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  • 1990-1994  (5)
  • 1991  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 639 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 14 (1991), S. 201-217 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 1196-1198 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 418 (1991), S. 204-213 
    ISSN: 1432-2013
    Keywords: Cl Channel ; Vascular smooth muscle cells ; DIDS ; SITS ; Zn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of Cl channel blockers on large-conductance (LC-type) Cl channels of cultured vascular smooth muscle cells (VSMC) were studied in order to characterize the channel pharmacologically. Intracellular disulphonic stilbene derivatives, such as 4,4′-diisothiocyanostilbene-2,2′-disulphonic acid (DIDS) and 4-acetamido-4-isothiocyanostilbene-2,2′-disulphonic acid (SITS) inhibited Cl channel activity in a dose-dependent manner. An obvious inhibitory effect of DIDS in this condition was obtained at concentrations higher than 5 μM, and the complete inhibition was obtained at around 100 μM, which was almost 10 times less than the effective dose of SITS. The inhibitory effect of DIDS was reversible at a drug concentration of lower than 50 μM. Single-channel conductance decreased as the concentration of DIDS increased. This decrease in the conductance was a consequence of unresolved openings of the channel due to fast blocking and unblocking rates of the drug. The Cl channel was also obviously inhibited by extracellular DIDS at a concentration of 1 mM. In addition, in cell-attached patches, 500 μM DIDS applied extracellularly inhibited Cl channel activated by the application of polymyxin B. We also investigated the effect of Zn on Cl channels in VSMC. Intracellular Zn dose dependently and reversibly blocked the channel at the positive intracellular potential range, whereas at the negative intracellular potential range it did not block the channel activity. Results in this study suggest the diversity of Cl channels among various tissues.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 29 (1991), S. 40-47 
    ISSN: 1741-0444
    Keywords: Laser Doppler flowmetry ; Local temperature provocation ; Photoplethysmography ; Probe geometry ; Skin blood perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Photoplethysmography (PPG) and laser Doppler flowmetry (LDF) were compared and evaluated. The comparison was accomplished considering differences in physical principles and geometrical and optical conditions. Changes in human skin perfusion were induced by cold and hot water provocation on limited areas of the finger and the forearm. The results showed that LDF and PPG, using red light at 630–660 nm and a commercial PPG probe, were in general equally sensitive in detecting a blood perfusion increase following a skin temperature elevation. However, we also found that PPG occasionally showed an inverse response to a skin temperature elevation, especially in finger skin. Furthermore, the study indicated that laser light is unsuitable as a light source in PPG using optical fibres of small diameter and with no fibre separation. It was also found that the physical dimensions of the probe (including the light source and photodetector) play an important role in determining the measuring volume and the quality of the signal.
    Type of Medium: Electronic Resource
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