 (1991), S. 45-50 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Carbamazepine ; Guanylate cyclase ; Lymphocytes ; Mechanism of action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorders is still unknown. The data presented here clearly indicate that therapeutic concentrations of both drugs inhibit sodium nitroprusside-induced accumulation of cGMP in human lymphocytes to about the same extent. The effect is not seen for other antidepressants, and shows pronounced interindividual variations in healthy volunteers. A similar effect of lithium and carbamazepine can also be demonstrated for the cGMP accumulation of central neurons using the model of dissociated cells of the mouse brain. The results are discussed in view of a common mechanism of action of both drugs. Furthermore, it is speculated that the individual sensitivity of the cGMP generating system of human lymphocytes to both drugs might be used to predict therapeutic response or nonresponse of the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244552
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The influence of head position on the intracranial pressure in preterm infants with posthemorrhagic hydrocephalus (1991)
    Springer
    Child's nervous system 7 (1991), S. 85-87 
    Details
    ISSN: 1433-0350
    Keywords: Intracranial pressure ; Posthemorrhagic hydrocephalus ; Head position
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to measure the intracranial pressure (ICP) of 8 newborn with posthemorrhagic hydrocephalus (group A) we used the noninvasive technique via the anterior fontanel (Ladd monitor). The ICP was monitored in two different head positions (30° elevated, horizontal). The median measurements were: elevated head position, 13 mm Hg, horizontal head position, 16 mm Hg. For comparative reasons, we also measured the ICP of 12 healthy newborns (group B). The median results were: elevated head position, 4 mm Hg, horizontal head position, 6.5 mm Hg. Significant differences were found between groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247862
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  • 6
    Electronic Resource
    Electronic Resource
    Levoprotiline ((−)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes (1991)
    Springer
    Journal of neural transmission 84 (1991), S. 141-146 
    Details
    ISSN: 1435-1463
    Keywords: Levoprotiline ; inositol phosphate generation ; human lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the atypical antidepressant levoprotiline (LPT) on inositol phosphate metabolism were investigated in N-formyl-methionyl-leucylphenylalanine (fMLP) activated human lymphocytes. In the presence of LPT, stimulation of phosphoinositide hydrolysis by fMLP lead to an increased accumulation of inositol bisphosphates, an effect which could be detected within the range of therapeutic plasma concentrations and which is exerted by lithium in a similar way. Furthermore, incubation of lymphocytes with LPT and subsequent stimulation with fMLP lead to a pronounced decrease in the level of free intracellular [3H]inositol. Both LPT effects, the increased accumulation of inositol bisphosphates and the reduction of free intracellular [3H]inositol, were found to be more pronounced for LPT than for its enantiomer (+)-oxaprotiline. The results are discussed in view of a possible biochemical mechanism which may contribute to the antidepressive activity of LPT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249118
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  • 7
    Electronic Resource
    Electronic Resource
    An identical epitope inPneumocystis carinii andToxoplasma gondii causing serological cross reactions (1991)
    Springer
    Parasitology research 77 (1991), S. 351-352 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A monoclonal antibody raised against membrane proteins ofToxoplasma gondii with molecular weights of 35 and 21 kDa also reacts strongly and “specifically” with surface antigens ofPneumocystis carinii with molecular weights of 394.2 and 69 kDa when used in a direct immunofluorescence antibody test, on the one hand, and in a immunoblot after sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), on the other. Whether or not this observation might have any phylogenetic relevance remains open.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00930914
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  • 8
    Electronic Resource
    Electronic Resource
    Dissolution of platinum metal alloys contained in the feed clarification sludge (1991)
    Springer
    Journal of radioanalytical and nuclear chemistry 152 (1991), S. 199-206 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The dissolution behaviour of two alloys, which represent the metallic precipitates, occurring in the dissolution step of a nuclear reprocessing plant was investigated. The solubility of these alloys, containing Mo, Ru, Rh and Pd, in HNO3-solutions is rather low and dissolution ceases after some time, caused by passivation. A significant acceleration of the dissolution rate takes place if ozone is passed through the alloy/HNO3-suspension, or if an electrolytic dissolver with or without an oxidation catalyst is used. Moreover, Ru can be separated as RuO4 by distillation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02042153
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  • 9
    Electronic Resource
    Electronic Resource
    On the influence of elastic mismatch on stress intensity factors of cracks perpendicular to a bimaterial interface (1991)
    Springer
    International journal of fracture 51 (1991), S. R21 
    Details
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00045814
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