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  • 1
    Electronic Resource
    Electronic Resource
    Erythrodermia caused by allergy to codeine (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 52 (2005), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2005.0566c.x
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  • 2
    Electronic Resource
    Electronic Resource
    Intradermal testing of fixed drug eruption (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04505.x
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  • 3
    Electronic Resource
    Electronic Resource
    Prevalence of pollinosis in the Basque Country (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The prevalence of allergic diseases, mainly pollinosis, has increased within the last decades. Our study aimed to determine the prevalence of sensitization to Poaceae pollen in the Basque Country. This is a region of northern Spain, with an area of 7261 km2 and a population of 2109009 inhabitants. Two different climatic regions may be distinguished in the Basque Country (the Atlantic and the Oceanic). Methods: A transversal study was carried out on 2216 subjects, aged 10–40 years. A personal interview was carried out in order to compile study data, by means of a questionnaire that had been previously validated with a clinical history and an allergy study. Results and Conclusions: Our results show the prevalence of pollinosis in the Basque Country to be 10.6% (C.I. 95% 9.35–11.96%) without significant differences between men and women. The prevalence in the Atlantic climate area (9.71%) was lower than in the Oceanic climate area (13.61%). There were no differences between persons living in a rural environment (10.87%) and those living in an urban setting (10.51%). Pollinosis was more frequent in individuals aged 10–20 (11.41%) and 20–30 (12.54%) than those aged 30–40 years (7.43%). Three features significantly distinguished pollinic from nonpollinic patients:〈list xml:id="l1" style="custom"〉a more common complaint of symptoms after ingestion of Rosaceae fruits or nuts (10.2%)a family history of atopy (8.8%)a greater occurrence of bronchial asthmatic symptoms (23%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00146.x
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  • 4
    Electronic Resource
    Electronic Resource
    Pickled onion-induced asthma: a model of sulfite-sensitive asthma? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Asthma elicited by sulfite ingestion has been mainly described in steroid-dependent and in non-atopic asthmatics. We have studied a group of 18 young extrinsic asthmatics who presented with asthma attacks immediately after eating pickled onions.Objective: The aim of this study is to ascertain if these asthma attacks are elicited by sulfites contained in pickled onions and the influence of the dose and pH of onions.Methods: The bronchial hyperreactivity of the patients was assessed by a methacho-line challenge test. Oral challenge tests were performed with sodium metabisulfite (MBS) diluted in lemon juice at pH 4.2 and at pH 3.3 (only in patients who did not react with pH 4.2). Two types of pickled onion, Spanish and Dutch pickled onions, were used for oral challenge in seven of the patients. The Monier-Williams method was used to measure the SO2 concentration in pickled onions.Results: The oral provocation test with MBS, pH 4.2, elicited a positive response in six patients (33.3%) and the test at pH3.3 was positive in three out of 12. No significant difference in PD20 values was found between these groups. Three of the seven patients challenged with Spanish pickled onions had a positive reaction but had no reaction with Dutch pickled onions. The SC2 concentration in Spanish pickled onions varied between 765 and 1182 ppm while in Dutch pickled onions were 200 ppm; this exceeded the permitted level (100 ppm). SO2 release in Spanish pickled onion samples was nearly 2.5 times higher when the pH of the sample decreased from 4.2 to 3.3.Conclusion: High levels of SO2 in Spanish pickled onions, and their low pH (3.3) would be the responsible factors of the asthmatic outbreaks after ingestion of Spanish pickled onions by these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb00006.x
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  • 5
    Electronic Resource
    Electronic Resource
    Erythema-multiforme-like eruption from antibiotics of 3 different groups (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 34 (1996), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1996.tb02187.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Allergic contact dermatitis from a beeswax nipple-protective (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb02093.x
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  • 7
    Electronic Resource
    Electronic Resource
    Photodermatitis from plant derivatives in topical and oral medicaments (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 35 (1996), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1996.tb02347.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Anisakis simplex, a relevant etiologic factor in acute urticaria (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Del Pozo MD, Audícana M, Diez JM, Muñoz D, Ansotegui IJ, Fernández E, García M, Etxenagusia M, Moneo I, Fernández de Corres L. Anisakis simplex, a relevant etiologic factor in acute urticaria. Anisakis simplex, a parasite of fish and cephalopods, can induce IgE-mediated reactions. This study aimed to determine the etiologic role of A. simplex in patients affected by urlicaria/angioedema ‘AE’ or anaphylaxis. We studied 100 adult subjects suffering acute episodes of urticaria/AE, by anamnesis, prick tests with A. simplex and fish-mix extracts, and total and specific IgE to both A. simplex and cod. The following criteria of A. simplex allergy were considered: 1’ urticaria/AE within 6 h after fish ingestion; 2’ specific IgE to A. simplex; 3’ positive prick test to A. simplex extract; 4’ exclusion of other suspected causes. Double-blind, placebo-controlled food challenge was not carried out because ethical considerations forbid challenge with a parasite. Specific IgE to A. simplex‘〈0.7 kU/1’ was found in 22 subjects, but only eight were diagnosed as having A. simplex allergy. Other allergens were involved in 37 patients, and 55 cases were considered idiopathic. Specific IgE to fish ‘〈0.7 kU/1’ was found in two patients, but only one was diagnosed as having fish allergy. We concluded that A. simplex is an important etiologic factor in acute urticaria. We suggest that it should be considered in cases of urticaria/AE or anaphylaxis, especially after fish ingestion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1997.tb02603.x
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  • 9
    Electronic Resource
    Electronic Resource
    Age-related performance of human subjects on saccadic eye movement tasks (1998)
    Springer
    Experimental brain research 121 (1998), S. 391-400 
    Details
    ISSN: 1432-1106
    Keywords: Key words Saccade ; Visual fixation ; Anti-saccade ; Reaction times ; Express saccade ; Frontal cortex ; Aging ; Senescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We measured saccadic eye movements in 168 normal human subjects, ranging in age from 5 to 79 years, to determine age-related changes in saccadic task performance. Subjects were instructed to look either toward (pro-saccade task) or away from (anti-saccade task) an eccentric target under different conditions of fixation. We quantified the percentage of direction errors, the time to onset of the eye movement (saccadic reaction time: SRT), and the metrics and dynamics of the movement itself (amplitude, peak velocity, duration) for subjects in different age groups. Young children (5–8 years of age) had slow SRTs, great intra-subject variance in SRT, and the most direction errors in the anti-saccade task. Young adults (20–30 years of age) typically had the fastest SRTs and lowest intra-subject variance in SRT. Elderly subjects (60–79 years of age) had slower SRTs and longer duration saccades than other subject groups. These results demonstrate very strong age-related effects in subject performance, which may reflect different stages of normal development and degeneration in the nervous system. We attribute the dramatic improvement in performance in the anti-saccade task that occurs between the ages of 5–15 years to delayed maturation of the frontal lobes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050473
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  • 10
    Electronic Resource
    Electronic Resource
    Chromogranin A inhibits dopamine release from rat striatal slices (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 1083-1089 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Chromogranin A (CGA) ; striatal slices ; dopamine ; transmitter release ; calcium ; pancreastatin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Chromogranin A (CGA), a prohormone and a protein component of endocrine and neural secretory granules, neuritic plaques in Alzheimer's disease and Lewy bodies in Parkinson's disease, inhibited the release of dopamine (DA) from perfused rat striatal slices. Dopamine release was stimulated by a pulse of high potassium (40 mM) medium introduced at 20 minutes (K1) and 55 minutes (K2) following equilibration. The ratio of K2/K1 was 0.80 ± 0.04 in control tissues, but fell significantly to 0.26 ± 0.08 when 100 nM purified CGA was added prior to the second potassium pulse. This reduction in DA release was equivalent to that seen when calcium was excluded from the buffer (0.19 ± 0.05). Pancreastatin, a centrally active peptide product of CGA, had no effect on stimulated DA release (0.77 ± 0.06), although it, as well as the other treatments, did reduce basal DA release. It is likely that the parent molecule itself, CGA, or an as yet unidentified product is responsible for inhibition of K-stimulated striatal DA release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050113
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