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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract One of the open questions regarding the adaptive response to ionizing radiation is whether it can be induced in G0 lymphocytes. In the majority of experiments in which an adaptive response in G0 lymphocytes was observed, the adapting dose was applied in vivo. In order to investigate whether there is some in vivo component of adaptive response, mouse splenocytes of the C57BL/6 strain were irradiated with 0.1 Gy x-rays either in vivo or in vitro, and their UV-light-induced unscheduled DNA synthesis (UDS) levels were determined autoradiographically. An augmented UV-light-induced UDS following an adapting dose applied in vivo has previously been described by several authors in splenocytes of C57BL/6 mice, indicating that the adapting dose enhanced the DNA repair capacity of lymphocytes. In the present investigation, however, no evidence of an adaptive response could be seen regardless of whether the adapting dose was given in vivo or in vitro. Those results present a further indication for the fact that the adaptive response to ionizing radiation is not always inducible, even in lymphocytes of an inbred mouse strain in which its existence has been reported before.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Continuum mechanics and thermodynamics 7 (1995), S. 199-218 
    ISSN: 1432-0959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A method is presented which allows to compute the stress intensity factors (SIFs) of a ceramic roller bearing ring with a surface flaw. First, the stresses due to mechanical loads applied to the surfaces of the undamaged ring are computed, using Michell's expression for Airy's stress function in polar coordinates ([l]). Second, the stress intensity factors of the flaw are obtained using Tada's additivity principle ([2]), namely by integration of the point force solution for the SIF of a surface crack with the aforementioned stresses as input parameter. To illustrate the procedure, the special case of a ring with a surface flaw which is loaded by six equidistantly spaced cylindrical rollers will be studied numerically.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Continuum mechanics and thermodynamics 7 (1995), S. 199-218 
    ISSN: 1432-0959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A method is presented which allows to compute the stress intensity factors (SIFs) of a ceramic roller bearing ring with a surface flaw. First, the stresses due to mechanical loads applied to the surfaces of the undamaged ring are computed, using Mitchell's expression for Airy's stress function in polar coordinates ([1]). Second, the stress intensity factors of the flaw are obtained using Tada's activity principle ([2]), namely by integration of the point force solution for the SIF of a surface crack with the aforementioned stresses as input parameter. To illustrate the procedure, the special case of a ring with a surface flaw which is loaded by six equidistantly spaced cylindrical rollers will be studied numerically.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of polymers and the environment 3 (1995), S. 133-143 
    ISSN: 1572-8900
    Keywords: BOD respirometer ; anaerobic biodegradation ; poly(β-hydroxybutyrate) ; poly(ε-caprolactone) ; Bioceta ; Mater-Bi ; aquarium test system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents a test scheme for assessing the biodegradation potential of polymers, starting with aquatic screening systems (aerobic and anaerobic) and continuing to long-term systems. At the end of the scheme the material has to prove its behavior under the relevant disposal conditions. Aerobic screening was performed mainly under aquatic conditions, but also in soil, using BOD-respirometry. Carbon balances were performed to obtain a better evaluation of the biodegradation potential. Under anaerobic conditions, biodegradation in an aquatic medium was followed by measuring CH4 and CO2 production. Polymers not fully degraded in the screening systems were tested in aquarium systems for at least 1 year. Biodegradation was followed by monitoring the DOC released in the water, mass loss, and microbial growth on the samples and in the water as well as via FTIR spectroscopy and SEM pictures. Results are presented for the polymers PHB, PHBV, PCL, Mater-Bi AI05H and ZF03U, and Bioceta. By combining the data from the screening with the aquarium system, a good picture of the degradation behavior of the polymers is obtained.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-601X
    Keywords: 25.75.+r ; 25.85.-w ; 27.90.+b
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Electromagnetic fission of238U projectiles at E/A =600 and 1000 MeV was studied with the ALADIN spectrometer at the heavy-ion synchrotron SIS. Seven different targets (Be, C, Al, Cu, In, Au and U) were used. By considering only those fission events where the two charges added up to 92, most of the nuclear interactions were excluded. The nuclear contributions to the measured fission cross sections were determined by extrapolating from beryllium to the heavier targets with the concept of factorization. The obtained cross sections for electromagnetic fission are well reproduced by extended Weizsäcker-Williams calculations which include E1 and E2 excitations. The asymmetry of the fission fragments' charge distribution gives evidence for the excitation of the double giant-dipole resonance in uranium.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-160X
    Keywords: Early rheumatoid arthritis ; IgA-alpha-1-antitrypsin complex ; Radiological deterioration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We followed the levels of serum IgA-alpha-1-antitrypsin (IgA-AT) complex in 37 patients with early rheumatoid arthritis (RA) during the first 3 years of the disease. The changes in IgA-AT were correlated with a radiological damage score (DS) of the hands assessed according to Larsen. At the onset of the disease, the IgA-AT serum concentration was significantly higher as compared to the control group (0.72±0.22 U vs 0.29±0.14 U, P〈0.01). The level significantly decreased during the 3-year observation period. The DS was significantly higher after 3 years. However, this difference was due to changes in only 11 patients; in 26 patients the DS was almost unchanged. In the group of 11 patients with radiological progression, the level of IgA-AT either remained high or increased significantly (0.95±0.18 U at the onset, 0.97±0.25 U after 3 years), whereas we observed a decrease in IgA-AT in 26 patients without radiological progression (0.63±0.16 U at the onset of the disease, 0.45±0.10 U after 3 years, P〈0.01). Moreover, a relationship between changes in IgA-AT serum level and radiological progression was shown (r=0.60, P〈0.01). Our studies suggested that the relationship between IgA-AT level and radiological progression of the disease should be considered. We cannot exclude the possibility that the constant high level of IgA-AT may cause worsening in bone erosions.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2013
    Keywords: Voltage-sensitive dyes ; Ventricular myocytes ; Field stimulation ; Whole-cell clamp ; Optical micromapping ; Optical potential monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An especially designed setup which consists of an inverted fluorescence microscope, an argon ion laser and a photodiode array system permits membrane potential monitoring in isolated guinea-pig ventricular cardiomyocytes, stained with the voltage-sensitive dye di-4-ANEPPS, which responds linearly with relative fluorescence changes (ΔF/F) ≈ −8% per 100 mV. About a dozen measuring spots covering a single cell were simultaneously monitored with a spatial and temporal resolution of 15 μm and about 20 μs, respectively. In general, the rising phases of the action potentials within a single cell were highly synchronized (i.e. all upstroke velocities peaked within about 20 μs); however, in one cell (out of 25 examined) significant (P 〈 0.05) time lags exceeding the signal-dependent time resolution were also found. Experiments, simultaneously performed with our optical system and a widely used patch-clamp setup, revealed a slowed and delayed response of the clamp amplifier depending on the cell access resistance. Optical monitoring during whole-cell voltage-clamping demonstrated the influence of graduated series resistance compensation. When field stimulation was used, our results clearly demonstrated the spatially dependent polarization of the cell membrane during the stimulus, as well as a highly synchronized upstroke development. Slight differences in the maximum upstroke velocities within a single cell were also found and were basically in agreement with mathematical models.
    Type of Medium: Electronic Resource
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