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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 95 (2005), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Synthesis and subsequent sequestration into vesicles are essential steps that precede neurotransmitter exocytosis, but neither the total neurotransmitter content nor the fraction sequestered into vesicles have been measured in individual live neurons. We use multiphoton microscopy to directly observe intracellular and intravesicular serotonin in the serotonergic neuronal cell line RN46A. We focus on how the relationship between synthesis and sequestration changes as synthesis is up-regulated by differentiation or down-regulated by chemical inhibition. Temperature-induced differentiation causes an increase of about 60% in the total serotonin content of individual cells, which goes up to about 10 fmol. However, the number of vesicles per cell increases by a factor of four and the proportion of serotonin sequestered inside the vesicles increases by a factor of five. When serotonin synthesis is inhibited in differentiated cells and the serotonin content goes down to the level present in undifferentiated cells, the sequestered proportion still remains at this high level. The total neurotransmitter content of a cell is, thus, an unreliable indicator of the sequestered amount.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 98 (1994), S. 5778-5783 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 54 (2005), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The international journal of advanced manufacturing technology 16 (2000), S. 370-375 
    ISSN: 1433-3015
    Keywords: Keywords: Die design optimisation; Hybrid intelligent system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Die design is heavily experience based and the die design process is an iterative procedure of trial and error in order to obtain a final die design for the successful manufacture of stampings. Most automotive industries use internal guidelines and past experience for die design. Even though powerful computer-aided design systems are being used in automotive industry, the lack of adequate analysis tools at the initial die geometry design stage hinders the die manufacturing process, and also necessitates lead times of the order of 5–30 weeks [1]. At the concept design stage, and during the initial die development process, the variations in geometry and process conditions are so large that it is prohibitively expensive to use 3D finite element analysis. The complexity of die design heuristic knowledge hinders the development and application of knowledge-based systems. Hybrid intelligent systems are computer programs in which at least one of the constituent models simulates intelligent behaviour [2]. These models could be knowledge-based systems, artificial neural networks, fuzzy logic systems, etc. In this approach both artificial neural networks, knowledge-based systems and finite-element analysis (FEA) for modelling the design process are used. A simulation-based design approach [3] for the die design process is followed. Artificial neural networks (ANNs) are preliminary design tools which indicate the formability of the component geometry, for the selected process and material conditions. The ANN module is trained from FEA results for a generic set of component geometries, process conditions, and material properties. The final die design validation is carried out by FEA. The intelligent frame-work incorporates rules for material selection, process parameter selection and their modification. Component geometry is a critical parameter which affects the manufacturability of the given part. Hence, an intelligent geometry handling module, which automatically modifies and optimises the geometry of the designed die, is implemented in the present system. Knowledge-based blackboard architecture is used for the integration of various analysis models such as CAD, FEA, and ANN, as an intelligent framework for die design [4]. The hybrid intelligent system provides an integrated decision support environment for simulation and analysis of the forming process, both during the initial die design phase and during the die tryout phase. The hybrid intelligent systems approach supports the capability for automatic evaluation of prospective die design for manufacturability, and performs automatic modification of design inputs. Applications of the hybrid intelligent system for die design are described together with a comparison with shop floor data.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 25 (2000), S. 358-375 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Various boundary element method (BEM) based approaches to solve crack problems are discussed. The displacement method, J-integral method and the modified crack closure integral (MCCI) method for the evaluation of the stress intensity factors (SIFs) are reviewed. Effects of partial and total modelling of singularities on the accuracy of the results have been presented. Elements capable of partial and total modelling of the wellknown square root singularities, variable order singularities, neighbouring variable order singularities, etc., are also reviewed. Case studies are included to illustrate the effectiveness of the various methods of calculation of the SIFs and the performance of the special elements.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 7 (1991), S. 329-339 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A formulation for incorporating two singular points (TSP) of variable orders in a single finite element is presented. Though the element does not satisfy any of the convergence criterion, its performance is found to be good, which has been demonstrated by considering number of examples on kinked cracks. In each case only one such element is incorporated in the whole discretization. These examples illustrate the usefulness of the element to analyse kinked cracks of various sizes and shapes and subjected to different loading and boundary conditions. Computed J-integrals are compared with analytical solutions, wherever possible, and the accuracy appears quite good. Effect of size of the element on, and the path independence of, J are also examined.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The international journal of advanced manufacturing technology 16 (2000), S. 376-381 
    ISSN: 1433-3015
    Keywords: Keywords: Artificial neural network; Springback; Vee air bending
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Springback is a serious problem in the air vee bending process because of its inconsistency. An on-line tool to control spring-back is more reliable than an analytical model which might not be able to control the stroke of the machine in real-time. Therefore, one might resort to adaptive control or use an artificial neural network (ANN) trainer, either using experimental data or analytical predictions (or both), and use it for real-time control of the machine tool. The inconsistency in springback is then reduced to within acceptable limits. Adaptive control would need several strokes to complete the job, but it is envisaged that the job could be completed in a single stroke with the ANN. The present paper discusses the development of an ANN which can be used to train and later to predict the springback, as well as the punch travel, to achieve the desired angle in a single stroke in an air vee bending process.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 268 (1990), S. 901-910 
    ISSN: 1435-1536
    Keywords: Copolyamides ; synthesis ; cross-linking ; thermal analysis ; thermaldegradation ; solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Some new flexible and cross-linkable copolyimides containing rubbery unsaturated aliphatic chain moiety (CPLA) were prepared by low temperature polycondensation betweenm-phenylene diamine,bis- 3(4 carboxy phthalimido) benzene, and liquidα,Ω bis [2-(4 piperazinyl) ethyl aminocarbonyl] poly-(butadiene-co-acrylonitrile) (ATBN) in (DMAC) solution. The effect of rubbery aliphatic moiety in these copolyimides on the polymer properties has been reported. A comparative study on the properties of these copolyimides (CPLA) with the mixture of ATBN and a low molecular-weight cross-linkable copolyimide possessing the same molecular structure as the aromatic moiety of CPLA polymers has been made.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 272 (1994), S. 1203-1207 
    ISSN: 1435-1536
    Keywords: Polyazoxyphosphonate ; XPS-L01 ; 31P-NMR ; Flame retardancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new polyazoxyphosphonate was synthesized by reaction of 4-4′-dihydroxyazoxybenzene and dichlorophenyl phospine oxide by interfacial polycondensation using a phase transfer catalyst. The polymer was characterized and the results obtained by various analytical techniques indicate that it is mostly amorphous, low molecular weight and soluble in organic solvents such as DMF, DMAC, NMP, etc. The high char residue (∼40%) and limiting oxygen index indicate flame retardancy of the polymer which is due to phosphorus. Thermal stability of this polymer is moderate. TheT g appears to be at 152°C.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 27 (1992), S. 4605-4613 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Tensile and impact properties of talc-filled isotactic polypropylene composites are investigated at 0–60 wt% filler contents. Tensile modulus registered an increase whereas tensile yield strength and strain-at-break decreased with increasing filler content. Mechanical restraint imposed by the talc particles on the molecular mobility or deformability of polypropylene explained the increase in modulus and decrease in strain-at-break while decrease in tensile yield strength was attributed to decreased crystallinity and formation of stress concentration points around the filler particles. Izod impact strength decreased with increased talc content. Surface modification of talc with a titanate coupling agent LICA 38 enhanced the filler-polymer interaction, further modifying the composite properties consequent upon significant decrease in the stress concentration. Scanning electron microscopic studies revealed better dispersion of surface-modified filler particles in the polymer matrix.
    Type of Medium: Electronic Resource
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