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  • 1
    Electronic Resource
    Electronic Resource
    In vitro effect of Fansimef on human neutrophil and monocyte function (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 587-590 
    Details
    ISSN: 1432-1041
    Keywords: Fansimef ; phagocytosis ; malaria treatment ; neutrophil function ; monocyte function ; chemotaxis ; oxidative metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of Fansimef, a recently registered triple combination of mefloquine, sulfadoxine and pyrimethamine (10:25:1) on human peripheral blood polymorphonuclear and mononuclear leucocyte function was studied. At clinically obtainable concentrations Fansimef had no effect on leucocyte viability, it did inhibit neutrophil chemiluminescence and it had no effect on other major functions, such as chemotaxis, NBT reduction, superoxide production, phagocytosis and the bactericidal activity of phagocytic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635897
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Augmentation of human blood monocyte microbicidal activity by RU 41740, a glycoprotein extract fromKlebsiella pneumoniae (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 99-104 
    Details
    ISSN: 1432-1041
    Keywords: RU 41740 ; Candida albicans ; chemotaxis ; monocyte locomotion ; superoxide production ; candidacidal activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Non-specific activation of host defences may have a significant impact on the outcome of infections in the immunocompromized patient. RU 41740, a glycoprotein extract fromKlebsiella pneumoniae, effective in increasing resistance to experimental infections in animals, has been examined in vitro for its effect on human blood monocyte locomotion, phagocytosis, killing ofCandida albicans, and release of superoxide anion. RU 41740 had no chemo-attractant activity nor any effect on monocyte chemotactic and phagocytic function. Candidacidal capacity and superoxide anion production by monocytes were significantly enhanced after preincubation with RU 41740 〉1.0 µg/ml. The effect was dose- and time-dependent and was not influenced by the presence of lymphocytes or their culture supernatants. This suggests a direct interaction with monocytes as the mechanism of action of the extract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614204
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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