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  • 1
    Electronic Resource
    Electronic Resource
    Safety and effect of transforming growth factor-β2 for treatment of venous stasis ulcers (1995)
    Oxford, UK : Blackwell Science
    Wound repair and regeneration 3 (1995), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Transforming growth factor-β2 promotes healing in a variety of animal models and exhibits clinical effects thought to be mediated by connective tissue formation. Two clinical trials were conducted to evaluate the safety and effect of transforming growth factor-β2 purified from bovine bone and delivered topically to venous stasis ulcers three times per week for up to 6 weeks by means of a lyophilized collagen vehicle. The first was an open-label trial comparing transforming growth factor-β2 purified from bovine bone (0.5 µg/cm2) with a placebo consisting of lyophilized collagen vehicle-without active drug. After no safety issues arose in that trial, a prospectively randomized, closed-label, observer-blinded, three-armed trial was conducted to compare bovine transforming growth factor-β2 (2.5 µg/cm2) with the collagen matrix placebo vehicle and with a standard dressing. Standardized elastic compression was applied to all test extremities. The rate of reduction of ulcer area as measured by planimetry was the primary measure of effect. No serious safety-related events occurred in either trial. Clinical evaluation suggested that improvement in the quality and quantity of granulation tissue appeared to precede epithelialization of ulcers treated with bovine transforming growth factor-β2. In both studies, treatment with bovine transforming growth factor-β2 appeared to have a positive effect on the rate of ulcer closure, whereas ulcers in the control groups continued to exhibit impaired healing. In the open-label study, the mean rate of closure of ulcers treated with bovine transforming growth factor-β2 was significantly greater than that of ulcers treated with placebo. There was likewise enhanced reduction in ulcer area in the ulcers treated with bovine transforming growth factor-β2 in the second trial. However, because of a higher variability in patient response and a greater placebo effect, the difference was not significant. The placebo was not worse than the standard care arm, thereby showing that the vehicle is not injurious to healing. The combined results of the two trials suggest that, at doses of 0.5 to 2.5 µg/cm2, bovine transforming growth factor-β2 is safe as a topically applied agent in a collagen matrix vehicle and can have a positive effect on closure of venous stasis ulcers. Large multicenter trials appear to be indicated to evaluate fully the potential utility of transforming growth factor-β2 in accelerating closure of chronic dermal ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-475X.1995.30207.x
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  • 2
    Electronic Resource
    Electronic Resource
    HLA-G deletion polymorphism and pre-eclampsia/eclampsia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.Design A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.Setting Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.Subjects One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.Results Genotypic and gene frequencies were not significantly different in the seven groups examined.Conclusion There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb11427.x
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  • 3
    Electronic Resource
    Electronic Resource
    A comparison of organ transplant patient and professional staff attitudes (1995)
    Springer
    International journal of rehabilitation and health 1 (1995), S. 167-178 
    Details
    ISSN: 1573-1537
    Keywords: organ transplantation ; patient-staff attitudes ; psychosocial selection criteria ; mutual role expectations ; communication style
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although most health care professionals acknowledge the importance of collaboration and team work between patients and staff in organ transplantation (TX), there is a scarcity of research exploring the nature of staff-patient relationships. We surveyed 204 TX-patients and professional staff (n=83 patients,n=121 staff) and compared their attitudes with regard to (a) psychosocial selection criteria of patients being assessed for organ TX, (b) patient and staff role expectations, and (c) communication styles in relation to organ TX. Our findings indicate overall agreement between patients and staff with regard to the importance of (a) family and social support, (b) current alcohol and drug abuse, and (c) patient noncompliance as factors to consider in the selection of candidates for TX. Attitudes and beliefs did not relate to demographic factors, years of experience (staff), or type of TX (patients and staff). Patients had higher expectations of nursing care and of shared patient-nurse roles than did staff (p〈0.001). Assessment of communication style found that collaboration was the least used style, while avoidance of communication and accommodation were the most common. Nurses, social workers, and chaplains were more willing to compromise than were patients and physicians (p〈0.001). We conclude that for TX patients and staff (a) there is general agreement with regard to the psychosocial criteria that are important in the selection of patients for organ TX; (b) post-TX misunderstandings may occur due to conflicting opinions about role responsibility, with patients (and physicians) having significantly stronger beliefs in the “equality” of role relationships than did other staff; and (c) resolution of problems is not collaborative in nature, or is unlikely to result in compromise, but instead is either a passive avoidance or an accommodation to satisfy others. These aspects of patient-staff relationships require further attention if TX programs are to obtain optimal results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02214729
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  • 4
    Electronic Resource
    Electronic Resource
    Mathematical model of self-cycling fermentation (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 46 (1995), S. 180-183 
    Details
    ISSN: 0006-3592
    Keywords: self-cycling fermentation ; mathematical model ; synchronous growth ; computer-controlled fermentation ; fermentation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article presents a mathematical model for biomass, limiting substrate, and dissolved oxygen concentrations during stable operation of self-cycling fermentation (SCF). Laboratory experiments using the bacterium Acinetobacter calcoaceticus RAG-1 and ethanol as the limiting substrate were performed to validate the model. A computer simulation developed from the model successfully matched experimental SCF intracycle trends and end-of-cycle results and, most importantly, settled into an unimposed periodicity characteristic of stable SCF operation. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260460212
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  • 5
    Electronic Resource
    Electronic Resource
    Thermolysis of polystyrene (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 58 (1995), S. 843-851 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Styrene was recovered from polystyrene (molecular weight of 138,000) by thermolysis in a nitrogen atmosphere at temperatures between 368 and 407°C. The results were independent of the initial weight of polystyrene, which was varied between 30 and 480 g. Up to 90% of the polystyrene was converted to liquid products. The liquid products had a styrene concentration as high as 90% and the styrene yield increased with temperature. Above 390°C, the residue left in the reactor (less than 30% of initial polystyrene charge) consisted mainly of styrene monomer, dimer, and trimer (MW of 190). The kinetics support a first-order reaction with regard to the rate of production of volatiles. The activation energy was estimated to be 166.5 kJ/mol. © 1995 John Wiley & Sons, Inc.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070580501
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