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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 20 (1997), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— This paper presents the results of an experimental testing programme to examine the uniaxial creep, low cycle fatigue and creep/fatigue interaction behaviour of a Ni-base superalloy at 700°C. The material is used in the manufacture of aeroengine turbine discs. A creep continuum damage mechanics model is shown to be capable of accurately predicting the creep and creep rupture behaviour of the material. A healing term has been incorporated into the damage mechanics model to allow the behaviour under creep/fatigue conditions to be described.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In a randomized study, prevention of goiter recurrence with l-thyroxine was compared with pure iodide substitution after thyroid surgery for nodular goiter in an iodine-deficient area. Altogether 107 patients were followed up for 52 weeks after thyroid resection. The thyroid volume was determined sonographically. Free thyroxine, total thyroxine, thyrotropin, thyroglobulin, and antibodies to thyroglobulin and thyroid peroxidase were measured. The thyroid volume decreased slightly over the course of a year in the two therapy groups. There was no significant difference between the two groups. Recurrences were seen with both l-thyroxine medication and iodide substitution. The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group. Antibody formation was not observed under iodine substitution. In an area of iodine deficiency, substitution with iodide is just as effective as medicating the patients with l-thyroxine for preventing recurrences.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1617-4623
    Keywords: Key words Regulation of gene expression  ;  Rhizobium meliloti  ;  Exopolysaccharide biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Rhizobium meliloti MucR protein is known to regulate the biosynthesis of the two exopolysaccharides, succinoglycan and galactoglucan. The mucR gene was successfully overexpressed in Escherichia coli BL21 cells by heat shock induction using a two-plasmid system. Cell extracts of the production strain contained about 20% of a polypeptide of 17 kDa apparent molecular mass, corresponding to the size expected for MucR. As shown by an electrophoretic mobility shift assay, these extracts were active in the specific retardation of a 219-bp DNA fragment including 134-bp of the non-coding region upstream of the mucR gene. Primer extension analysis showed that this DNA fragment was located within the transcribed region upstream of the mucR gene. Competition experiments revealed that a 44-bp sequence present within the 134-bp upstream of the mucR gene contained the MucR binding site. Although binding of MucR to this site exhibited a moderate dissociation constant of $K_{\rm d} \approx 1.4 \times10^{-7}$ M, the reaction was highly specific since fragments containing binding sites for the homologous Ros protein from Agrobacterium tumefaciens were not able to compete for MucR binding.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0563
    Keywords: Key words Impotence • Veins • Penile venous surgery • Penile erection ; Schlüsselwörter Impotenz • Penile Venenchirurgie • Prognosefaktoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den letzten Jahren wurde vermehrt über schlechtere Langzeiterfolge der Penisvenenchirurgie bei venösem Leck berichtet. Dies veranlaßte uns, unser Patientenkollektiv von 126 Patienten, die zwischen 1987 und 1996 einer dorsalen Penisvenenligatur unterzogen wurden, im Rahmen einer erneuten klinischen Visite oder durch ein standardisiertes Telefoninterview bzw. einen Fragebogen im Langzeit-Follow-up zu evaluieren. Den klinischen Ausgang teilten wir in folgende 3 Gruppen ein: volle spontane Erektion, postoperatives Ansprechen auf Schwellkörperautoinjektionstherapie (SKAT) und keine Veränderung der Erektionsfähigkeit postoperativ. Der Kurzzeiterfolg nach 1–3 Monaten betrug auf diese Gruppen bezogen 31 (24,6 %), 25 (19,8 %) und 70 (55,6 %) Patienten. Nach einer Langzeitbeobachtung von 6–76 Monaten (Mittelwert 33 ± 19,6) verschlechterten sich diese Werte auf 14 (11,2 %), 24 (19 %) und 88 (69,8 %) Patienten. Eine erneute Verschlechterung eines anfänglichen Operationserfolges trat in 86 % der Fälle innerhalb des ersten postoperativen Jahres auf (p K 0,001). Als günstige Prognosefaktoren konnten wir ein präoperatives Bestehen der Erektionsstörung unter 7 Jahre, ein normales Corpus-cavernosum-Elektromyogramm (CC-EMG) und ein Maintenance-Flow unter 45 ml/min bestimmen. Waren alle drei Parameter gegeben, so stieg die Langzeiterfolgsrate (spontane Erektion plus SKAT-Responder) von 30 % im gesamten Patientengut auf 67 % bei diesem günstigen Patientenkollektiv (p K 0,001). Diese Studie zeigt, daß die Langzeiterfolge der DPVL bei nicht-selektionierten Patienten enttäuschend sind, eine Selektion der Patienten jedoch mit bestimmten Prognosefaktoren vorgenommen werden kann.
    Notes: Summary Poor longterm success has been reported for penile vein ligation the last few years. Therefore, we decided to re-investigate our group of 147 patients who were operated on between 1987 and 1996. All patients showed a negative response to intracavernous injection therapy at the time of diagnosis and revealed a maintenance flow 〉 15 ml/min, as well as a pathological venous flow with pharmacocavernosometry or pharmacocavernosography. These patients underwent ligation of all superficial dorsal veins and resection of the deep dorsal vein of the penis. An up-to-date record of the success of the operation was kept either by a renewed clinical visit or by a standardized telephone interview or questionnaire. A total of 126 patients were available here for long-term follow-up. We divided the findings into three groups: complete spontaneous erection, postoperative response to cavernous auto-injection therapy and no changes in erectile competency postoperatively. The short-term success rate for these groups after 1–3 months was an outcome of 31 (24.6 %), 25 (19.8 %) and 70 (55.6 %) patients; 86 % of the cases whose results deteriorated after the initial operation success rate had this happen within the first postoperative year (p K 0.001). Favorable prognostic factors were preoperative erectile dysfunction of K 7 years, a normal CC-EMG and a maintenance flow of K 45 ml/min. If all three parameters were present, the long-term success rate (spontaneous erection plus response to intracavernous injection) of 30 % of all patients was found to rise to 67 % in this selected group of patients (p K 0.001). This study reveals that long-term success for unselected patients undergoing penile venous surgery is disappointing; however, careful selection of patients by certain prognostic factors can improve long-term results.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Meteorology and atmospheric physics 62 (1997), S. 201-214 
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary The influence of turbulent friction on the propagation of cold fronts is investigated by numerical simulations using a two-dimensional mesoscale model. We compare the frictional effect with the effects of large-scale shear forcing and energy conversion at the earth's surface and discuss the synergic effect of all three mentioned processes. There is no pure superposition of these effects indicating that nonlinear interaction plays a role. In addition it is possible to show that—depending on the along-front jet—friction does not necessarily slow down the front but can also accelerate it. The direction of the along-front jet within the planetary boundary layer (PBL) is crucial for that question.
    Type of Medium: Electronic Resource
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