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  • 1
    Electronic Resource
    Electronic Resource
    Acyclovir-resistant chronic cutaneous herpes simplex in Wiskott-Aldrich syndrome (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 28-year-old man with Wiskott—Aldrich syndrome presonied with ulcerative-proliferative lesions on his face from which herpes simplex type 1 (HSV-1) was isolated. He was initially treated with 10 mg/kg of acyclovir (Zovirax®) intravenously every 8h, but his skin lesions worsened. Clinical resistance to acyclovir was suspected, and therapy with this drug was intensified. The dosage of acyclovir was increased to 45 mg/kg, administered by continuous infusion, and the lesions subsequently resolved. The strain of HSV recovered from the patient showed acyclovir-resistance in vitro, using the colorimetric method with neutral red.Herpes simplex virus resistance to acyclovir is rare. It is more common in immunocompromised patients if subtherapeutic doses are administered in the treatment of chronic persistent forms of infection. Whenever clinical resistance to acyclovir is suspected, the dosage should be increased to 2 mg/kg per h administered via an infusion pump. If no improvement is observed in the patient's condition with this regimen, a phosphorylated medication whose mechanism of action is not dependent on viral thymidine kinase, such as foscarnet (phosphonoformic acid), should be substituted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02682.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for normal and inhomogeneous lowermost mantle and core-mantle boundary structure under the Arctic and northern Canada (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 122 (1995), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Seismic P waves from a total of about 200 nuclear explosions in the USA, the former USSR and China, observed at 10 arrays and four networks in Europe, Canada and the USA, are used to analyse the structure at the base of the mantle and the core-mantle boundary (CMB).The simple waveforms and well-controlled source parameters of nuclear explosions allow one to use the events as source arrays in addition to the usual receiver array configuration. A new array technique (double beamforming; Krüger et al. 1993) integrating both concepts is applied, which increases the slowness resolution considerably.A total of 56 source-receiver combinations (i.e. reflection points in the lower mantle or on the CMB) could be analysed. In five regions, anomalous arrivals (PdP) with slowness and arrival times between those of P and PcP are observed. One of these five areas (Svalbard region) shows short-period PcP/P amplitude ratios, which are about three times higher than those predicted by standard earth models. In the Severnaya Zemlya region, where PdP and PcP precursors were observed previously (Krüger et al. 1993), PcP shows azimuth deviations of up to 10°. For some other regions, deviations of the PcP waveform from the direct P waveform are also observed.These anomalous phases and the PcP waveform distortions cannot be explained with standard 1-D earth models. They are probably produced by inhomogeneities in the lowermost mantle. The observed variations in the waveforms are strong indications of a laterally heterogeneous structure in two depth ranges. The first is the CMB and its immediate vicinity of a few tens of kilometres; the second region is the depth range between about 200 and 300 km above the CMB. Maps of the North Pole region, giving the distributions of inhomogeneities in the lower mantle and on the CMB, are presented. These maps show evidence of strong heterogeneity of the D″ boundary layer and possibly also of the CMB in the same area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1995.tb07017.x
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  • 3
    Electronic Resource
    Electronic Resource
    Securinine, an Alkaloid from Fluggea virosa (1995)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 127-129 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270194007857
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  • 4
    Electronic Resource
    Electronic Resource
    Improvement of the catalytic properties of penicillin G acylase from Escherichia coli ATCC 11105 by selection of a new substrate specificity (1995)
    Springer
    Applied microbiology and biotechnology 43 (1995), S. 679-684 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Cloned penicillin G acylase (PGA) from Escherichia coli ATCC 11105 was mutagenized in vivo using N–methyl-N′-nitro-N–nitrosoguanidine. Mutants of PGA were selected by their ability to allow growth of the host strain E. coli M8820 with the new substrates phenylacetyl-β-alanyl-L-proline (PhAc-βAla-Pro) phthalyl-L-leucine (Pht-Leu) or phthalylglycyl-L-proline (Pht-Gly-Pro) as sole source of proline and leucine respectively. PGA mutants were purified and immobilized onto spherical methacrylate (G-gel). The immobilized form of mutant PGA selected with (PhAc-βAla-Pro) hydrolyzed 95% of 9 mmol penicillin G 30% faster than wild-type PGA using the same specific activities. The specific activity of the soluble enzyme was 2.7-fold, and inhibition by phenylacetic acid was halved. Immobilized PGA mutant selected with Pht-Gly-Pro hydrolyzed penicillin G 20% faster than wild-type PGA. The K m of the soluble enzyme was increased 1.7-fold. Furthermore, the latter two mutants were also 3.6-fold more stable at 45°  C than wild-type PGA. The specific activity of the mutant selected with Pht-Leu was 6.3-fold lower, and inhibition by phenylacetic acid was increased 13-fold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164773
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  • 5
    Electronic Resource
    Electronic Resource
    Improvement of the catalytic properties of penicillin G acylase from Escherichia coli ATCC 11105 by selection of a new substrate specificity (1995)
    Springer
    Applied microbiology and biotechnology 43 (1995), S. 679-684 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Cloned penicillin G acylase (PGA) from Escherichia coli ATCC 11105 was mutagenized in vivo using N-methyl-N′-nitrosoguanidine. Mutants of PGA were selected by their ability to allow growth of the host strain E. coli M8820 with the new substrates phenylacetyl-β-alanyl-l-proline (PhAc-βAla-Pro) phthalyl-l-leucine (Pht-Leu) or phthalylglycyl-l-proline (Pht-Gly-Pro) as sole source of proline and leucine respectively. PGA mutants were purified and immobilized onto spherical methacrylate (G-gel). The immobilized form of mutant PGA selected with (PhAc-gbAla-Pro) hydrolyzed 95% of 9 mmol penicillin G 30% faster than wild-type PGA using the same specific activities. The specific activity of the soluble enzyme was 2.7-fold, and inhibition by phenylacetic acid was halved. Immobilized PGA mutant selected with Pht-Gly-Pro hydrolyzed penicillin G 20% faster than wild-type PGA. The K m of the soluble enzyme was increased 1.7-fold. Furthermore, the latter two mutants were also 3.6-fold more stable at 45° C than wild-type PGA. The specific activity of the mutant selected with Pht-Leu was 6.3-fold lower, and inhibition by phenylacetic acid was increased 13-fold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164773
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  • 6
    Electronic Resource
    Electronic Resource
    The Littoral Station of Aguda, in the North of Portugal (1995)
    Springer
    Helgoland marine research 49 (1995), S. 429-438 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The public authorities have recently approved the building of a Littoral Station in Aguda, a small fishing village on the Atlantic coast, 15 km south of the River Douro estuary in the municipal area of Vila Nova de Gaia. The internal structure of the building involves a Fishery Museum exhibiting ancient and modern gear, a Public Aquarium displaying the local marine fauna and flora and a Research and Educational Department for marine biology, aquaculture and fishery. The project was drawn up by the architect João Paulo Peixoto, in collaboration with local engineers, and the author. In Aguda there is an active, small-scale fishery, based on traditional methods handed down from generation to generation. The almost unstudied local marine fauna and flora is characterized by a high diversity of invertebrates and a rich abundance of fish stocks. Easy access to a variety of marine biotopes is guaranteed by means of the local fishing-fleet, thus supporting the Station's programme of education and research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02368369
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  • 7
    Electronic Resource
    Electronic Resource
    Theories for multiple resonances (1995)
    Springer
    The European physical journal 351 (1995), S. 391-396 
    Details
    ISSN: 1434-601X
    Keywords: 21.60.Jz ; 21.60.Ev ; 03.65.Sq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Two microscope theories for multiple resonances in nuclei are compared, n-particle-hole RPA and quantized Time-Dependent Hartree-Fock (TDHF). The Lipkin-Meshkov-Glick model is used as test case. We find that quantized TDHF is superior in many respects, except for very small systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291144
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  • 8
    Electronic Resource
    Electronic Resource
    Total charge-changing cross sections for neutron-deficient isotopes from58Ni fragmentation (1995)
    Springer
    The European physical journal 352 (1995), S. 69-75 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Ft ; 25.70.Np ; 27.40.+Z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract At the projectile-fragment separator FRS of GSI, relativistic secondary beams of about 520 MeV/nucleon were produced by fragmentation of a primary beam of58Ni at 650 MeV/nucleon in a beryllium target. By means of aΔE—Bρ—TOF measurement, the fragments have been identified and their charge-changing probabilities in targets of CH2, C, Al, and Pb have been determined. We describe the results for the total charge-changing cross sections in this first paper, whereas a second article deals with the partial charge-changing cross sections. At the drip line, the measured charge-changing cross sections exhaust close to 100% of the total interaction cross sections as calculated with semiempirical models. The measurements at the proton drip line with low-Z targets indicate that only a very small increase of the cross sections may be observed, whereas the measurements with a lead target show that no significant increase of the total charge-changing cross sections is present which would be a hint for low-lying dipole strength. Our experimental data are compared to Glauber-type calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292761
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  • 9
    Electronic Resource
    Electronic Resource
    Partial charge-changing cross sections for neutron-deficient isotopes from58Ni fragmentation (1995)
    Springer
    The European physical journal 352 (1995), S. 77-83 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Ft ; 25.70.Np ; 27.40.+z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract At the projectile-fragment separator FRS of GSI, relativistic secondary beams of about 520 MeV/nucleon were produced by fragmentation of a primary beam of58Ni at 650 MeV/nucleon in a beryllium target. By means of aΔE—Bρ—TOF measurement, the fragments were identified and their charge-changing probabilities in targets of (CH2) n , C, Al, and Pb placed at the exit of the FRS were determined. Whereas a first article dealt with the total charge-changing cross sections, we describe in this second article the element distributions of these secondary fragments, which are found to depend strongly on the isospin of the secondary projectile as well as on the target material. In the case of the lead target, the influence of the electromagnetic dissociation is clearly visible in the one-proton and two-proton removal channels. The preference for the formation of even-Z fragments is much more pronounced for exotic secondary projectiles than for projectiles close to stability. Calculations with a geometrical abrasion-ablation model allow to understand the global features of the experimental data. However, far from stability, the discrepancies between calculations and experimental data increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292762
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  • 10
    Electronic Resource
    Electronic Resource
    Early-onset septicemia in a newborn due to a penicillin resistant pneumococcus probably transmitted during delivery (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 68-69 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112625
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