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  • 2005-2009  (2)
  • 2000-2004  (6)
  • 1985-1989  (2)
  • Prognostic factors  (4)
  • ddc:000
  • spillover through the gas phase
  • 1
    Electronic Resource
    Electronic Resource
    Verlaufsbeobachtungen bei HIV-infizierten homosexuellen Männern mit Lymphadenopathiesyndrom (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 864-872 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Lymphadenopathy ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 26 homosexual men with antibodies to HIV and generalized lymphadenopathy were examined between 1982 and 1984. Lymphadenopathy was accompanied by clinical symptoms such as fever, diarrhoea and weight loss (50%), moderate leukopenia (15%), lymphocytosis (50%), hypoergy to intraepidermal skin test with recall-antigens (12%), elevated serum levels of IgG (62%), IgA (23%), IgM (19%), beta-2-microglobulin (76%) and neopterin (69%), diminished absolute numbers of CD4-helper cells in the peripheral blood (24%) and an inversion of the ratio CD4-helper cells/CD8-suppressor cells both in blood (64%) and in lymphnodes (36%). Mitogen induced lymphocyte proliferation was significantly lower and the serum levels of gamma-interferon were significantly higher than in healthy controls. Lymphnode biopsy revealed only nonspecific reactive hyperplasia with follicular hyperplasia in 54%, a mixed pattern of both follicular hyperplasia and follicular involution with paracortical expansion in 25% and follicular involution with paracortical expansion in 21%. 22 patients were followed longitudinally for a median time of 37 months (33–51 months). 10 patients (46%) developed fullblown AIDS within a median period of 35 months (24–46 months) after first examination and 43 months (36–77 months) after the anamnestic onset of the lymphadenopathy syndrome. The parameters distinguishing these patients from those without progression of disease were higher serum levels of gamma-interferon, higher relative and absolute numbers of CD8-suppressor cells in the peripheral blood, a reduced number of CD4-helper cells in the lymphnodes, and a lower CD4/CD8 ratio as well in the peripheral blood as in the lymphnodes. Despite of the significant differences, these parameters varied in a wide range. Therefore, we could not establish a symptom likely to predict the emergence of AIDS in an individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737007
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Manifestation von AIDS in HIV-infizierten homosexuellen Männern mit Lymphadenopathie-Syndrom (LAS) (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 936-939 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Lymphadenopathy ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 26 homosexual men with HIV-infection and lymphadenopathy syndrome were examined between 1982 and 1984 and prospectivelly observed over a period of 58 months (median, range 53–69 months). 16 (61.5%) developed full blown AIDS within a median period of 41 months (23–63 months). 12 of them died 50 months (median, range 29–67 months) after the first examination. 10 patients showed no symptoms of AIDS after a median observation time of 57 months (54–63 months). A panel of clinical symptoms, signs of concomitant infections, chemical and immunological analyses, including a lymphnode biopsy were correlated to the course of the disease. A decreased proportion of CD4-cells and a lower CD4/CD8ratio in the lymphnode suspensions at the first examination in patients with disease progression were the only parameter which correlated significantly with the development of AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721419
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pathomorphological and Histological Prognostic Factors in Curatively Resected Ductal Adenocarcinoma of the Pancreas (2000)
    Springer
    Surgery today 30 (2000), S. 582-587 
    Details
    ISSN: 1436-2813
    Keywords: Key Words Ductal pancreatic carcinoma ; Curative resection ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fate of patients with potentially resectable carcinomas is not only determined by the pTNM tumor stage, but also possibly by tumor-biological factors. The aim of this study was to identify these prognostic factors in patients undergoing primary curative (R0) resection. The study retrospectively analyzed 113 patients with ductal adenocarcinoma who were operated on between 1986 and 1995. R0 resection was able to be performed in 93 patients. Lymph node metastases were found in 73%. The rates of lymph vessel and perineural invasion were 83.5% and 45%, respectively. Among the 25 carcinomas without lymph node metastases, 64% already had lymph vessel invasion and 48% had perineural invasion. The cumulative 5-year survival rate of the 91 surviving patients analyzed was 10.5%. Depending on the tumor stage we found a significant difference in 5-year survival rates between patients without lymph node metastases (26.5%) and those with lymph node involvement (5%) (P = 0.008). A multivariate analysis only identified lymph vessel invasion (L0/1), tumor size (≦/≦2 cm), and tumor grading (G) to have significant and independent prognostic value. Lymph vessel invasion, tumor size, and tumor grading proved to be independent factors determining long-term prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070096
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Prognostic factors in the operative treatment of ductal pancreatic carcinoma (2000)
    Springer
    Langenbeck's archives of surgery 385 (2000), S. 14-20 
    Details
    ISSN: 1435-2451
    Keywords: Key words Ductal pancreatic carcinoma ; Prognostic factors ; Surgical treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background and aims: The average 5-year survival rate following resection of a ductal adenocarcinoma of the pancreas is 10%, worldwide. Despite increasing resection rates, only about 20% can be operated on with curative intent. A differential histopathological analysis of the resected tumors may help to justify expanding the surgical procedure by extended lymph-node dissection. Patients/methods: Between January 1986 and December 1995, a total of 113 patients underwent resection with curative intent for a ductal pancreatic carcinoma with regional lymph-node dissection. All histological findings were reviewed and reclassified in accordance with the 1997 Union Internationale Contra la Cancrum (UICC) classification. Survival data for all of these patients were obtained from family doctors and registration offices. Independent prognostic factors were statistically analyzed. Results: Of the 113 patients, 93 received an R0 resection. The postoperative mortality rate was 2.2% (2 of 93). More than one-half of the tumors had a diameter of between 2.1 cm and 4 cm. Among the 22 tumors measuring up to 2 cm in diameter, 41% already had lymph-node metastasis and 86% invasion of the lymphatic vessels. Carcinomas measuring between 4.1 cm and 6 cm were all associated with lymph-vessel invasion. Perineural invasion was present in 50% of the tumors. A noteworthy finding was the fact that 64% of the 25 tumors with negative lymph nodes had lymph-vessel invasion, and 48% perineural invasion. The cumulative 5-year survival rate of the R0-resected patients was 10.5%. Patients with lymph-node-negative stages survived significantly longer (26.5%) than patients with lymph-node-positive stages (5%). Furthermore, a significant difference was seen between pN1a and pN1b (16.7% vs 2.2%). Multivariate analysis identified tumor grading, tumor size and lymph vessel invasion as independent prognostic factors. Conclusions: Apart from the factors tumor size and tumor grading, lymph-vessel invasion appears to be of special significance for the long-term prognosis. Already in the pN0 stage, the latter was present in 64% of the cases and must be considered a precursor of lymphogenic metastasization. Since lymph-vessel invasion was demonstrated in 86% of tumors measuring less than 2 cm, the therapeutic consequence for all ductal pancreatic tumors is an extended lymphatic and soft tissue dissection that goes beyond the regional lymph-node stations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050004
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Indirect Catalysis, Caused by Hydrogen Spillover Through the Gas Phase. Activation by Hydrogen Oxygen Reaction (2000)
    Springer
    Reaction kinetics and catalysis letters 71 (2000), S. 335-341 
    Details
    ISSN: 1588-2837
    Keywords: Indirect catalysis ; spillover through the gas phase ; hydrogen spillover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Earlier investigations revealed that glass surfaces may get catalytic properties by hydrogen spillover. Occasional activations by oxyhydrogen reaction, observed there, were executed systematically now and revealed high and stable degrees of activity of glass activated in this way. The activation energies for the hydrogenation of cyclohexene on the glass 'catalyst' are 18.1 kJ mol-1 (T 〉 367 K) 33.6 kJ mol-1 (T 〉 367 K)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010339512972
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  • 6
    Electronic Resource
    Electronic Resource
    Hydrogen Spillover Through the Gas Phase. Some Kinetic Aspects (2000)
    Springer
    Reaction kinetics and catalysis letters 71 (2000), S. 325-333 
    Details
    ISSN: 1588-2837
    Keywords: Hydrogen spillover ; spillover through the gas phase ; indirect catalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The deactivation kinetics of spillover hydrogen in the gas phase was investigated by systematic variation of the distance between catalyst and reaction compartment. It turned out to be a first-order reaction. Glass surfaces strongly accelerate the deactivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010387428902
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  • 7
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    Unknown
    Density functional study of guanine and uracil quartets and of guanine quartet metal/ion complexes (2000)
    Details
    Publication Date: 2014-02-26
    Description: The structures and interaction energies of guanine and uracil quartets have been determined by B3LYP hybrid density functional calculations. The total interaction energy $\Delta$E$^{T}$ of the $\it{C}$$_{4h}$-symmetric guanine quartet consisting of Hoogsteen type base pairs with two hydrogen bonds between two neighbour bases is -66.07 kcal/mol at the highest level. The uracil quartet with C6-H6...O4 interactions between the individual bases has only a small interaction energy of -20.92 kcal/mol and the interaction energy of -24.63 kcal/mol for the alternative structure with N3-H3...O4 hydrogen bonds is only slightly more negative. Cooperative effects contribute between 10 and 25 \% to all interaction energies. Complexes of metal ions with G-quartets can be classified into different structure types. The one with Ca$^{2+}$ in the central cavity adopts a $\it{C}$$_{4h}$-symmetric structure with coplanar bases, whereas the energies of the planar and non-planar Na$^{+}$ complexes are almost identical. The small ions Li$^{+}$, Be$^{2+}$, Cu$^{+}$ and Zn$^{2+}$ prefer a non-planar $\it{S}$$_{4}$-symmetric structure. The lack of co-planarity prevents probably a stacking of these base quartets. The central cavity is too small for K$^{+}$ ions and therefore this ion favours in contrast to all other investigated ions a $\it{C}$$_{4}$-symmetric complex, which is 4.73 kcal/mol more stable than the $\it{C}$$_{4h}$-symmetric one. The distance 1.665 {\AA} between K$^{+}$ and the root mean squares plane of the guanine bases is approximately half of the distance between two stacked G-quartets. The total interaction energy of alkaline earth ion complexes exceeds the ones with alkali ions. Within both groups of ions the interaction energy decreases with an increasing row position in the periodic table. The B3LYP and BLYP methods lead to similar structures and energies. Both methods are suitable for hydrogen-bonded biological systems. Compared with the before mentioned methods the HCTH functional leads to longer hydrogen bonds and different relative energies for two U-quartets. Finally we calculated also structures and relative energies with the MMFF94 forcefield. Contrary to all DFT methods, MMFF94 predicts bifurcated C-H...O contacts in the uracil quartet. In the G-quartet the MMFF94 hydrogen bond distances N2-H22...N7 are shorter than the DFT distances, whereas the N1-H1...O6 distances are longer.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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    OPUS
  • 8
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    Computer-aided design of novel siderophores: Pyridinochelin (2000)
    Details
    Publication Date: 2014-02-26
    Description: Pyridinochelin, a novel catecholate type siderophore, has been designed on the basis of the active analog enterobactin. Growth promotion tests indicate that this synthetic siderophore feeds various pathogenic bacteria effectively with iron even though it lacks one catecholate group compared to enterobactin. The superposition of the siderophore structures suggests that the structure of the skeleton connecting the catecholate groups might be an important factor for the iron transport.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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  • 9
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    Unknown
    ZIBgridfree - Adaptive Conformation Analysis with qualified Support of Transition States and Thermodynamic Weights (2005)
    Details
    Publication Date: 2014-02-26
    Description: This paper introduces a new algorithm of conformational analysis based on mesh-free methods as described in [M. Weber. Mehless methods in Conformation Dynamics.(2005)]. The adaptive decomposition of the conformational space by softly limiting functions avoids trapping effects and allows adaptive refinement strategies. These properties of the algorithm makes ZIBgridfree particularly suitable for the complete exploration of high-dimensional conformational space. The adaptive control of the algorithm benefits from the tight integration of molecular simulation and conformational analysis. An emphasized part of the analysis is the Robust Perron Cluster Analysis (PCCA+) based on the work of Peter Deuflhard and Marcus Weber. PCCA+ supports an almost-characteristic cluster definition with an outstanding mapping of transition states. The outcome is expressed by the metastable sets of conformations, their thermodynamic weights and flexibility.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
    Format: application/pdf
    Format: text/plain
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    OPUS
  • 10
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    ConFlow? A new space-based Application for complete Conformational Analysis of Molecules (2006)
    Details
    Publication Date: 2014-02-26
    Description: Biochemical interactions are determined by the 3D-structure of the involved components - thus the identification of conformations is a key for many applications in rational drug design. {\sf ConFlow} is a new multilevel approach to conformational analysis with main focus on completeness in investigation of conformational space. In contrast to known conformational analysis, the starting point for design is a space-based description of conformational areas. A tight integration of sampling and analysis leads to an identification of conformational areas simultaneously during sampling. An incremental decomposition of high-dimensional conformational space is used to guide the analysis. A new concept for the description of conformations and their path connected components based on convex hulls and {\em Hypercubes}is developed. The first results of the {\sf ConFlow} application constitute a 'proof of concept' and are further more highly encouraging. In comparison to conventional industrial applications, {\sf ConFlow} achieves higher accuracy and a specified degree of completeness with comparable effort.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
    Format: application/pdf
    Format: application/postscript
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