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  • 2005-2009  (4)
  • 1985-1989  (10)
  • 1940-1944  (3)
  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amyloid β-peptide (Aβ)1−42 oligomers have recently been discussed as intermediate toxic species in Alzheimer's disease (AD) pathology. Here we describe a new and highly stable Aβ1−42 oligomer species which can easily be prepared in vitro and is present in the brains of patients with AD and Aβ1−42-overproducing transgenic mice. Physicochemical characterization reveals a pure, highly water-soluble globular 60-kDa oligomer which we named ‘Aβ1−42 globulomer’. Our data indicate that Aβ1−42 globulomer is a persistent structural entity formed independently of the fibrillar aggregation pathway. It is a potent antigen in mice and rabbits eliciting generation of Aβ1−42 globulomer-specific antibodies that do not cross-react with amyloid precursor protein, Aβ1−40 and Aβ1−42 monomers and Aβ fibrils. Aβ1−42 globulomer binds specifically to dendritic processes of neurons but not glia in hippocampal cell cultures and completely blocks long-term potentiation in rat hippocampal slices. Our data suggest that Aβ1−42 globulomer represents a basic pathogenic structural principle also present to a minor extent in previously described oligomer preparations and that its formation is an early pathological event in AD. Selective neutralization of the Aβ globulomer structure epitope is expected to have a high potential for treatment of AD.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Journal of quantitative analysis in sports 2 (2006), S. 4 
    ISSN: 1559-0410
    Source: Berkeley Electronic Press Academic Journals
    Topics: Sports Science
    Notes: We provide a response to Beech's review of The Wages of Wins: Taking Measure of the Many Myths in Modern Sport in this journal. Specifically we are responding to three misinterpretations and/or misstatements in the book review. At the end of each section we explain the process in which we reach our conclusions and where we differ with the reviewer's ascertations.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    The @journal of analytical psychology 50 (2005), S. 0 
    ISSN: 1468-5922
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: Abstract:  This paper looks at some of the processes that are at work in finding oneself in analysis. It explores Jung's unique contribution to our thinking about the self and its dynamic of individuation. The author attempts to show how the Self, in its quest for consciousness, requires the surrendering of ego inflation—the narcissistic delusion that the ego is the self. A case is made for seeing analysis as an individuation process which offers the opportunity for experiences of a more authentic sense of oneself. Jung stated that individuation requires the ego to enter into service of the Self. For this to happen, the author argues that both patient and analyst must be prepared to make sacrifices and take risks. Using clinical examples, he illustrates that, although purposive, the Self can be experienced as violent and destructive if the ego is unable to facilitate its expression. This may result in an individuation crisis for both analyst and patient. The paper demonstrates how impasse in analysis can evoke the transcendent function, which also requires sacrifices to be made and risks to be taken for analysis to proceed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Protein phosphorylation is estimated to affect 30% of the proteome and is a major regulatory mechanism that controls many basic cellular processes. Until recently, our biochemical understanding of protein phosphorylation on a global scale has been extremely limited; only one half of the yeast ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 326 (1987), S. 512-515 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Genetic studies of promoters activated by El A have failed to locate a sequence element whose function is to mediate El A transactivation5"8. Genetic and biochemical studies suggest that El A, rather than being a transcription factor itself, up-regulates the activity of host-cell transcription ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 14 (1942), S. 112-117 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 14 (1942), S. 1-19 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Zusammenfassung Der strenge Winter 1939/40 bot die Möglichkeit, ein großes Material von älteren, zum Teil im Ertragsalter stehenden Kern- und Steinobstsämlingen auf sein Verhalten gegenüber der Frosteinwirkung im Vergleich mit dem Grad der Frostempfindlichkeit der Elternformen zu prüfen. Untersucht wurden beim Apfel Nachkommen von Kultursorten (frei abg. und Kreuzungen zwischen Sorten), von Malus-Arten und Bastardformen (frei abg. und Kreuzungen zwischen Malus-Arten), Nachkommen aus Kreuzungen zwischen Kultursorten und Malus-Arten, aus Kreuzungen der Sorten-Spezies-Bastarde mit Kultursorten, bei der Birne Nachkommen von Kultursorten (frei abg. und Kreuzungen zwischen Sorten) und von Pirus-Arten (frei abg.), von Kirschen Nachkommen aus Kreuzungen zwischen Süßkirschensorten, aus Kreuzungen zwischen Sauerkirschensorten bzw. Amarellen und aus Kreuzungen zwischen Süß-und Sauerkirschen, von Pflaumen Sämlinge von Kultursorten (frei abg. und Kreuzungen zwischen Sorten). Das umfangreichste und aufschlußreichste Material stellten die Apfelsämlinge dar. Das Verhalten der Nachkommenschaften führte zu der Feststellung, daß 1. der für die Ausgangsformen festgestellte Grad der Frostempfindlichkeit eine genotypisch bedingte Eigenschaft ist und 2. daß viele Apfelsorten die für sie typische Reaktion gegen Frost in starkem Maße auf ihre Nachkommen übertragen. Die züchterische Bedeutung dieser Feststellungen liegt darin, daß 1. ein gutes Bild über den Zuchtwert bestimmter Sorten hinsichtlich der Frostresistenz gewonnen wurde und 2. die Ergebnisse der Beobachtungen dazu ermutigen, beim Apfel in der Züchtung auf Frostresistenz auf den schwierigen Weg über die Artbastardierung ganz zu verzichten. Die Annahme einer genotypischen Bedingtheit der sorteneigentümlichen Reaktion gegen-über Frosteinwirkungen wird auch auf die anderen Fruchtgattungen übertragen. Bei der Birne sind die Aussichten für die Auslese frostresistenter Formen aus Nachkommenschaften von Kultursorten bei weitem ungünstiger als beim Apfel. Unter den Kirschen- und Pflaumensämlingen wurden Formen ausgelesen, die genügende Frostresistenz mit ansprechender Fruchtqualität in sich vereinigen.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 12 (1940), S. 281-289 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Advanced Materials 1 (1989), S. 51-53 
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 97 (1985), S. 418-419 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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