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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 5 (1999), S. 598-606 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Traditionell werden neue therapeutische Konzepte in der Therapie von malignen Erkrankungen ausschließlich unter dem Aspekt der Sicherheit und klinischen Effizienz beurteilt. Erst in den letzten Jahren ist zu beobachten, daß zunehmend auch wirtschaftliche Fragestellungen systematisch untersucht werden. Unter diesem Aspekt ist die Hochdosischemotherapie (HDT) besonders interessant. Der Einsatz der HDT hat die Therapiemöglichkeiten bisher unheilbarer maligner und einiger benignen Erkrankungen erweitert, ihr medizinischer und ökonomischer Stellenwert ist bislang jedoch noch nicht ausreichend definiert.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Key words Fistula ; arteriovenous ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report our experience in using Guglielmi electrolytically detachable coils (GDC) alone or in combination with other materials in the treatment of intracranial or cervical high-flow fistulae. We treated 14 patients with arteriovenous fistulae on brain-supplying vessels – three involving the external carotid or the vertebral artery, five the cavernous sinus and six the dural sinuses – by endovascular occlusion using electrolytically detachable platinum coils. The fistula was caused by trauma in six cases. In one case Ehlers-Danlos syndrome was the underlying disease, and in the remaining seven cases no aetiology could be found. Fistulae of the external carotid and vertebral arteries and caroticocavernous fistulae were reached via the transarterial route, while in all dural fistulae a combined transarterial-transvenous approach was chosen. All fistulae were treated using electrolytically detachable coils. While small fistulae could be occluded with electrolytically detachable coils alone, large fistulae were treated by using coils to build a stable basket for other types of coil or balloons. In 11 of the 14 patients, endovascular treatment resulted in complete occlusion of the fistula; in the remaining three occlusion was subtotal. Symptoms and signs were completely abolished by this treatment in 12 patients and reduced in 2. On clinical and neuroradiological follow-up (mean 16 months) no reappearance of symptoms was recorded.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-6079
    Keywords: PACS: 31.15.Ar Ab initio calculations – 31.15.Qg Molecular dynamics and other numerical methods – 31.50.+w Excited states – 31.70.Hq Time-dependent phenomena: excitation and relaxation processes and reaction rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We present the outline of the ab–initio molecular dynamics method for adiabatic excited states which is suitable to treat the involved excited electronic states simultaneously with the motion of the nuclei. The method allows the simulation of time–resolved pump–probe signals and the analysis of the signals in terms of the underlying nuclear dynamics. Moreover, the timescales of the structural relaxation in excited electronic states vs. intramolecular vibrational relaxation processes can be estimated and the influence of the initial temperature of the cluster can be determined. The method is applied to the analysis of the timescales as well as of the dynamics of localized/delocalized electronic excitations in the Na2F molecule which represents a test example for nonstoichiometric alkali–halides with one excess electron. The aim is to develop a method for the investigation of time–dependent laser induced processes in clusters which is capable to extract the leading physical effects responsible for the controlled excitation dynamics and for the evolution of the non–equilibrium states.
    Type of Medium: Electronic Resource
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