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  • 1
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1939
    Keywords: Cation balance in plant ; Calcicoly/calcifugy ; K/Ca interactions ; Nutritional ecotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Dittrichia (ex Inula) viscosa is a ruderal species that has recently become an invading plant in the northwest Mediterranean basin. A previous study failed to demonstrate the occurrence of morphologically differentiated ecotypes among populations of the species but suggested the existence of nutritional ecotypes. This latter possibility is examined here by comparing the ability of plants from contrasting habitats to control cation accumulation balance. Dittrichia viscosa plants, from eight siliceous habitats and nine calcareous habitats of southern France and neighbouring Spain and Italy, were cloned and grown together hydroponically with a solution simulating an acid soil with an aluminium constraint. Two independent hydroponic units containing solution supplemented with two levels of Al were used (2 Al levels x17 populations x3 genotypes x3 replicates). The growth and cation content (K, Ca, Mg and Na) of plant shoots and the chemical composition of the soil of each habitat were analysed. At the high Al level (1.1mm), populations differed in K, Ca and Mg plant proportions. Two groups could be distinguished: one containing all but one siliceous populations and the other containing all but one calcareous populations. Plants of the siliceous group accumulated proportionally more K and less Ca, and had better growth, than plants of the calcareous group, in the same way as calcifuge and calcicole species when grown on acid soil. At the lowest Al level (0.37mm), differences between siliceous and calcareous populations were less marked. The results suggest that differences in the ability of plants to control K and Ca balance, which appear to be of adaptive significance, could have arisen through selection, and that Dittrichia viscosa has evolved calcifuge and calcicole nutritional ecotypes in siliceous and calcareous habitats respectively. Various degrees of calcifugy, and to a lesser extent of calcicoly, can thus be suggested to occur among the studied populations, some in relation to the intensity of mineral stress in the natural habitats. So far, only functional traits have provided evidence of ecotypic differentiations within Dittrichia viscosa.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Anti-Müllerian hormone (AMH) ; Müllerian-inhibiting substance (MIS) ; Intersex ; Male pseudohermaphroditism ; Uterus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The persistent Müllerian duct syndrome is characterized by the retention of Müllerian derivatives in patients otherwise normally virilized. Clinically, the persistence of uterus and tubes leads either to cryptorchidism or inguinal hernia, depending on whether or not the Müllerian derivatives can be mobilized during testicular descent. The condition is usually discovered at surgery, however preoperative sonography could allow the diagnosis to be made preoperatively. The molecular basis of the persistent Müllerian duct syndrome is heterogeneous, and is reflected by wide variations in the serum concentration of anti-Müllerian hormone. Some cases are apparently due to end-organ resistance, and are associated with normal serum levels of the hormone. Others, characterized by absent or low hormone concentrations, can be explained by mutations of the gene coding for anti-Müllerian hormone, which are distributed along the whole length of the coding region.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-4935
    Keywords: cystic fibrosis ; protein kinase C ; glycoconjugate secretion ; phorbol esters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20-3H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity (Kd=25.8 vs 12.8 nM respectively) but expressed a similar number of total phorbol ester binding sites (about 2.5 pmol PDBu bound/mg of protein); (2) exhibited a faster and higher response to 4β-phorbol 12β-myristate 13α-acetate (PMA) for the stimulation of [35S]-labelled glycoconjutate release, but were equally sensitive to the synergistic effect of A23187 on this process; and (3) secreted glycoconjugates with similar [35S]-sulfate and [14C]-leucine to [14C]-glucosamine labelling ratios. Taken together, these results provide further evidence for abnormal protein kinase C (PKC) regulation of macromolecule secretion in CF disease.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 3 (1969), S. 227-232 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé 1. Sept années de recherches sur le «Grand Récif» de Tuléar (côte sud-ouest de Madagascar) conduisent les auteurs à présenter quelques résultats préliminaires nouveaux et à suggérer quelques hypothèses de travail concernant notamment la structure trophique du complexe biocoenotique récifal. 2. Le «Grand Récif” de Tuléar paraît constituer un système presque autarcique doté d'une production primare benthique importante représentée par: les zooxanthelles, qui paraissent être éliminées normalement de façon plus ou moins rythmique par les invertébrés hôtes; les Diatomées et Cyanophycées épiphytes; peut-être les «filaments verts» (Ostreobium) existant dans le squelette des Coraux. L'apport énergétique d'origine planctonique paraît faible. 3. La plupart des Cnidaires sessiles, et particulièrement les Zoanthaires, produisent des quantités importantes de mucus; celui-ci intervient sans doute dans la genèse d'agrégats particulaires, pourvus d'une couverture de microorganismes épiphytes; cette production «paraprimaire» est récupérée par le complexe récifal, d'une part au niveau des bancs de sables grossiers, et, d'autre part, par le réseau alvéolaire évoqué ci-dessous. 4. La lacune la plus grave de toutes les études antérieures concernant le complexe biocoenotique récifal est de n'avoir considéré que ce qui existait sur le récif construit et d'avoir négligé la riche faune de petits invertébrés, appartenant essentiellement à l'échelon secondaire de la pyramide alimentaire, faune qui est enfermée dans un système de cavités («maille récifale”) d'où elle ne sort que sous l'effet de la surpopulation. 5. La production relativement faible des édifices récifaux à l'échelon des poissons carnivores paraît résulter essentiellement du blocage de cette production secondaire au sein de la «maille récifale»; il y a là un gigantesque gaspillage de production animale qui fait du complexe récifal un système déséquilibré sur le plant trophique.
    Notes: Abstract Seven years of investigations on the so-called “Grand Récif” at Tuléar (south-western coast of Madagascar) lead the authors to put forward several hypotheses about the trophic structure of this biocoenotic complex. The Tuléar coral reef seems to be an almost autarchic system, with a very important benthic primary production by xanthelles, epiphytic diatoms and blue-green algae, and perhaps “green filaments” (Ostreobium); the energetic contribution from planktonic production seems to be rather small. A very important content of organic aggregates in the reef waters probably results from the high production of mucus by most of the corals and similar organisms (mainly zoantharians). This “paraprimary” production is trapped in the coarse sand banks and in the “mesh” of the reef (see below). The fauna of small invertebrates, belonging mainly to the secondary link of the food chain, is very rich in the small holes and crevices existing in the reef mass, but scarce in the biocoenoses on the reef surface. The dead parts of the reef have a “mesh” structure which confines most of this fauna representing the secondary level of the food pyramid. The production of fish in the reef coral environment is poor, probably because of the blocking of most of this secondary production in the reef's “mesh” structure; in this alveolary system a gigantic wasting of animal production takes place, which makes the trophic structure of the coral reef complex and quite unbalanced.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1619-7089
    Keywords: Ventilated anaesthetised baboon model ; Technetium-99m hexamethylpropylene amine oxime single-photon emission tomography ; Drug-induced cerebral blood flow changes ; Lidocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The baboon under general anaesthesia as a model to assess drug-induced cerebral blood flow changes (Δ CBF) using single-photon emission tomography (SPET) offers great in vivo possibilities but has to comply with demands on control of anaesthesia-related influencing factors, such as P aCO2 changes. The model sought in this study and described here allows control of P aCO2, in the baboon under thiopentone anaesthesia by ventilation, and was evaluated for the functional dependence of Δ CBF vs Δ P aCO2, using SPET technetium-99m hexamethylpropylene amine oxime (HMPAO) and the split-dose method together with controlled ventilation. During the experiment the model was validated for normal reactivity to P aCO2 changes, and subsequently applied to investigate the mechanisms (still uncertain) of CBF increase known to follow administration of the local anaesthetic lidocaine. Six baboons received 6 mg/kg lidocaine intravenously. CBF was measured between two consecutive SPET acquisitions (split-dose method) respectively relating to HM-PAO distributions in the brain before and after the injection of lidocaine. Meanwhile the animals were maintained at constant respiratory rate and volume. The results indicate that the correlation between Δ CBF and the ensuing fall in PaCO2 deviated from the baseline pattern from the model and confirmed a cerebrovascular contribution to the lidocaine-induced CBF increase. This agreed well with mean and systolic blood pressure changes and heart rate.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Plant foods for human nutrition 13 (1966), S. 274-279 
    ISSN: 1573-9104
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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