ISSN:
1432-1912
Keywords:
Phentolamine
;
Isoprenaline
;
Uptake-Blockers
;
Renin-Angiotensin System
;
Drinking
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The increase in water intake, plasma concentration of renin (PRC) and angiotensin I (PAC) induced in rats by the α-sympatholytic agent phentolamine (2.0 mg/kg) is potentiated by the neuronal uptake-blockers cocaine (5.0 mg/kg), desipramine (8.0 mg/kg) and amitriptyline (7.5 mg/kg). The dipsogenic, PRC- and PAC raising activity of the β-mimetic drug isoprenaline (100 μg/kg) remained unaffected by the uptake-blockers used. These results confirm the hypothesis that the increase in PRC is caused by the stimulation of certain β-receptors, which are activated directly by the β-mimetic isoprenaline, while the α-lytic phentolamine does so by a reflex-mediated catecholamine release. These experiments further emphasize the importance of the renin-angiotensin system for the increase in water intake caused by isoprenaline and phentolamine in rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00499180
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