ISSN:
1435-1463
Keywords:
L-threo-DOPS
;
freezing of gait
;
norepinephrine
;
dopamine
;
cerebrospinal fluid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We studied the effects of L-threo-DOPS (L-DOPS) on the concentrations of total (conjugated and unconjugated) dopamine (DA) and norepinephrine (NE) in the cerebrospinal fluid (CSF) of parkinsonian patients with freezing phenomenon. The NE concentration increased remarkably and dose-dependently after administration of L-DOPS in both L-dopa/carbidopa-pretreated and untreated patients. The DA concentration also increased mildly but significantly in L-dopa/carbidopa-untreated patients. Freezing phenomenon improved in 6 out of 8 patients at Hoehn and Yahr's stage III, and 1 out of 5 patients at stage IV. These results indicate that L-DOPS administration increases the NE concentration dosedependently, and is effective for freezing of gait of moderate severity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02260912
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