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  • 1995-1999
  • 1990-1994  (4)
  • 1992  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Alumina ceramic prostheses for bone tumor surgery (1992)
    Springer
    Archives of orthopaedic and trauma surgery 112 (1992), S. 1-4 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1979 and 1990 reconstruction using a ceramic prosthesis with a polycrystal alumina segment and a monocrystal alumina stem was carried out in 65 patients after the resection of malignant or benign aggressive bone tumors. Resection of 18 osteosarcomas, 5 chondrosarcomas, 9 other sarcomas, 10 giant cell tumors, 20 metastatic bone tumors, and 3 other bone tumors was followed by replacement of 17 proximal femurs, 12 distal femurs, 12 proximal tibia, 11 proximal humeri, 3 distal radii, 5 midshafts of the long bone, 2 pelvises, and 3 other parts. Results were rated excellent in 4 cases, good in 43, fair in 13, and poor in 4. In the cases with benignly aggressive or low-grade malignant tumors and those with tumors of the proximal femur, proximal tibia, or midshaft, satisfactory results can be obtained. Four skin ulcers, three dislocations, three loosenings, two infections, and two breaks were noted. Close interfacing between the ceramic prosthesis and the bone was observed radiologically in all cases with cementless fixation except in cases with high-grade malignancies in the knee joint. These results demonstrate that the ceramic prosthesis can be beneficial for the management of patients with benignly aggressive or low-grade malignant bone tumors who have retained adequate muscle strength around the joint even after tumor resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431035
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine (1992)
    Springer
    Cell & tissue research 269 (1992), S. 213-220 
    Details
    ISSN: 1432-0878
    Keywords: Paneth cells ; Ultrastructure ; Morphometry ; Bethanechol ; Fluoride ion ; G-protein ; Mouse (Balb/c)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Paneth cells located at the bottom of intestinal crypts may play a role in controlling the bacterial milieu of the intestine. Using morphometry to clarify the secretory mechanism of the Paneth cells, we studied the ultrastructural changes in mouse Paneth cells produced following intra-arterial perfusion with Hanks' balanced salt solution containing a cholinergic muscarinic secretagogue (bethanechol), a neuroblocking agent (tetrodotoxin), or a G-protein activator (NAF/AlCl3). Bethanechol (2×10-4 mol/l) induced Paneth-cell secretion. Many Paneth cells massively exocytosed their secretory material into the crypt lumen; the enhanced secretion caused degranulation and vacuole formation. However, tetrodotoxin (2×10-6 mol/l) did not prevent the bethanechol-enhanced secretion by the Paneth cells. NaF (1×10-2 mol/l) and AlCl3 (1×10-5 mol/l) induced massive exocytosis of the Paneth cells; the exocytotic figures were similar to those observed in mice stimulated by bethanechol. G-protein activation was followed by a sequence of intracellular events, resulting in exocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319611
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of reactive oxygen intermediate scavengers on the antitoxoplasmic activity of activated macrophages (1992)
    Springer
    Parasitology research 78 (1992), S. 28-31 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Obioactin, Lonomycin A, muramyl dipeptide, and scavengers of hydrogen radicals and of singlet oxygen were used to study the participation of ·OH and1O2 in the killing ofToxoplasma in cultures of glycogen-induced peritoneal macrophages. Both the scavengers of OH (diazabicyclooctane and histidine) and those of1O2 (mannitol and sodium benzoate) failed to inhibit the multiplication ofToxoplasma in macrophages that were incubated with either Obioactin, Lonomycin A, or MDP. The results of these experiments demonstrate the apparent lack of an inhibitory effect of ·OH and1O2 on the multiplication ofToxoplasma, whereas the scavengers alone inhibited the growth of the parasites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00936177
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Personal computer system for ECG ST-segment recognition based on neural networks (1992)
    Springer
    Medical & biological engineering & computing 30 (1992), S. 2-8 
    Details
    ISSN: 1741-0444
    Keywords: Adaptive resonance theory ; Electrocardiogram ; Neural networks ; Personal computer ; ST-segment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A personal computer system for electrocardiogram (ECG) ST-segment recognition is developed based on neural networks. The system consists of a preprocessor, neural networks and a recogniser. The adaptive resonance theory (ART) is employed to implement the neural networks in the system, which self-organise in response to the input ECG. Competitive and co-operative interaction among neurons in the neural networks makes the system robust to noise. The preprocessor detects the R points and divides the ECG into cardiac cycles. Each cardiac cycle is fed into the neural networks. The neural networks then address the approximate locations of the J point and the onset of the T-wave (Ton). The recogniser determines the respective ranges in which the J and Ton points lie, based on the locations addressed. Within those ranges, the recogniser finds the exact locations of the J and Ton points either by a change in the sign of the slope of the ECG, a zero slope or a significant change in the slope. The ST-segment is thus recognised as the portion of the ECG between the J and Ton points. Finally, the appropriateness of the length of the ST-segment is evaluated by an evaluation rule. As the process goes on, the neural networks self-organise and learn the characteristics of the ECG patterns which vary with each patient. The experiment indicates that the system recognises ST-segments with an average of 95·7 per cent accuracy within a 15 ms error and with an average of 90·8 per cent accuracy within a 10 ms error, and that characteristics of the ECG patterns are stored in the long term memory of the neural networks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446186
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    Paper (German National Licenses)
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