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  • 1995-1999  (5)
  • 1945-1949
  • 1930-1934
  • 1995  (5)
  • 1
    Electronic Resource
    Electronic Resource
    High resolution observations of pellet emission on TFTR (abstract)a) : Proceedings of the tenth topical conference on high temperature plasma diagnostics (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 841-841 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: High resolution, rapidly sampled measurements of the light emission from injected impurity pellets have recently been carried out on TFTR. Both wide and narrow views of the pellet light have been accomplished with a tightly collimated fanned array of fiber-optically coupled photomultipliers. Deep (≈100%), high frequency (40–90 kHz) modulation of the pellet emission has been observed in both neutral beam and rf heated discharges with as little as ≈1.5 MW of heating. This finding is consistent with recent work carried out on ASDEXb) with the exception that this modulation phenomenon is seen not only with hydrogenic pellets but also with lithium and boron pellets. This observation seems to point to an instability associated with the plasma surrounding the pellet rather than an instability which depends upon the atomic physics of the pellet. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146243
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Repression of lipopolysaccharide biosynthesis in Escherichia coli by an antisense RNA of Acetobacter methanolicus phage Acm1 (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 15 (1995), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Lysogenic Acetobacter methanolicus strains carrying the prophage Acm1 were found to be unable to synthesize both the capsutar polysaccharide (CPS) and the O-specific side-chain of lipopolysaccharide (LPS) and to represent rough variants of the host bacterium. A 262 bp DNA fragment of phage Acm1, obviously required for interference with LPS biosynthesis, was cloned and expressed in Escherichia coli Independently of the O-type, transformation of various E. coli strains with the recombinant DNA resulted in a suppression of biosynthesis of the O-specific chains. The DNA fragment of phage Acm1 contained three very short open reading frames of 21, 24, and 36 bp. However, attempts to express phage-encoded peptides were not successful. Instead, the Acm1-derived DNA fragment was shown to code for the synthesis of a trans-acting RNA molecule of 97 nucleotides, designated lbi (LPS biosynthesis-interfering) RNA. This RNA contains sequence complementarity to E. coli target RNA sequences and appears to have the ability to form intracellularly RNA hybrid duplexes with mRNA. The data presented in this study support the hypothesis that the phenotypic effect of conversion to rough-type LPS is accompanied by the expression of an antisense RNA of phage Acm1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1995.tb02285.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Db receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: Key words 5-Hydroxytryptamine (5-HT ; serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unambiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibition of cyclic AMP formation. 5-HT and the 5-HT1D receptor agonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effect of 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβ receptor mRNA in HUVEC. They support the involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Dβ receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: 5-Hydroxytryptamine (5-HT, serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unamiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibitiion of cyclic AMP formatin. 5-HT and the 5-HT1D receptor agaonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effct pf 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβreceptor mRNA in HUVEC. They support he involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Operator weighing in a multigrid method for locally refined grids (1995)
    Springer
    Journal of engineering mathematics 29 (1995), S. 473-496 
    Details
    ISSN: 1573-2703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Technology
    Notes: Abstract A multigrid method for an elliptic linear boundary value problem is presented. A consistent lowest-order mixed-finite-element discretisation is used on Cartesian locally refined grids in up to three space dimensions. The solution of the indefinite system of equations is reformulated as a problem of constrained minimisation. The constraint is satisfied exactly after one multigrid cycle; the functional is reduced iteratively by smoothing and coarse-grid corrections. By a suitable choice of prolongation and restriction operators, all corrections on coarser levels also reduce the functional within the constraint. This approach leads to a non-standard convergence proof which also holds for the variable-coefficient case. The proof does not predict the actual convergence rate, but shows that the functional will never increase after a multigrid cycle, while the constraint is satisfied exactly after the first multigrid cycle. The conditions required for convergence allow some freedom in choosing the restriction and prolongation operators, which can be used to improve the convergence rate. This leads to operator weighed restriction and prolongation operators in a novel manner. Some numerical examples are presented to demonstrate the robustness of the method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00043979
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    Paper (German National Licenses)
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