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Degradation mechanism of AlGaAs/GaAs laser diodes grown on Si substrates (1995)

Egawa, T. ; Hasegawa, Y. ; Jimbo, T. ; [et al.]

Woodbury, NY : American Institute of Physics (AIP)

Applied Physics Letters 67 (1995), S. 2995-2997

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ISSN: 1077-3118

Source: AIP Digital Archive

Topics: Physics

Notes: We have studied the rapid degradation of the AlGaAs/GaAs single quantum well laser diodes on Si substrates grown by metalorganic chemical vapor deposition. The dislocations propagate at velocities up to ∼75 μm/h along 〈100〉 and ∼20 μm/h along 〈110〉, which cause an increase in threshold current and a decrease in differential quantum efficiency. The degraded current–voltage characteristic resulted from the defect-assisted impurity diffusion. The degradation process occurs very rapidly due to the presence of a high density of defects and thermally induced strain. © 1995 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.114930

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Retroviral transfer of HSV1-TK gene into human lung cancer cell line (1995)

Hasegawa, Y. ; Emi, N. ; Shimokata, K.

Springer

Journal of molecular medicine 73 (1995), S. 107-112

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ISSN: 1432-1440

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We used a recombinant retrovirus as one of the potential vectors for human gene therapy to transfer a drug sensitivity gene into human lung cancer cells. The gene encoding the thymidine kinase (TK) of herpes simplex virus type 1 (HSV1) was used as the drug sensitivity gene. The antiherpes drugs acyclovir (ACV) and ganciclovir (GCV) were chosen to test the HSV1-TK activity transferred into the human lung cancer cell lines. The rationale for this approach was that ACV and GCV are nucleoside analogs specifically converted by HSV1-TK to a toxic form capable of inhibiting DNA synthesis or disrupting cellular DNA replication. The results obtained from our experiments demonstrate that the retroviral vector-mediated HSV1-TK gene transfer leads to ACV- and GCV-dependent cytotoxicity in human lung cancer cell lines, including both small-cell carcinoma and nonsmall-cell carcinoma. Although the gene transfer of HSV1-TK gene into tumor cells would be one model for gene therapy to control lung cancer, further investigations are necessary for the proper choice of the therapeutic gene and vector targeting such as tumor cell specific delivery of the gene or tumor cell specific expression of the transduced gene.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00198237

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A computer simulation study of normal and abnormal hip joint contact pressure (1995)

Genda, E. ; Konishi, N. ; Hasegawa, Y. ; [et al.]

Springer

Archives of orthopaedic and trauma surgery 114 (1995), S. 202-206

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ISSN: 1434-3916

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The contact pressure on 112 normal hip joints and 66 acetabular dysplastic hip joints was analysed using a three-dimensional rigid body spring model. Geometric models were made from conventional anteroposterior radiographs, with the assumption that the acetabular surface was spherical. In normal hips, the distribution of contact pressure was almost even over the joint surface, and the maximum contact pressure was relatively low. However, in a dysplastic hip joint, the pressure was concentrated on the anterolateral edge of the acetabulum and increased enormously not only with the reduction in lateral coverage but also with the reduction in the anterior coverage of the acetabulum. This result indicates that a three-dimensional analysis is indispensable for estimating the mechanical effect on acetabular cartilage.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00444263

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Long-term results of intertrochanteric varus osteotomy for arthrosis of the dysplastic hip (over 10 years' follow-up) (1995)

Iwase, T. ; Hasegawa, Y. ; Kataoka, Y. ; [et al.]

Springer

Archives of orthopaedic and trauma surgery 114 (1995), S. 243-247

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ISSN: 1434-3916

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We performed a retrospective clinical and radiographic review of the long-term results of 64 hips in 53 patients who underwent intertrochanteric varus osteotomy for arthrosis of the hip at the pre- or early stage with acetabular dysplasia. Their average age at operation was 26 years. The average duration of follow-up was 18 years and 10 months. The mean Harris hip score was 77 ± 9 points pre-operatively, and improved significantly to 84 ±13 points at the final follow-up. The acetabular coverage influenced the final outcome, and the postoperative prognosis was predictable from the acetabular head index (AHI) on a pre-operatively done hip maximum abduction radiograph (abd XP). We conclude that varus osteotomy for a dysplastic hip should be considered when the acetabular coverage is sufficient, and that a good prognosis can be expected when AHI on abd XP is greater than 60%.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00452079

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Treatment of advanced hormone-refractory prostate carcinoma with a combination of etoposide, pirarubicin and cisplatin (1995)

Naito, S. ; Ueda, T. ; Kotoh, S. ; [et al.]

Springer

Cancer chemotherapy and pharmacology 35 (1995), S. 225-229

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ISSN: 1432-0843

Keywords: Prostate cancer ; Hormone-refractory prostate carcinoma ; EAP regimen

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A total of 20 patients with hormone-refractory prostate carcinoma entered a pilot study of combination chemotherapy based on the EAP (etoposide, Adriamycin and cisplatin) regimen, in which Adriamycin was replaced by pirarubicin, a less cardiotoxic derivative of Adriamycin. The response was assessed by criteria modified from those of the National Prostatic Cancer Project: prostate-specific antigen was employed instead of acid phosphatase. Of 18 evaluable patients, 6 achieved a partial response, 5 had stable disease, and in 7 the disease had progressed during therapy; thus, the overall response rate was 33.3% [95% confidence interval (CI) 11.5–55.1%]. Significant pain alleviation and performance status improvement were obtained in 5 of 12 patients (41.7%; CI 13.8–69.6%) and 3 of 13 patients (23.1%; CI 0.2–46.0%), respectively. Although myelosuppression was moderate to severe, no chemotherapy-related deaths or bacteriologically documented sepsis occurred; nor was there any clinical cardiotoxicity. All the responding patients received maintenance chemotherapy with etoposide thereafter. At present, the median duration of response is 33 weeks (range: 23–91 weeks) and the median survival period for all patients is 42 weeks (range: 27+ −136 weeks), with 12 deaths. In spite of the small number of patients treated, these results suggest that this chemotherapy regimen is active in advanced hormone-refractory prostate carcinoma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00686552

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